Pegets disease of bone/osteitis deformans

Pegets disease of bone/osteitis deformans

Last Reviewed : 12/24/2020

Paget's disease of bone (also termed osteitis deformans or ambiguously, just Paget's disease) is caused by the excessive breakdown and formation of bone, followed by disorganized bone remodeling. This causes affected bone to weaken, resulting in pain, misshapen bones, fractures and arthritis in the joints near the affected bones. Rarely, it can develop into a primary bone cancer known as Paget's sarcoma. Often Paget's disease is localized to only a few bones in the body. The pelvis, femur, and lower lumbar vertebrae are the most commonly affected bones. Paget's disease typically is localized, affecting just one or a few bones, as opposed to osteoporosis, for example, which usually affects all the bones in the body.

A later phase of the disease is characterized by the replacement of normal bone marrow with highly vascular fibrous tissue. Because early diagnosis and treatment is important, after age 40, siblings and children of someone with Paget's disease should have an alkaline phosphatase blood test every two or three years. If the alkaline phosphatase level is above normal, other tests such as a bone-specific alkaline phosphatase test, bone scan, or X-ray can be performed.

Decisions about treating Paget's disease may be complicated as the disease often affects people differently. In addition to this, it is sometimes difficult to predict whether a person with Paget's disease, who shows no signs or symptoms of the disorder, will develop symptoms or complications (such as a bone fracture) in the future. Although there is no cure for Paget's disease, medications (bisphosphonates and calcitonin) can help control the disorder and lessen pain and other symptoms. Medications are often successful in controlling the disorder, especially when started before complications begin.

Paget's disease affects from 1.5 to 8.0 percent of the population, depending on age and country of residence. Paget's disease is rare in people less than 55 years of age. Men are more commonly affected than women (3:2). The disease is named after Sir James Paget.

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Basic information: mayo clinic paget's disease of bone american colege of rheumatology paget's disease of bone nhs uk paget's disease of bone better health paget's disease of bone what is paget’s disease of bone? medline plus paget's disease of bone american academy of orthopedic surgeons paget's disease of bone web md paget's disease of bone arthritis research uk paget's disease of bone merck manuals paget's disease of bone health direct paget's disease of bone new york times paget's disease of bone medbroadcast paget's disease of bone university of maryland medica center paget's disease of bone canoe paget's disease of bone very well paget's disease of bone or osteoarthritis - which is it?


Advanced information: medscape paget disease patient paget's disease of bone medical news today what is paget's disease of bone? medicine net paget's disease of bone cleveland cinic paget's disease of bone national organisation for rare diseases paget's disease of bone paget disease of bone:an update volume 41, no.3, march 2012 pages 100-103 radiopedia paget disease (bone) uptodate patient education: paget disease of bone (osteitis deformans) (beyond the basics) diagnosis and treatment of paget's disease of bone by doron schneider et al., am fam physician. 2002 may 15;65(10):2069-2073. family practise notebook paget's disease of bone dovemed paget’s disease of the bone wheeless online textbook of orthopedics paget's disease of bone


Research: functional bracing for delayed union of a femur fracture associated with paget's disease of the bone in an asian patient: a case report by iori takigami et al., journal of orthopaedic surgery and research20105:33 doi: 10.1186/1749-799x-5-33 ubiquitin-mediated signalling and paget's disease of bone by robert layfield et al., bmc biochemistry20078(suppl 1):s5 doi: 10.1186/1471-2091-8-s1-s5 protocol for stage 2 of the gap study (genetic testing acceptability for paget's disease of bone): a questionnaire study to investigate whether relatives of people with paget's disease would accept genetic testing and preventive treatment if they were available by anne l langston et al., bmc health services research20088:116 doi: 10.1186/1472-6963-8-116 paget's disease of the skull causing hyperprolactinemia and erectile dysfunction: a case report by rachel hepherd and paul e jennings. journal of medical case reports20082:234 doi: 10.1186/1752-1947-2-234 protocol for stage 1 of the gap study (genetic testing acceptability for paget's disease of bone): an interview study about genetic testing and preventive treatment: would relatives of people with paget's disease want testing and treatment if they were available? by anne l langston et al., bmc health services research20066:71 doi: 10.1186/1472-6963-6-71 five-year follow-up of japanese patients with paget's disease of the bone after treatment with low-dose oral alendronate: a case series by kousuke iba et al., journal of medical case reports20104:166 doi: 10.1186/1752-1947-4-166 arq bras endocrinol metab vol.50 no.4 são paulo aug. 2006 update article : paget's disease of bone by luiz griz et al.,


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