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Retinitis Pigmentosa(RP)

Retinitis Pigmentosa(RP)

Last Reviewed : 12/25/2020

Retinitis pigmentosa (RP) is an inherited, degenerative eye disease that causes severe vision impairment due to the progressive degeneration of the rod photoreceptor cells in the retina. This form of retinal dystrophy manifests initial symptoms independent of age; thus, RP diagnosis occurs anywhere from early infancy to late adulthood. Patients in the early stages of RP first notice compromised peripheral and dim light vision due to the decline of the rod photoreceptors. The progressive rod degeneration is later followed by abnormalities in the adjacent retinal pigment epithelium (RPE) and the deterioration of cone photoreceptor cells. As peripheral vision becomes increasingly compromised, patients experience progressive "tunnel vision" and eventual blindness. Affected individuals may additionally experience defective light-dark adaptations, nyctalopia (night blindness), and the accumulation of bone spicules in the fundus.

We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.

 

Basic information:

http://www.aao.org/eye-health/diseases/what-is-retinitis-pigmentosa american cademy of ophthalmology what is retinitis pigmentosa?

https://nei.nih.gov/health/pigmentosa/pigmentosa_facts national eye institute facts about retinitis pigmentosa

http://www.allaboutvision.com/conditions/retinapigment.htm all about vision retinitis pigmentosa

http://www.visionaustralia.org/eye-health/eye-conditions/retinitis-pigmentosa vision australia retinitis pigmentosa

http://www.webmd.com/eye-health/retinitis-pigmentosa web md retinitis pigmentosa

https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/eyes-retinitis-pigmentosa better health retinitis pigmentosa

http://my.clevelandclinic.org/services/cole-eye/diseases-conditions/retinitis-pigmentosa cleveland clinic retinitis pigmentosa

http://www.aapos.org/terms/conditions/92 american association for pediatric ophthalmology and squint retinitis pigmentosa

http://www.aoa.org/patients-and-public/eye-and-vision-problems/glossary-of-eye-and-vision-conditions/retinitis-pigmentosa?sso=y american optometric association retinitis pigmentosa

http://www.merckmanuals.com/professional/eye-disorders/retinal-disorders/retinitis-pigmentosa merck manuals(professional version) retinitis pigmentosa

http://www.news-medical.net/health/what-is-retinitis-pigmentosa.aspx mews medical net what is retinitis pigmentosa?

http://www.nytimes.com/health/guides/disease/retinitis-pigmentosa/overview.html new york times retinitis pigmentosa

https://www.verywell.com/retinitis-pigmentosa-3421702 very well retinitis pigmentosa

http://umm.edu/health/medical/ency/articles/retinitis-pigmentosa university of maryland medical center retinitis pigmentosa

http://www.hopkinsmedicine.org/healthlibrary/conditions/eye_care/retinitis_pigmentosa_85,p00511/ john hopkins medicine retinitis pigmentosa

http://www.healthcentral.com/encyclopedia/hc/retinitis-pigmentosa-3169120/ health cntral retinitis pigmentosa

http://www.healthcommunities.com/retinitis-pigmentosa/retinitis-pigmentosa-overview.shtml health communities retinitis pigmentosa overview, risk factors, signs & symptoms

 

Advanced information:

http://emedicine.medscape.com/article/1227488-overview medscape retinitis pigmentosa

http://www.medicinenet.com/retinitis_pigmentosa/article.htm medicine net retinitis pigmentosa

https://www.genome.gov/13514348/learning-about-retinitis-pigmentosa/ national human genome research institute retinitis pigmentosa

http://patient.info/doctor/retinitis-pigmentosa patient retinitis pigmentosa

http://rarediseases.org/rare-diseases/retinitis-pigmentosa/ national organisation of rare diseases retinitis pigmentosa

http://kellogg.umich.edu/patientcare/downloads/understand-retinitis-pigmentosa.pdf understanding retinitis pigmentosa

university of pennsylvania. "study stops vision loss in late-stage canine x-linked retinitis pigmentosa." sciencedaily. sciencedaily, 12 october 2015. www.sciencedaily.com/releases/2015/10/151012174519.htm .

http://www.inlb.qc.ca/wp-content/uploads/2015/01/cuban-treatment-for-retinitis-pigmentosa.pdf is there evidence supporting the cuban treatment for retinitis pigmentosa ?

http://www.jkscience.org/archive/volume63/retini.pdf retinitis pigmentosa and allied disorders by yog raj sharma, p. raja rami reddy, deependra v. singh vol. 6 no. 3, july-september 2004

http://www.britannica.com/science/retinitis-pigmentosa britannica retinitis pigmentosa

 

Research:

http://www.hindawi.com/journals/joph/2015/737053/ marta sacchetti, flavio mantelli, daniela merlo, and alessandro lambiase, “systematic review of randomized clinical trials on safety and efficacy of pharmacological and nonpharmacological treatments for retinitis pigmentosa,” journal of ophthalmology, vol. 2015, article id 737053, 11 pages, 2015. doi:10.1155/2015/737053

http://www.sciencedirect.com/science/article/pii/s2001037015000276 using stem cells to model diseases of the outer retina by camille yvon et al., computational and structural biotechnology journal volume 13, 2015, pages 382–389 doi:10.1016/j.csbj.2015.05.001

http://epmajournal.biomedcentral.com/articles/10.1186/1878-5085-3-17 retinitis pigmentosa and ocular blood flow by katarzyna konieczka et al., epma journala journal of predictive, preventive and personalized medicine20123:17 doi: 10.1186/1878-5085-3-17

http://journal.frontiersin.org/article/10.3389/fncel.2015.00512/full mini review article:front. cell. neurosci., 12 january 2016 | http://dx.doi.org/10.3389/fncel.2015.00512 spontaneous oscillatory rhythms in the degenerating mouse retina modulate retinal ganglion cell responses to electrical stimulation by yong sook goo et al.,

http://www.mdpi.com/1422-0067/15/8/14456/htm int. j. mol. sci. 2014, 15(8), 14456-14474; doi:10.3390/ijms150814456 review:recent advances of stem cell therapy for retinitis pigmentosa by yuxi he et al.,

http://ojrd.biomedcentral.com/articles/10.1186/1750-1172-1-40 retinitis pigmentosa by christian hamel orphanet journal of rare diseases20061:40 doi: 10.1186/1750-1172-1-40

http://www.nature.com/articles/srep19969 precision medicine: genetic repair of retinitis pigmentosa in patient-derived stem cells by alexander g. bassuk, andrew zheng, yao li, stephen h. tsang & vinit b. mahajan scientific reports 6, article number: 19969 (2016) doi:10.1038/srep19969

http://hmg.oxfordjournals.org/content/11/10/1219.full retinitis pigmentosa and allied diseases: numerous diseases, genes, and inheritance patterns hum. mol. genet. (2002) 11 (10):1219-1227.doi: 10.1093/hmg/11.10.1219

http://www.sciencedirect.com/science/article/pii/s2211505612000233 retinal regeneration and stem cell therapy in retinitis pigmentosa by henry j. kaplan et al., taiwan journal of ophthalmology volume 2, issue 2, june 2012, pages 41–44 doi:10.1016/j.tjo.2012.03.003

http://archopht.jamanetwork.com/article.aspx?articleid=1157408 health services utilization and cost of retinitis pigmentosa by kevin d. frick, phd et al., arch ophthalmol. 2012;130(5):629-634. doi:10.1001/archophthalmol.2011.2820

https://www.jci.org/articles/view/82462 halting progressive neurodegeneration in advanced retinitis pigmentosa by susanne f. koch et al., j clin invest. 2015;125(9):3704-3713. doi:10.1172/jci82462.

 

Other articles:

http://www.guidedogs.com.au/education-and-resources/common-vision-impairments/retinitis-pigmentosa guide dogs retinitis pigmentosa

 

Other helpful resources(support groups):

http://www.blindness.org/retinitis-pigmentosa foundation fighting blindness

http://www.rnib.org.uk/eye-health/eye-conditions/retinitis-pigmentosa retinitis pigmentosa

http://www.rpfightingblindness.org.uk/home.php?home=yes rp fighting blindness

 

Related videos:

https://www.youtube.com/watch?v=w8vjf7kkjcq retinitis pigmentosa - scanning (daylight)

https://www.youtube.com/watch?v=tvd4cxgbxwe retinitis pigmentosa eye exercise to improve eyesight

https://www.youtube.com/watch?v=wnibkn6bnwq retinitis pigmentosa cure?

https://www.youtube.com/watch?v=oiqk8smdhbe retinitis pigmentosa treatment in india - vision can be restored

https://www.youtube.com/watch?v=eggmxifxseo retinitis pigmentosa - at night

https://www.youtube.com/watch?v=wykk_m909wk retinitis pigmentosa - blindness.

https://www.youtube.com/watch?v=y8ufubj4db0 retinitis pigmentosa: breakthrough result after 4 years

 

Presentations/quiz/newspaper articles:

http://www.techtimes.com/articles/123709/20160112/gene-editing-technique-crispr-may-treat-inherited-blindness-retinitis-pigmentosa.htm tech times gene editing technique crispr may treat inherited blindness retinitis pigmentosa

http://medicalxpress.com/news/2015-08-team-clinical-trial-stem-cell-based.html medical express team begins first clinical trial of stem cell-based retinitis pigmentosa treatment

http://www.abc.net.au/news/2015-03-05/perth-woman-to-fund-autoimmune-retinopathy-research/6284222 news perth woman with rare eye disorder retinitis pigmentosa to fund research into condition

http://www.huffingtonpost.com/entry/marijuana-blindness-prevent-study-retinitis-pigmentosis_n_4833183.html?section=india huffington post marijuana may prevent blindness in retinitis pigmentosa sufferers

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