whipples-disease
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Whipples Disease

Whipples Disease

Last Reviewed : 12/29/2020
Whipples Disease

Whipple's disease is a rare, systemic infectious disease caused by the bacterium Tropheryma whipplei. First described by George Hoyt Whipple in 1907 and commonly considered a gastrointestinal disorder, Whipple's disease primarily causes malabsorption but may affect any part of the body including the heart, brain, joints, skin, lungs and the eyes. Weight loss, diarrhea, joint pain, and arthritis are common presenting symptoms, but the presentation can be highly variable and approximately 15% of patients do not have these classic signs and symptoms. Whipple's disease is significantly more common in men, with 87% of the patients being male. When recognized and treated, Whipple's disease can usually be cured with long-term antibiotic therapy; if the disease is left untreated, it is ultimately fatal.

We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.

 

Basic information:

http://www.mayoclinic.org/diseases-conditions/whip... mayoclinic whipple's disease

https://www.niddk.nih.gov/health-information/healt... national institute of diabetes and digestive and kidney diseases. whipple's disease

https://medlineplus.gov/ency/article/000209.htm medline plus whipple's disease

http://www.healthline.com/health/whipples-disease health line whipple's disease

http://www.merckmanuals.com/professional/gastroint... merck manuals(professional version) whipple's disease

http://www.nytimes.com/health/guides/disease/whipp... new york times whipple's disease

http://www.everydayhealth.com/whipples-disease/gui... every day health what is whipple’s disease?

http://umm.edu/health/medical/ency/articles/whippl... university of maryland medical center whipple's disease

http://my.clevelandclinic.org/health/diseases_cond... cleveland clinic whipple's disease

 

Advanced information:

http://emedicine.medscape.com/article/183350-overv... medscape whipple disease

http://patient.info/in/doctor/whipples-disease patient whipple's disease

http://www.medicalnewstoday.com/articles/188228.ph... medical news today what is whipple's disease? what causes whipple's disease?

http://rarediseases.org/rare-diseases/whipple-dise... national organisation for rare diseases whipple's disease

http://www.dermnetnz.org/systemic/whipple.html dermnet nz whipple's disease

http://www.whipplesdisease.net/diagnosis/histopath... histology of intestinal whipple´s disease revisited. a study of 48 patients

http://www.rightdiagnosis.com/w/whipples_disease/i... right diagnosis whipple's disease

http://www.dovemed.com/diseases-conditions/whipple... dove med whipple’s disease lymphadenopathy

http://www.histopathology-india.net/whipple.htm histopathology.net pathology of whipple's disease

http://www.pathologyoutlines.com/topic/smallbowelw... pathology outlines small bowel (small intestine) infectious disorders:whipple disease

http://www.antimicrobe.org/m07.asp antimicrobe tropheryma whippelii (whipple's disease)

http://www.uveitis.org/docs/dm/opthalmic_whipples_... ophthalmic whipple's disease

http://radiopaedia.org/articles/whipple-disease radiopedia whipple's disease

 

Research:

http://bmcendocrdisord.biomedcentral.com/articles/... reversible hypothyroidism and whipple's disease by huy a tran et al., bmc endocrine disorders20066:3 doi: 10.1186/1472-6823-6-3

http://europepmc.org/backend/ptpmcrender.fcgi?acci... al moussawi k, ghigo e, kalinke u, alexopoulou l, mege j-l, et al. (2010) type i interferon induction is detrimental during infection with the whipple’s disease bacterium, tropheryma whipplei. plos pathog 6(1): e1000722. doi:10.1371/journal.ppat.1000722

http://europepmc.org/backend/ptpmcrender.fcgi?acci... : mottola g, boucherit n, trouplin v, oury barry a, soubeyran p, et al. (2014) tropheryma whipplei, the agent of whipple’s disease, affects the early to late phagosome transition and survives in a rab5- and rab7-positive compartment. plos one 9(2): e89367. doi:10.1371/journal.pone.0089367

http://www.scielo.br/scielo.php?script=sci_arttext... rev. inst. med. trop. s. paulo vol.43 no.1 são paulo jan./feb. 2001 http://dx.doi.org/10.1590/s0036-46652001000100009 whipple's disease. report of five cases with different clinical features by maria de lourdes de abreu ferrari

http://www.scielo.br/scielo.php?script=sci_arttext... arq. bras. cardiol. vol.80 no.3 são paulo mar. 2003 http://dx.doi.org/10.1590/s0066-782x2003000300009 case report:symptomatic myocardial bridging or cardiacwhipple's diseas by virgínia l. ribeiro cabral et al.,

http://www.scielo.br/scielo.php?script=sci_arttext... rev. inst. med. trop. s. paulo vol.54 no.5 são paulo sept./oct. 2012 http://dx.doi.org/10.1590/s0036-46652012000500010 case report:whipple's disease: rare disorder and late diagnosis by viviane plasse renon et al.,

http://europepmc.org/backend/ptpmcrender.fcgi?acci... benoit m, fenollar f, raoult d, mege j-l (2007) increased levels of circulating il-16 and apoptosis markers are related to the activity of whipple’s disease. plos one 2(6): e494. doi:10.1371/journal.pone.0000494

http://www.scielo.br/scielo.php?script=sci_arttext... braz j infect dis vol.18 no.3 salvador may/june 2014 http://dx.doi.org/10.1016/j.bjid.2014.01.006 case reports : tumoural form of whipple's disease simulating carcinomatosis by jamille hemétrio salles martins costa et al.,

http://www.scielo.br/scielo.php?script=sci_arttext... arq. neuro-psiquiatr. vol.62 no.2a são paulo june 2004 http://dx.doi.org/10.1590/s0004-282x2004000200028 whipple's disease with neurological manifestions: case report by marcondes c. frança jr et al.,

http://jmedicalcasereports.biomedcentral.com/artic... neurological presentation of whipple's disease after long-term antibiotic treatment: a case report by felix gundling et al., journal of medical case reports20082:191 doi: 10.1186/1752-1947-2-191

http://cmr.asm.org/content/14/3/561.full whipple's disease and “tropheryma whippelii” by fabrizio dutly* and martin altwegg doi: 10.1128/cmr.14.3.561-583.2001clin. microbiol. rev. july 2001vol. 14 no. 3 561-583

http://cid.oxfordjournals.org/content/32/3/457.ful... whipple's disease and tropheryma whippelii: secrets slowly revealed by larry j. strausbaugh et al., clin infect dis. (2001) 32 (3):457-463.doi: 10.1086/318512

http://www.hindawi.com/journals/grp/2013/478349/ jan bureš, marcela kopácová, tomáš douda, et al., “whipple’s disease: our own experience and review of the literature,” gastroenterology research and practice, vol. 2013, article id 478349, 10 pages, 2013. doi:10.1155/2013/478349

 

Related topics:

https://www.organicfacts.net/home-remedies/whipple... organic facts home remedies of whipple’s disease

 

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