pertussiswhooping-cough100-day-cough
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Pertussis/Whooping cough/100 day cough

Pertussis/Whooping cough/100 day cough

Last Reviewed : 12/24/2020
Pertussis/Whooping cough/100 day cough

Pertussis (also known as whooping cough or 100-day cough) is a highly contagious bacterial disease. Initially, symptoms are usually similar to those of the common cold with a runny nose, fever, and mild cough. This is then followed by weeks of severe coughing fits. Following a fit of coughing, a high-pitched whoop sound or gasp may occur as the person breathes in. The coughing may last for 10 or more weeks, hence the phrase "100-day cough".A person may cough so hard that they vomit,break ribs, or become very tired from the effort. Children less than one year old may have little or no cough and instead haveperiods where they do not breathe. The time between infection and the onset of symptoms is usually seven to ten days. Disease may occur in those who have been vaccinated, but symptoms are typically milder.

Pertussis is caused by the bacterium Bordetella pertussis. It is an airborne disease which spreads easily through the coughs and sneezes of an infected person. People are infectious to others from the start of symptoms until about three weeks into the coughing fits. Those treated with antibiotics are no longer infectious after five days. Diagnosis is by collecting a sample from the back of the nose and throat. This sample can then be tested by either culture or by polymerase chain reaction.

Prevention is mainly by vaccination with the pertussis vaccine. Initial immunization is recommended between six and eight weeks of age, with four doses to be given in the first two years of life. The vaccine becomes less effective over time, with additional doses often recommended for older children and adults. Antibiotics may be used to prevent the disease in those who have been exposed and are at risk of severe disease. In those with the disease, antibiotics are useful if started within three weeks of the initial symptoms, but otherwise have little effect in most people. In children less than one year old and among those who are pregnant, they are recommended within six weeks of symptom onset. Antibiotics used include erythromycin,azithromycin, clarithromycin, or trimethoprim/sulfamethoxazole. Evidence to support the effectiveness of medications for the cough is poor. Many children less than a year of age require hospitalization.

An estimated 16 million people worldwide are infected per year. Most cases occur in the developing world, and people of all ages may be affected. In 2013, it resulted in 61,000 deaths – down from 138,000 deaths in 1990. Nearly 0.5% of infected children less than one year of age die. Outbreaks of the disease were first described in the 16th century. The bacterium that causes the infection was discovered in 1906. The pertussis vaccine became available in the 1940s

We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.

 

Basic information:

https://medlineplus.gov/ency/article/001561.htm medline plus pertussis

http://www.nfid.org/pertussis/ natinal foundation for infectious diseases pertussis

http://www.mayoclinic.org/diseases-conditions/whooping-cough/basics/definition/con-20023295 mayo clinic whooping cough

https://www2.health.vic.gov.au/public-health/infectious-diseases/disease-information-advice/pertussis-whooping-cough victoria health.vic whooping cough

http://www.webmd.com/children/tc/whooping-cough-pertussis-topic-overview web md whooping cough (pertussis) - topic overview

http://www.healthlinkbc.ca/healthfiles/hfile15c.stm health link bc whooping cough

http://www.merckmanuals.com/professional/infectious-diseases/gram-negative-bacilli/pertussis merck manuals(professional version) whooping cough

http://www.immunizebc.ca/diseases-vaccinations/pertussis immunize bc whooping cough

https://www.healthychildren.org/english/health-issues/conditions/chest-lungs/pages/whooping-cough.aspx healthy children whooping cough

https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/whooping-cough better health whooping cough

http://www.nhs.uk/conditions/whooping-cough/pages/introduction.aspx nhs uk whooping cough

http://www.livescience.com/54210-whooping-cough-old-vaccine.html live science old vaccine, new tricks: revive early pertussis shot, study says

http://www.hopkinsmedicine.org/healthlibrary/conditions/adult/pediatrics/pertussis_in_children_22,pertussisinchildren/ john hopkins medical library pertussis in children

 

Advanced information:

http://www.immunize.org/catg.d/p4212.pdf immunize pertussis (whooping cough): questions and answers information about the disease and vaccines

http://www.vaccines.gov/diseases/pertussis/ vaccines.gov pertussis (whooping cough) vaccine

http://emedicine.medscape.com/article/967268-overview medscape whooping cough

http://kidshealth.org/en/parents/whooping-cough.html kids health whooping cough

https://labtestsonline.org/understanding/analytes/pertussis/tab/test/ lab tests online pertussis tests

https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/541694/guidelines_for_the_public_health_management_of_pertussis_in_england.pdf guidelines for the public health management of pertussis in england produced by the pertussis guidelines group

http://textbookofbacteriology.net/pertussis.html todars online text book of bacteriology bordetella pertussis and whooping cough

http://www.medicinenet.com/pertussis/article.htm medicine net whooping cough (pertussis)

https://www.hse.ie/eng/health/immunisation/hcpinfo/guidelines/chapter15.pdf heaslth service executive pertussis

http://patient.info/doctor/whooping-cough-pro patient whooping cough

http://www.genome.jp/kegg-bin/show_pathway?mmu05133 genome pertussis - mus musculus (mouse)

http://www.healio.com/infectious-disease/pediatric-id/news/print/infectious-disease-news/%7b995c9cc3-e549-4d4b-9ff9-ca7a809388bb%7d/unknown-toxin-may-be-cause-of-pertussis-cough healio unknown toxin may be cause of pertussis cough

 

Research:

http://ijp.mums.ac.ir/pdf_4157_c33b14918a5a9ad5c4b230d3c5d66320.html immunization coverage in who regions: a review article by rahim vakili et al., int j pediatr (supplement.1), vol.3, n.2-1, serial no.15, march 2015

http://www.kjp.or.kr/upload/2010530504-20100644181244.pdf update on pertussis and pertussis immunization by jung yun hong, m.d., ph.d. et al., doi: 10.3345/kjp.2010.53.5.629 korean j pediatr 2010;54(5):629-633

http://www.scielo.br/scielo.php?script=sci_arttext&pid=s0102-311x2013000700003&lng=en&tlng=en cad. saúde pública vol.29 no.7 rio de janeiro july 2013 http://dx.doi.org/10.1590/s0102-311x2013000700003 review revisão should acellular pertussis vaccine be recommended to healthcare professionals? by josé cassio de moraes et al.,

http://www.hindawi.com/journals/bmri/2014/541319/ giovanni gabutti, cecilia trucchi, michele conversano, giambattista zivelonghi, and giorgio zoppi, “booster vaccination: the role of reduced antigen content vaccines as a preschool booster,” biomed research international, vol. 2014, article id 541319, 10 pages, 2014. doi:10.1155/2014/541319

http://journal.frontiersin.org/article/10.3389/fpubh.2015.00269/full review article front. public health, 26 november 2015 | http://dx.doi.org/10.3389/fpubh.2015.00269 vaccines through centuries: major cornerstones of global health by inaya hajj hussein et al.,

http://bmcpediatr.biomedcentral.com/articles/10.1186/1471-2431-12-98 pertussis vaccination in child care workers: room for improvement in coverage, policy and practice by kirsty hope et al., bmc pediatrics201212:98 doi: 10.1186/1471-2431-12-98

http://www.scielo.br/scielo.php?script=sci_arttext&pid=s0036-46652009000300002 rev. inst. med. trop. s. paulo vol.51 no.3 são paulo may/june 2009 http://dx.doi.org/10.1590/s0036-46652009000300002 vaccines acellular and "low" pertussis vaccines: adverse events and the role of mutations by hisako g. higashi et al.,

http://europepmc.org/backend/ptpmcrender.fcgi?accid=pmc4890858&blobtype=pdf visser o, hautvast jla, van der velden k,hulscher mejl (2016) intention to accept pertussis vaccination for cocooning: a qualitative study of the determinants. plos one 11(6): e0155861.doi:10.1371/journal.pone.0155861

http://journal.frontiersin.org/article/10.3389/fpls.2012.00142/full mini review article front. plant sci., 27 june 2012 | http://dx.doi.org/10.3389/fpls.2012.00142 madp-rts: versatile virulence factors from bacterial pathogens of plants and mammals by lennart wirthmueller* and mark j. banfield

http://www.scielo.br/scielo.php?script=sci_arttext&pid=s0100-879x2004000100021 http://dx.doi.org/10.1590/s0100-879x2004000100021 braz j med biol res, january 2004, volume 37(1) 151-158 reimmunization after bone marrow transplantation - current recommendations and perspectives by c.m. machado

http://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-015-0382-8 asymptomatic transmission and the resurgence of bordetella pertussis by benjamin m. althouse et al bmc medicine201513:146 doi: 10.1186/s12916-015-0382-8

 

Related videos:

https://www.youtube.com/watch?v=5txv-8-6tw0 what is pertussis?

https://www.youtube.com/watch?v=xlcyqs5vqhq pertussis pathophysiology

https://www.youtube.com/watch?v=qffmdzvwa3o pertussis (whooping cough) psa

https://www.youtube.com/watch?v=9thhr6rbh30 bordetella pertussis

https://www.youtube.com/watch?v=xkavg2_5jxo pertussis and how it happens

https://www.youtube.com/watch?v=dz5jf-5mobe clinical examples of pertussis

https://www.youtube.com/watch?v=s3ozrmgdmmw infant girl with whooping cough

 

 

 

Presentations/quiz/newspaper articles:

http://articles.mercola.com/sites/articles/archive/2016/04/12/pertussis-vaccine.aspx mercola pertussis microbe outsmarts the vaccines as experts argue about why

http://well.blogs.nytimes.com/2016/02/22/why-pertussis-is-making-a-comeback/?_r=0 new york times why pertussis is making a comeback

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