sjogren-syndromekeratonconjuntivitis-siccasicca-syndrome
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Sjogren syndrome;Keratonconjuntivitis sicca;Sicca syndrome

Sjogren syndrome;Keratonconjuntivitis sicca;Sicca syndrome

Last Reviewed : 12/25/2020
Sjogren syndrome;Keratonconjuntivitis sicca;Sicca syndrome

Sjogren's syndrome (SjS, SS) is a long term autoimmune disease in which the moisture-producing glands of the body are affected. This results primarily in the development of a dry mouth and dry eyes. Other symptoms can include dry skin, a chronic cough, vaginal dryness, numbness in the arms and legs, feeling tired, muscle and joint pains, and thyroid problems. Those affected are at an increased risk (5%) of lymphoma.

While the exact cause is unclear it is believed to involve a combination of genetics and an environmental trigger such as exposure to a virus or bacteria. It can occur independently of other health problems (primary Sjögren's syndrome) or as a result of anotherconnective tissue disorder (secondary Sjögren's syndrome). The inflammation that results progressively damages the glands. Diagnosis is by biopsy of moisture producing glands and blood tests looking for specific antibodies. On biopsy there is typicallylymphocyte within the glands.

Treatment is directed at the person's symptom. For dry eyes artificial tears, medications to reduce inflammation, or surgery to shut the tear ducts may be tried. For a dry mouth chewing gum, sipping water, or a saliva substitute may be used. In those with joint or muscle pain ibuprofen may be used. Medications that can cause dryness may also be stopped such as antihistamines.

The disease was described in 1933 by Henrik Sjögren after whom it is named; however, a number of earlier description of people with the symptoms exist. Between 0.2% and 1.2% of the population are affected, with half having the primary form and half the secondary form. Females are affected about ten times as often as males and it commonly begins in middle age. Anyone; however, can be affected. Among those without other autoimmune disorders, life expectancy is unchanged.

We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.

 

Basic information:

http://www.mayoclinic.org/diseases-conditions/sjogrens-syndrome/basics/definition/con-20020275 mayoclinic sjogren's syndrome

http://www.nhs.uk/conditions/sjogrens-syndrome/pages/introduction.aspx nhs uk sjogren's syndrome

http://www.niams.nih.gov/health_info/sjogrens_syndrome/sjogrens_syndrome_ff.asp national institute of arthritis and musculoskeletal and skin diseases sjogren's syndrome

http://www.webmd.com/a-to-z-guides/sjogrens-syndrome#1 web md sjogren's syndrome

http://www.webmd.com/rheumatoid-arthritis/arthritis-sjogrens-syndrome web md arthritis and sjögren's syndrome

https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/sjogrens-syndrome better health sjogren’s syndrome

http://www.healthline.com/health/sjogren-syndrome health line sjogren's syndrome

http://www.arthritis.org/about-arthritis/types/sjogrens-syndrome/causes.php arthritis foundation sjögren’s syndrome causes

http://my.clevelandclinic.org/services/orthopaedics-rheumatology/diseases-conditions/hic-sjogrens-syndrome cleveland clinic sjogren's syndrome

https://medlineplus.gov/ency/article/000456.htm medline plus sjogren's syndrome

http://www.everydayhealth.com/sjogrens-syndrome/guide/ everyday health sjogren's syndrome

https://labtestsonline.org/understanding/conditions/sjogren/ lab tests online sjogren's syndrome

https://www.cedars-sinai.edu/patients/health-conditions/sjogrens-syndrome.aspx cedar sinai sjogren's syndrome

http://www.healthcentral.com/encyclopedia/hc/sjogrens-syndrome-3168491/ health central sjogren's syndrome

http://www.hse.ie/eng/health/az/s/sjogren's-syndrome/ health service executive sjogren's syndrome

http://umm.edu/health/medical/ency/articles/sjogren-syndrome university of maryland medical center sjogren's syndrome

 

Advanced information:

http://www.medicinenet.com/sjogrens_syndrome/article.htm medicine net sjogren's syndrome

http://emedicine.medscape.com/article/332125-overview medscape sjogren syndrome

http://www.medicalnewstoday.com/articles/233747.php medical news today what is sjogren's syndrome? what causes sjogren's syndrome?

http://patient.info/in/doctor/sjogrens-syndrome-pro patient sjögren's syndrome

http://www.emedicinehealth.com/sjogren_syndrome/article_em.htm emedicine health sjogren's syndrome

http://radiopaedia.org/articles/sjogren-syndrome-1 radiopedia sjogren's syndrome

http://www.dermnetnz.org/immune/sjogren.html dermnet nz sjogren's syndrome

http://www.fpnotebook.com/rheum/diffuse/sjgrnssyndrm.htm family practise note book sjogren's syndrome

http://www.uptodate.com/contents/sjogrens-syndrome-beyond-the-basics upto date sjögren's syndrome overview

http://www.aafp.org/afp/2009/0315/p465.html diagnosis and management of sjögren syndrome by paul kruszka, lcdr, usphs, u.s. coast guard yard, baltimore, maryland.,robert j. o’brian, lcdr, mc, usn, national naval medical center, bethesda, maryland am fam physician. 2009 mar 15;79(6):465-470

http://www.physio-pedia.com/sjogren's_syndrome physio pedia sjogren's syndrome

http://www.irishhealth.com/article.html?con=623 irish health sjogren's syndrome-often underdiagnosed

http://www.newhealthadvisor.com/sjogren's-syndrome-diet.html news health advisor sjogren's syndrome diet

http://www.diagnose-me.com/symptoms-of/sjogrens-syndrome.php diagnose me sjogren's syndrome: overview

 

Research:

basavaraj a, badave rr, kadam m, kadam db. hypokalemic paralysis as a primary presentation of fanconi's syndrome and distal renal tubular acidosis in a patient with primary sjogren's syndrome. neurol india [serial online] 2015 [cited 2016 jul 24];63:446-8. available from: http://www.neurologyindia.com/text.asp?2015/63/3/446/158264

haroon n, nisha r s, chandran v, bharadwaj a. pulmonary hypertension not a major feature of early mixed connective tissue disease: a prospective clinicoserological study. j postgrad med [serial online] 2005 [cited 2016 jul 24];51:104-8. available from: http://www.jpgmonline.com/text.asp?2005/51/2/104/16371

uppal m, srinivas c r, thowfeeq k t. sjogren-larsson syndrome: report of two cases. indian j dermatol venereol leprol [serial online] 2004 [cited 2016 jul 24];70:110-1. available from: http://www.ijdvl.com/text.asp?2004/70/2/110/6905

http://europepmc.org/backend/ptpmcrender.fcgi?accid=pmc4596882&blobtype=pdf chen c-h, chen h-c, chang c-c, peng yj,lee c-h, shieh y-s, et al. (2015) growth arrestspecific 6 protein in patients with sjögren syndrome:determination of the plasma level and expression in the labial salivary gland. plos one 10(10):e0139955. doi:10.1371/journal.pone.0139955

kumar sp. a rare initial neurological presentation of sjogren's syndrome. j neurosci rural pract [serial online] 2015 [cited 2016 jul 24];6:127. available from: http://www.ruralneuropractice.com/text.asp?2015/6/1/127/143226

http://europepmc.org/backend/ptpmcrender.fcgi?accid=pmc4309563&blobtype=pdf deng c, hu c, chen s, li j, wen x, wu z,et al. (2015) meta-analysis of anti-muscarinic receptor type 3 antibodies for the diagnosis of sjögren syndrome. plos one 10(1): e0116744. doi:10.1371/ journal.pone.0116744

http://journal.frontiersin.org/article/10.3389/fonc.2015.00179/full clinical case study article front. oncol., 06 august 2015 | http://dx.doi.org/10.3389/fonc.2015.00179 sjögren syndrome complicated by mucosa-associated lymphoid tissue lymphoma and lymphocytic interstitial pneumonia by fatma ahmed et al.,

khanna d, shrivastava a. suppurative dacroadenitis causing ocular sicca syndrome in classic wegener's granulomatosis. indian j ophthalmol [serial online] 2011 [cited 2016 jul 24];59:151-3. available from: http://www.ijo.in/text.asp?2011/59/2/151/77044

el ati z, fatma lb, boulahya g, rais l, krid m, smaoui w, maiz hb, beji s, zouaghi k, moussa fb. osteomalacia complicating renal tubular acidosis in association with sjogren's syndrome. saudi j kidney dis transpl [serial online] 2014 [cited 2016 jul 24];25:1072-7. available from: http://www.sjkdt.org/text.asp?2014/25/5/1072/139944

yadav r, krishnan p, kulkarni gb, yasha t c, kumar m v, nagraja d. spectrum of neuro-sjogren's syndrome in a tertiary care center in south india. ann indian acad neurol [serial online] 2011 [cited 2016 jul 24];14:111-5. available from: http://www.annalsofian.org/text.asp?2011/14/2/111/82797

dhanuka a k, gupta m. sjogren - larsson syndrome : a case report. neurol india [serial online] 2002 [cited 2016 jul 24];50:371. available from: http://www.neurologyindia.com/text.asp?2002/50/3/371/1419

tiwari s c, dhingra k, khan k m, malviya a n, singh m, gehlot d k. sjogren's syndrome in association with retinitis pigmentosa-report of an unusual case. indian j ophthalmol [serial online] 1983 [cited 2016 jul 24];31:81-3. available from: http://www.ijo.in/text.asp?1983/31/2/81/27445

http://europepmc.org/backend/ptpmcrender.fcgi?accid=pmc3896357&blobtype=pdf morreale m, marchione p, giacomini p, pontecorvo s, marianetti m, et al. (2014) neurological involvement in primary sjo¨gren syndrome: a focus on central nervous system. plos one 9(1): e84605. doi:10.1371/journal.pone.0084605

ghorbel i b, feki n b, salem t b, hamzaoui a, khanfir m, lamloum m, miled m, houman m h. microscopic polyangiitis associated with primary biliary cirrhosis, sjogren's syndrome and hashimoto's thyroiditis. saudi j kidney dis transpl [serial online] 2015 [cited 2016 jul 24];26:359-62. available from: http://www.sjkdt.org/text.asp?2015/26/2/359/152515

 

Related topics:

http://treatment.hpathy.com/homeo-medicine/homeopathy-sjogrens-syndrome/ hpathy homeopathy for sjogren’s syndrome

 

Other articles:

http://www.petmd.com/dog/conditions/eyes/c_dg_sjogren_like_syndrome pet md sjögren-like syndrome in dogs

 

Other helpful resources(support groups):

http://www.sjogrensindia.org/ sjogrens india

https://www.bssa.uk.net/ the british sjogren syndrome association

http://www.sjogrensnewzealand.co.nz/resources/sjogren-articles/what-sjogrens-syndrome/ sjogren syndrome society

http://www.sjogrens.org.au/ the australian sjogren syndrome association

 

Related videos:

https://www.youtube.com/watch?v=_kwf_lcwh2m sjogren's syndrome

https://www.youtube.com/watch?v=lfw2oybbkg0 10 major symptoms of sjogren's syndrome

https://www.youtube.com/watch?v=mf8smepemsm sjogren's syndrome information | dr. mitchel goldman

https://www.youtube.com/watch?v=4valn__aq7c sjögren's syndrome

https://www.youtube.com/watch?v=6snwsqth_oa update on sjogren's syndrome: from pathogeny to treatment - xavier mariette, m.d., ph.d.

 

Presentations/quiz/newspaper articles:

http://healthland.time.com/2011/09/01/what-is-sjogrens-syndrome-an-expert-explains-venus-williams-diagnosis/health land what is sjögren’s syndrome? an expert explains venus williams’ diagnosis

http://www.thebetterindia.com/12659/sjogrens-syndrome-support-group-india/ better india heard of sjögren’s syndrome? these women are ‘living well’ with it and helping others do the same!

http://www.dailymail.co.uk/news/article-2079539/sjogrens-syndrome-venus-williams-opens-incurable-disease.html daily mail 'i won't let it beat me:' venus williams opens up about being diagnosed with incurable sjogren's syndrome at 31

read more: http://www.dailymail.co.uk/news/article-2079539/sjogrens-syndrome-venus-williams-opens-incurable-disease.html#ixzz4g3loy39d

http://www.newindianexpress.com/states/tamil_nadu/sjogren%e2%80%99s-syndrome-not-a-rarity-among-indians-finds-study/2014/12/06/article2558152.ece new indian express sjogren’s syndrome not a rarity among indians, finds study

http://www.eurekalert.org/pub_releases/2015-02/oup-fwp020315.php eurekalert females with primary sjogren's syndrome more likely to experience sexual dysfunction

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