peptic-ulcer
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Peptic Ulcer

Peptic Ulcer

Last Reviewed : 12/24/2020
Peptic Ulcer

Peptic ulcer disease (PUD), also known as a peptic ulcer or stomach ulcer, is a break in the lining of the stomach, first part of the small intestine, or occasionally the lower esophagus. An ulcer in the stomach is known as a gastric ulcer while that in the first part of the intestines is known as a duodenal ulcer. The most common symptoms are waking at night with upper abdominal pain or upper abdominal pain that improves with eating. The pain is often described as a burning or dull ache. Other symptoms include belching, vomiting, weight loss, or poor appetite. About a third of older people have no symptoms. Complications may include bleeding, perforation, and blockage of the stomach. Bleeding occurs in as many as 15% of people.

Common causes include the bacteria Helicobacter pylori and non-steroidal anti-inflammatory drugs (NSAIDs). Other less common causes include tobacco smoking, stress due to serious illness, Behcet disease, Zollinger-Ellison syndrome, Crohn disease and liver cirrhosis, among others. Older people are more sensitive to the ulcer causing effects of NSAIDs. The diagnosis is typically suspected due to the presenting symptoms with confirmation by either endoscopy or barium swallow. H. pylori can be diagnosed by testing the blood for antibodies, a urea breath test, testing the stool for signs of the bacteria, or a biopsy of the stomach. Other conditions that produce similar symptoms include stomach cancer, coronary heart disease, and inflammation of the stomach lining or gallbladder.

Diet does not play an important role in either causing or preventing ulcers. Treatment includes stopping smoking, stopping NSAIDs, stopping alcohol, and medications to decrease stomach acid. The medication used to decrease acid is usually either a proton pump inhibitor (PPI) or an H2 blocker with four weeks of treatment initially recommended. Ulcers due to H. pylori are treated with a combination of medications such as amoxicillin, clarithromycin, and a PPI. Antibiotic resistance is increasing and thus treatment may not always be effective. Bleeding ulcers may be treated by endoscopy, with open surgery typically only used in cases in which it is not successful.

Peptic ulcers are present in around 4% of the population. They newly began in around 53 million people in 2013. About 10% of people develop a peptic ulcer at some point in their life. They resulted in 301,000 deaths in 2013 down from 327,000 deaths in 1990. The first description of a perforated peptic ulcer was in 1670 in Princess Henrietta of England. H. pylori was first identified as causing peptic ulcers by Barry Marshall and Robin Warren in the late 20th century, a discovery for which they received the Nobel Prize in 2005.

We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.

 

 

Basic information:

http://www.webmd.com/digestive-disorders/digestive-diseases-peptic-ulcer-disease web md what is peptic ulcer disease?

https://medlineplus.gov/ency/article/000206.htm medline plus peptic ulcer

http://www.healthline.com/health/stomach-ulcer health line what is a stomach ulcer?

http://www.healthline.com/health/peptic-ulcer health line peptic ulcer

http://patients.gi.org/topics/peptic-ulcer-disease/ american college of gastroenterology peptic ulcer

http://www.mayoclinic.org/diseases-conditions/peptic-ulcer/basics/definition/con-20028643 mayoclinic peptic ulcer

http://www.merckmanuals.com/professional/gastrointestinal-disorders/gastritis-and-peptic-ulcer-disease/peptic-ulcer-disease merck manuals(professional version) peptic ulcer disease

https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/stomach-ulcer better health peptic ulcer

http://kidshealth.org/en/parents/peptic-ulcers.html kids health peptic ulcer

http://umm.edu/health/medical/altmed/condition/peptic-ulcer university of maryland medical center peptic ulcer

http://www.netdoctor.co.uk/conditions/digestive-health/a4918/peptic-ulcers/ net doctor peptic ulcer

http://my.clevelandclinic.org/health/diseases_conditions/hic_peptic_ulcer_disease cleveland clinic peptic ulcer

http://www.bupa.co.uk/health-information/directory/p/peptic-ulcer bupa peptic ulcer

http://www.everydayhealth.com/peptic-ulcer/guide/ everyday health peptic ulcer

http://www.livescience.com/34799-stomach-peptic-gastric-ulcers.html live science stomach ulcers: causes, symptoms & treatments

https://www.healthychildren.org/english/health-issues/conditions/abdominal/pages/peptic-ulcers.aspx healthy children peptic-ulcers

 

Advanced information:

http://www.emedicinehealth.com/peptic_ulcers/article_em.htm emedicine health peptic ulcer

http://www.medicinenet.com/peptic_ulcer/article.htm medicine net peptic ulcer

http://patient.info/in/health/stomach-gastric-ulcer patient stomach (gastric) ulcer

http://emedicine.medscape.com/article/181753-overview medscape peptic ulcer

http://www.medicalnewstoday.com/articles/9273.php medical news today what is a peptic ulcer? what causes peptic ulcers?

http://www.nytimes.com/health/guides/disease/gastric-ulcer/print.html newyork times gastric ulcer in-depth report

http://radiopaedia.org/articles/peptic-ulcer-disease radiopedia peptic ulcer disease

http://www.uptodate.com/contents/peptic-ulcer-disease-beyond-the-basics upto date patient information: peptic ulcer disease (beyond the basics)

http://www.aafp.org/afp/2007/1001/p1005.html peptic ulcer disease by kalyanakrishnan ramakrishnan, md, frcse, and robert c. salinas, md, university of oklahoma health sciences center, oklahoma city, oklahoma am fam physician. 2007 oct 1;76(7):1005-1012.

 

Research:

http://www.phytojournal.com/vol2issue1/issue_may_2013/13.pdf issn 2278- 4136 zdb-number: 2668735-5 ic journal no: 8192 volume 2 issue 1 online available at www.phytojournal.com journal of pharmacognosy and phytochemistry vol. 2 no. 1 2013 www.phytojournal.com page | 235 a review on medicinal plants with anti-ulcer activity by rahul a. wandre et al.,

http://ann-clinmicrob.biomedcentral.com/articles/10.1186/1476-0711-4-1 helicobacter pylori and gastroduodenal pathology: new threats of the old friend by niyaz ahmed and leonardo a sechi annals of clinical microbiology and antimicrobials20054:1 doi: 10.1186/1476-0711-4-1

al dhahab h, mcnabb-baltar j, al-taweel t, barkun a. state-of-the-art management of acute bleeding peptic ulcer disease. saudi j gastroenterol [serial online] 2013 [cited 2016 jul 1];19:195-204. available from: http://www.saudijgastro.com/text.asp?2013/19/5/195/118116

http://europepmc.org/backend/ptpmcrender.fcgi?accid=pmc3191140&blobtype=pdf : ponce j, calvet x, gallach m, ponce m, the esophagitis study group of the asociacio´n espan˜ola de gastroenterologi´a (aeg) (2011) esophagitis in a high h. pylori prevalence area: severe disease is rare but concomitant peptic ulcer is frequent. plos one 6(10): e25051. doi:10.1371/journal.pone.0025051

http://www.hindawi.com/journals/ulcers/2012/896509/ graziella guariso and marco gasparetto, “update on peptic ulcers in the pediatric age,” ulcers, vol. 2012, article id 896509, 9 pages, 2012. doi:10.1155/2012/896509

http://www.mdpi.com/1420-3049/13/12/3198/htm molecules 2008, 13(12), 3198-3223; doi:10.3390/molecules13123198 review:gastric and duodenal antiulcer activity of alkaloids: a review by heloina de sousa falcão et al.,

http://www.sciencedirect.com/science/article/pii/s1015958413001073 nonoperative management for perforated peptic ulcer: who can benefit? by feng cao et al., asian journal of surgery volume 37, issue 3, july 2014, pages 148–153 doi:10.1016/j.asjsur.2013.10.002

http://www.aventinomedicalgroup.com/documents/jccparticle.pdf psychosocial factors in peptic ulcer and inflammatory bowel disease by susan levenstein journal of consulting and clinical psychology, inc. 2002, vol. 70, no. 3, 739–750

 

Related topics:

http://www.top10homeremedies.com/home-remedies/home-remedies-stomach-ulcer.html top 10 home remedies home remedies for a stomach ulcer

 

Other articles:

http://www.scopemed.org/fulltextpdf.php?mno=25509 parrah jd, moulvi ba, gazi ma, makhdoomi dm, athar h, dar s and mir aq (2013) gastric ulceration in dog: a review, world 6(7):449-454, doi:10.5455/vetworld.2013.449-454

 

Related videos:

https://www.youtube.com/watch?v=wargyh_c0mu peptic ulcer disease pathophysiology

https://www.youtube.com/watch?v=lkunokt9b1q how a peptic ulcer develops

https://www.youtube.com/watch?v=ksozu9avcpe peptic ulcer disease explained (usmle tutorial)

https://www.youtube.com/watch?v=ypuv9ef7sse peptic ulcer 3d animation - medical videos

https://www.youtube.com/watch?v=u_r9ixpdeq0 11 home remedies for peptic ulcer

https://www.youtube.com/watch?v=8lypfvevbqu peptic ulcer disease and h. pylori

 

Presentations/quiz/newspaper articles:

http://www.dailymail.co.uk/health/article-35538/why-milk-isnt-answer-stomach-ulcers.html daily mail why milk isn't the answer for stomach ulcers by dr john briffa, daily mail



read more: http://www.dailymail.co.uk/health/article-35538/why-milk-isnt-answer-stomach-ulcers.html#ixzz4fw10dqmy

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