The term ovarian cancer is used to describe a heterogeneous group of malignant tumors found in the ovary. The most common ovarian cancers are known as epithelial ovarian cancers (EOC). Inherited mutations in the BRCA1 and BRCA2 genes greatly increase a woman's risk of developing ovarian cancer.Ovarian cancer is the most lethal gynecological cancer in industrialized countries, and is the sixth leading cause of cancer deaths in women worldwide.Most ovarian cancers are diagnosed in advanced stages because there are no reliable early symptoms and signs of ovarian cancer. Even in more advanced tumors, symptoms and signs are vague and nonspecific.Ovarian cancer typically occurs in peri- and postmenopausal women, with an average of 54 years at diagnosis.
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http://bmcmedicine.biomedcentral.com/articles/10.1186/1741-7015-10-9. biomed central, diindolylmethane suppresses ovarian cancer growth and potentiates the effect of cisplatin in tumor mouse model by targeting signal transducer and activator of transcription 3 (stat3), bmc medicine 2012 10:9, doi: 10.1186/1741-7015-10-9, kandala and srivastava