Retinitis pigmentosa (RP) is an inherited, degenerative eye disease that causes severe vision impairmentdue to the progressive degeneration of the rod photoreceptor cells in the retina. This form of retinal dystrophy manifests initial symptoms independent of age; thus, RP diagnosis occurs anywhere from early infancy to late adulthood. Patients in the early stages of RP first notice compromised peripheral and dim light vision due to the decline of the rod photoreceptors. The progressive rod degeneration is later followed by abnormalities in the adjacent retinal pigment epithelium (RPE) and the deterioration of cone photoreceptor cells. As peripheral vision becomes increasingly compromised, patients experience progressive "tunnel vision" and eventual blindness. Affected individuals may additionally experience defective light-dark adaptations, nyctalopia (night blindness), and the accumulation of bone spicules in the fundus.
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http://www.hindawi.com/journals/joph/2015/737053/ marta sacchetti, flavio mantelli, daniela merlo, and alessandro lambiase, “systematic review of randomized clinical trials on safety and efficacy of pharmacological and nonpharmacological treatments for retinitis pigmentosa,” journal of ophthalmology, vol. 2015, article id 737053, 11 pages, 2015. doi:10.1155/2015/737053