Whipple's disease is a rare, systemic infectious disease caused by the bacterium Tropheryma whipplei. First described by George Hoyt Whipple in 1907 and commonly considered a gastrointestinal disorder, Whipple's disease primarily causes malabsorption but may affect any part of the body including the heart, brain, joints, skin, lungs and the eyes. Weight loss, diarrhea, joint pain, and arthritis are common presenting symptoms, but the presentation can be highly variable and approximately 15% of patients do not have these classic signs and symptoms. Whipple's disease is significantly more common in men, with 87% of the patients being male. When recognized and treated, Whipple's disease can usually be cured with long-term antibiotic therapy; if the disease is left untreated, it is ultimately fatal.
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http://europepmc.org/backend/ptpmcrender.fcgi?acci... al moussawi k, ghigo e, kalinke u, alexopoulou l, mege j-l, et al. (2010) type i interferon induction is detrimental during infection with the whipple’s disease bacterium, tropheryma whipplei. plos pathog 6(1): e1000722. doi:10.1371/journal.ppat.1000722
http://europepmc.org/backend/ptpmcrender.fcgi?acci... : mottola g, boucherit n, trouplin v, oury barry a, soubeyran p, et al. (2014) tropheryma whipplei, the agent of whipple’s disease, affects the early to late phagosome transition and survives in a rab5- and rab7-positive compartment. plos one 9(2): e89367. doi:10.1371/journal.pone.0089367
http://europepmc.org/backend/ptpmcrender.fcgi?acci... benoit m, fenollar f, raoult d, mege j-l (2007) increased levels of circulating il-16 and apoptosis markers are related to the activity of whipple’s disease. plos one 2(6): e494. doi:10.1371/journal.pone.0000494
http://cmr.asm.org/content/14/3/561.full whipple's disease and “tropheryma whippelii” by fabrizio dutly* and martin altwegg doi: 10.1128/cmr.14.3.561-583.2001clin. microbiol. rev. july 2001vol. 14 no. 3 561-583
http://www.hindawi.com/journals/grp/2013/478349/ jan bureš, marcela kopácová, tomáš douda, et al., “whipple’s disease: our own experience and review of the literature,” gastroenterology research and practice, vol. 2013, article id 478349, 10 pages, 2013. doi:10.1155/2013/478349