Polycythemia (or Polycythaemia, see spelling differences) vera (PV, PCV) (also known as erythremia, primary polycythemia,Vaquez disease, Osler-Vaquez disease and polycythemia rubra vera) is a neoplasm in which the bone marrow makes too many red blood cells. It may also result in the overproduction of white blood cells and platelets.
Most of the health concerns associated with polycythemia vera are caused by the blood being thicker as a result of the increased red blood cells. It is more common in the elderly and may be symptomatic or asymptomatic. Common signs and symptoms include itching (pruritus), and severe burning pain in the hands or feet that is usually accompanied by a reddish or bluish coloration of the skin. Patients with polycythemia vera are more likely to have gouty arthritis. Treatment consists primarily of phlebotomy
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http://www.hindawi.com/journals/mi/2015/869242/ gregor hoermann, georg greiner, and peter valent, “cytokine regulation of microenvironmental cells in myeloproliferative neoplasms,” mediators of inflammation, vol. 2015, article id 869242, 17 pages, 2015. doi:10.1155/2015/869242
http://www.haematologica.org/content/99/6/945 optimal therapy for polycythemia vera and essential thrombocythemia can only be determined by the completion of randomized clinical trials by john mascarenhas, ruben mesa, josef prchal, ronald hoffman haematologica june 2014 99: 945-949; doi:10.3324/haematol.2014.106013