Pemphigus vulgaris

Pemphigus vulgaris

Last Reviewed : 12/24/2020
Pemphigus vulgaris

Pemphigus vulgaris is a chronic blistering skin disease with skin lesions that may initially be pruritic, but invariably become painful. It is classified as a type II hypersensitivity reaction, with the formation of anti-desmosome antibodies that lead to separation of the dermis from the epidermis. Over time, the clinical picture is one of inevitable progression of the disease, with lesions increasing in size and distribution throughout the body, behaving physiologically like a severe burn. Before the advent of modern treatments, mortality for the disease was close to 90%.

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Basic information: pemphigus vulgaris pemphigus vulgaris pemphigus vulgaris pemphigus vulgaris british skin foundation pemphigus vulgaris merck manuals pemphigus vulgaris pemphigus vulgaris skin sight pemphigus vulgaris


Advanced information: pemphigus vulgaris dermnet nz pemphigus vulgaris patient pemphigus vulgaris pemphigus vulgaris acod pemphigus vulgaris nord pemphigus vulgaris med page today rituximab and ivig: possible tx for pemphigus vulgaris? letter in nejm describes long-term remission in 10 patients pemphigus vulgaris in pregnancy cutis. 2014 october;94(4):206-209. kelsey w. salzberg, md; melanie j. gero, md; bruce d. ragsdale, md



pazyar n, feily a, yaghoobi r. macrophage migration inhibitory factor as an incriminating agent in dermatological disorders. indian j dermatol [serial online] 2013 [cited 2016 may 19];58:157. available from: rev. inst. med. trop. s. paulo vol.53 no.2 são paulo mar./apr. 2011 case report:refractory pemphigus vulgaris associated with herpes infection: case report and review by maria luiza figueiredo braga brandão et al

bansal a, tewari a, garg s, kanwal a. anesthetic considerations in pemphigus vulgaris: case series and review of literature. saudi j anaesth [serial online] 2012 [cited 2016 may 19];6:165-8. available from:

de d, kanwar aj. childhood pemphigus. indian j dermatol [serial online] 2006 [cited 2016 may 19];51:89-95. available from:

singh s. evidence-based treatments for pemphigus vulgaris, pemphigus foliaceus, and bullous pemphigoid: a systematic review. indian j dermatol venereol leprol [serial online] 2011 [cited 2016 may 19];77:456-69. available from:

hasan s, kapoor b, siddiqui a, srivastava h, fatima s, akhtar y. mucous membrane pemphigoid with exclusive gingival involvement: report of a case and review of literature. j orofac sci [serial online] 2012 [cited 2016 may 19];4:64-9. available from:

hasan s. desquamative gingivitis - a clinical sign in mucous membrane pemphigoid: report of a case and review of literature. j pharm bioall sci [serial online] 2014 [cited 2016 may 19];6:122-6. available from: our dermatol online. 2013; 4(suppl. 3): 616-618 doi:. 10.7241/ourd.20134.153 pemphigus and psychological stress: a review of the literature by aline bicalho matias, ana maria ferreira roselino

abreu velez am, upegui zapata ya, howard ms. periodic acid-schiff staining parallels the immunoreactivity seen by direct immunofluorescence in autoimmune skin diseases. north am j med sci [serial online] 2016 [cited 2016 may 19];8:151-5. available from: dermatology research and practice
volume 2010 (2010), article id 584353, 7 pages review article:mouse models for blistering skin disorders by radhika ganeshan et al retroperitoneal castleman's tumor and paraneoplastic pemphigus: report of a case and review of the literature by charalambos menenakos et al., world journal of surgical oncology20075:45 doi: 10.1186/1477-7819-5-45 pemphigus vulgaris in pregnancy: a case report and review of literature by ofer fainaru et al., hum. reprod. (2000) 15 (5):1195-1197.doi: 10.1093/humrep/15.5.1195

kar p k, murthy p s, rajagopal r. management of pemphigus vulgaris during acute phase. indian j dermatol venereol leprol [serial online] 2003 [cited 2016 may 21];69:109-13. available from: cahali jb et al. - nail manifestations in pemphigus vulgaris. rev. hosp. clín. fac. med. s. paulo 57(5):229-234, 2002 case reports in dentistry
volume 2015 (2015), article id 593940, 3 pages case report oral lesions: the clue to diagnosis of pemphigus vulgaris by diana kuriachan et al bascones-martinez a, munoz-corcuera m, bascones-ilundain c, esparza-gómez g (2010) oral manifestations of pemphigus vulgaris: clinical presentation, differential diagnosis and management. j clin exp dermatol res 1:112. doi: 10.4172/2155-9554.1000112


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Other articles: skin disease, autoimmune (pemphigus) in dogs provet health care information


Other helpful resources(support groups): pemphigus vulgaris network international pemphigus and pemphigoid foundation


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