Patent ductus arteriosus

Patent ductus arteriosus

Last Reviewed : 12/24/2020
Patent ductus arteriosus


Patent ductus arteriosus (PDA) is a condition wherein the ductus arteriosus fails to close after birth.

Early symptoms are uncommon, but in the first year of life include increased 'work of breathing' and poor weight gain. An uncorrected PDA may lead to congestive heart failure with increasing age.

The ductus arteriosus is a fetal blood vessel that closes soon after birth. In a PDA, the vessel does not close and remains "patent" (open), resulting in irregular transmission of blood between the aorta and the pulmonary artery. PDA is common in newborns with persistent respiratory problems such as hypoxia, and has a high occurrence in premature newborns. Premature newborns are more likely to be hypoxic and have PDA due to underdevelopment of the heart and lungs.

A PDA allows a portion of the oxygenated blood from the left heart to flow back to the lungs by flowing from the aorta (which has higher pressure) to the pulmonary artery. If this shunt is substantial, the neonate becomes short of breath: the additional fluid returning to the lungs increases lung pressure, which in turn increases the energy required to inflate the lungs. This uses more calories than normal and often interferes with feeding in infancy. This condition, as a constellation of findings, is called congestive heart failure.

In some congenital heart defects (such as in transposition of the great vessels) a PDA may need to remain open, as it is the only way that oxygenated blood can mix with deoxygenated blood. In these cases, prostaglandins are used to keep the DA open until surgical correction of the heart defect is completed.

We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.



Basic information: medline plus patent ductus arteriosus national heart lung and blood institute what is patent ductus arteriosus? mayo clinic patent ductus arteriosus about kids health patent ductus arteriosus (pda): closure in the heart catheterization lab kids health patent ductus arteriosus health line patent ductus arteriosus merck manuals(professional version) patent ductus arteriosus cleveland clinic patent ductus arteriosus university of maryland medical center patent ductus arteriosus new york times patent ductus arteriosus


Advanced information: medscape patent ductus arteriosus patient patent ductus arteriosus radiopedia patent ductus arteriosus aiims- nicu protocols 2007

patent ductus arteriosus in preterm neonates by ramesh agarwal, ashok k deorari, vinod k paul patent ductus arteriosus newborn services clinical guideline


Research: unusual presentation for a patent ductus arteriosus by c.d. vizza, r. badagliacca, r. poscia, c. gambardella, b. pezzuto, e. crescenzi, s. papa, f. fedele european respiratory review sep 2009, 18 (113) 174-176; doi: 10.1183/09059180.00003509 eisenmenger syndrome in an adult patient with a large patent ductus arteriosus by konstantinos dimopoulos european respiratory review dec 2013, 22 (130) 558-564; doi: 10.1183/09059180.00007013 congenital heart disease in the newborn requiring early intervention by sin weon yun, m.d. doi: 10.3345/kjp.2011.54.5.183 korean j pediatr 2011;54(5):183-191 park hw, choi y-s, kim ks, kim s-n (2015) chorioamnionitis and patent ductus arteriosus: a systematic review and meta-analysis.plos one 10(9): e0138114. doi:10.1371/journal.pone.0138114 patent ductus arteriosus endarteritis in a 40-year old woman, diagnosed with transesophageal echocardiography. a case report and a brief review of the literature by nikos t kouris et al., cardiovascular ultrasound20031:2 doi: 10.1186/1476-7120-1-2 outcome following patent ductus arteriosus ligation in premature infants: a retrospective cohort analysis by lleona cl lee bmc pediatricsbmc series ¿ open, inclusive and trusted20066:15 doi: 10.1186/1471-2431-6-15

tefera e, qureshi sa, bermudez-canete r, rubio l. percutaneous closure of patent arterial ducts in patients from high altitude: a sub-saharan experience. ann pediatr card [serial online] 2015 [cited 2016 jul 1];8:196-201. available from: ligation of patent ductus arteriosus in low birth weight premature infants: timing for intervention and effectiveness of bed-side surgery by kivanç metin et al., journal of cardiothoracic surgery20127:129 doi: 10.1186/1749-8090-7-129 treatment options for pediatric patent ductus arteriosus:systematic review and meta-analysis by jennifer y. lam et al., journal of perinatology (2006) 26, s14–s18. doi:10.1038/ patent ductus arteriosus: pathophysiology and management by e r hermes-desantis et al., a comparison of ibuprofen and indomethacin for closure of patent ductus arteriosus by bart van overmeire, m.d., ph.d n engl j med 2000; 343:674-681september 7, 2000doi: 10.1056/nejm200009073431001 rev. bras. cardiol. invasiva vol.22 no.4 são paulo oct./dec. 2014 artigos originais percutaneous occlusion of patent ductus arteriosus by juliano rathke et al., yarrabolu tr, syamasundar rao p (2012) transcatheter closure of patent ductus arteriosus. pediat therapeut s5:005. doi: 10.4172/2161-0665.s5-005


Other articles: pet md patent ductus arteriosus corell university college of veterinary medicine patent ductus arteriosus merck vet manual patent ductus arteriosus pet patent ductus arteriosus (pda): a congenital heart defect in puppies vet patent ductus arteriosus patent ductus arteriosus in dogs


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