Sub acute combined degeneration of spinal cord

Sub acute combined degeneration of spinal cord

Last Reviewed : 12/25/2020

Subacute combined degeneration of spinal cord, also known as Lichtheim's disease, refers to degeneration of the posterior and lateral columns of the spinal cord as a result of vitamin B12 deficiency (most common), vitamin E deficiency, and copper deficiency. It is usually associated with pernicious anemia.

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Basic information: medline plus subacute combined degeneration,-spinal-cord,-and-nerve-disorders/spinal-cord-disorders/subacute-combined-degeneration msd manuals subacute combined degeneration new york times subacute combined degeneration symptoma subacute combined degeneration very well myeloneuropathy symptoms from vitamin b12 deficiency


Advanced information: medscape vitamin b-12 associated neurological diseases radiopedia subacute combined degeneration of the cord pathology outlines subacute combined degeneration right diagnosis subacute combined degeneration


Research: j neurol neurosurg psychiatry 1998;65:822-827 doi:10.1136/jnnp.65.6.822 paper :subacute combined degeneration: clinical, electrophysiological, and magnetic resonance imaging findings by b hemmer,f x glocker,m schumacher,g deuschl,c h lücking azize esra gürsoy, mehmet kolukisa, gülsen babacan-yildiz, and arif çelebi, “subacute combined degeneration of the spinal cord due to different etiologies and improvement of mri findings,” case reports in neurological medicine, vol. 2013, article id 159649, 5 pages, 2013. doi:10.1155/2013/159649 vasconcelos om, poehm eh, mccarter rj, campbell ww, quezado zmn. potential outcome factors in subacute combined degeneration: review of observational studies. journal of general internal medicine. 2006;21(10):1063-1068. doi:10.1111/j.1525-1497.2006.00525.x. european journal of neurology
volume 9 issue 1 page 101 - january 2002 doi:10.1046/j.1468-1331.2002.00336.x mr findings in subacute combined degeneration of the spinal cord caused by nitrous oxide anaesthesia - two cases by s. ilniczky et al., marshall r, milburn jm. clinical images - a quarterly column: subacute combined degeneration of the spinal cord. the ochsner journal. 2013;13(2):183-185.

pendse n a, bafna p. subacute combined degeneration of cord (scd ) - case report and review of literature. indian j radiol imaging [serial online] 2003 [cited 2017 jan 26];13:431-2. available from:

srikanth s g, jayakumar p n, vasudev m k, taly a b, chandrashekar h s. mri in subacute combined degeneration of spinal cord : a case report and review of literature. neurol india [serial online] 2002 [cited 2017 jan 26];50:310. available from: subacute combined degeneration of the spinal cord in pernicious anemiaresults of treatment in seventy-four consecutive cases with certain clinical observations by h. h. hyland, m.b. (tor.), f.r.c.p.(c.); r. f. farquharson, m.b. (tor.), f.r.c.p.(c.) arch neurpsych. 1936;36(6):1166-1205. doi:10.1001/archneurpsyc.1936.02260120013002 sao paulo med. j. vol.130 no.4 são paulo 2012 case report:subacute combined spinal cord degeneration and pancytopenia secondary to severe vitamin b12 deficiency by josé luis cabrerizo-garcía et al., rehabilitation essential in the recovery of multifactorial subacute combined degeneration by joseph chin et al., ann phys rehabil med. 2015 june; 58(3): 190–192.


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