Retinitis Pigmentosa(RP)

Retinitis Pigmentosa(RP)

Last Reviewed : 12/25/2020

Retinitis pigmentosa (RP) is an inherited, degenerative eye disease that causes severe vision impairment due to the progressive degeneration of the rod photoreceptor cells in the retina. This form of retinal dystrophy manifests initial symptoms independent of age; thus, RP diagnosis occurs anywhere from early infancy to late adulthood. Patients in the early stages of RP first notice compromised peripheral and dim light vision due to the decline of the rod photoreceptors. The progressive rod degeneration is later followed by abnormalities in the adjacent retinal pigment epithelium (RPE) and the deterioration of cone photoreceptor cells. As peripheral vision becomes increasingly compromised, patients experience progressive "tunnel vision" and eventual blindness. Affected individuals may additionally experience defective light-dark adaptations, nyctalopia (night blindness), and the accumulation of bone spicules in the fundus.

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Basic information: american cademy of ophthalmology what is retinitis pigmentosa? national eye institute facts about retinitis pigmentosa all about vision retinitis pigmentosa vision australia retinitis pigmentosa web md retinitis pigmentosa better health retinitis pigmentosa cleveland clinic retinitis pigmentosa american association for pediatric ophthalmology and squint retinitis pigmentosa american optometric association retinitis pigmentosa merck manuals(professional version) retinitis pigmentosa mews medical net what is retinitis pigmentosa? new york times retinitis pigmentosa very well retinitis pigmentosa university of maryland medical center retinitis pigmentosa,p00511/ john hopkins medicine retinitis pigmentosa health cntral retinitis pigmentosa health communities retinitis pigmentosa overview, risk factors, signs & symptoms


Advanced information: medscape retinitis pigmentosa medicine net retinitis pigmentosa national human genome research institute retinitis pigmentosa patient retinitis pigmentosa national organisation of rare diseases retinitis pigmentosa understanding retinitis pigmentosa

university of pennsylvania. "study stops vision loss in late-stage canine x-linked retinitis pigmentosa." sciencedaily. sciencedaily, 12 october 2015. . is there evidence supporting the cuban treatment for retinitis pigmentosa ? retinitis pigmentosa and allied disorders by yog raj sharma, p. raja rami reddy, deependra v. singh vol. 6 no. 3, july-september 2004 britannica retinitis pigmentosa


Research: marta sacchetti, flavio mantelli, daniela merlo, and alessandro lambiase, “systematic review of randomized clinical trials on safety and efficacy of pharmacological and nonpharmacological treatments for retinitis pigmentosa,” journal of ophthalmology, vol. 2015, article id 737053, 11 pages, 2015. doi:10.1155/2015/737053 using stem cells to model diseases of the outer retina by camille yvon et al., computational and structural biotechnology journal volume 13, 2015, pages 382–389 doi:10.1016/j.csbj.2015.05.001 retinitis pigmentosa and ocular blood flow by katarzyna konieczka et al., epma journala journal of predictive, preventive and personalized medicine20123:17 doi: 10.1186/1878-5085-3-17 mini review article:front. cell. neurosci., 12 january 2016 | spontaneous oscillatory rhythms in the degenerating mouse retina modulate retinal ganglion cell responses to electrical stimulation by yong sook goo et al., int. j. mol. sci. 2014, 15(8), 14456-14474; doi:10.3390/ijms150814456 review:recent advances of stem cell therapy for retinitis pigmentosa by yuxi he et al., retinitis pigmentosa by christian hamel orphanet journal of rare diseases20061:40 doi: 10.1186/1750-1172-1-40 precision medicine: genetic repair of retinitis pigmentosa in patient-derived stem cells by alexander g. bassuk, andrew zheng, yao li, stephen h. tsang & vinit b. mahajan scientific reports 6, article number: 19969 (2016) doi:10.1038/srep19969 retinitis pigmentosa and allied diseases: numerous diseases, genes, and inheritance patterns hum. mol. genet. (2002) 11 (10):1219-1227.doi: 10.1093/hmg/11.10.1219 retinal regeneration and stem cell therapy in retinitis pigmentosa by henry j. kaplan et al., taiwan journal of ophthalmology volume 2, issue 2, june 2012, pages 41–44 doi:10.1016/j.tjo.2012.03.003 health services utilization and cost of retinitis pigmentosa by kevin d. frick, phd et al., arch ophthalmol. 2012;130(5):629-634. doi:10.1001/archophthalmol.2011.2820 halting progressive neurodegeneration in advanced retinitis pigmentosa by susanne f. koch et al., j clin invest. 2015;125(9):3704-3713. doi:10.1172/jci82462.


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Other helpful resources(support groups): foundation fighting blindness retinitis pigmentosa rp fighting blindness


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Presentations/quiz/newspaper articles: tech times gene editing technique crispr may treat inherited blindness retinitis pigmentosa medical express team begins first clinical trial of stem cell-based retinitis pigmentosa treatment news perth woman with rare eye disorder retinitis pigmentosa to fund research into condition huffington post marijuana may prevent blindness in retinitis pigmentosa sufferers

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