Neuro Syphilis

Neuro Syphilis

Last Reviewed : 12/24/2020

Neurosyphilis is an infection of the brain or spinal cord caused by the spirochete Treponema pallidum. It usually occurs in people who have had chronic, untreated syphilis, usually about 10 to 20 years after first infection and develops in about 25%–40% of persons who are not treated. The United States' Centers for Disease Control and Prevention (CDC) advises that neurosyphilis can occur at any stage of a syphilis infection.

We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.


Basic information: healthline neurosyphilis medline plus neurosyphilis national institute of neurologial disorders and stroke neurosyphilis web md neurosyphilis - topic overview new york times neurosyphilis neurosyphilis university of maryland medical center neurosyphilis symptoma neurosyphilis health link bc neurosyphilis


Advanced information: medscape neurosyphilis overview of syphilis of the cns ward 86 management recommendations management of neurosyphilis september 2014 updated april 2016 contributors: mark jacobson, md.,sulggi lee, md, phd dove med neurosyphilis – tabes dorsalis right diagnosis neurosyphilis med merits neurosyphilis clinical manifestations emedmd neurosyphilis and neuro-aids histo pathology pathology of neurosyphilis radiopedia neurosyphilis diagnosis and management of syphilis by david l. brown, maj, mc, usa, and jennifer e. frank, cpt, mc, usa dewitt army community hospital, fort belvoir, virginia am fam physician. 2003 jul 15;68(2):283-290. patient syphilis


Research: sarah e. parker and john h. pula, “neurosyphilis presenting as asymptomatic optic perineuritis,” case reports in ophthalmological medicine, vol. 2012, article id 621872, 4 pages, 2012. doi:10.1155/2012/621872 neurosyphilis: diagnosis and response to treatment by daniel m. musher clin infect dis. (2008) 47 (7):900-902.doi: 10.1086/591535 diagnosis of neurosyphilis: new tools by sparling, p. frederick md sexually transmitted diseases: may 2010 - volume 37 - issue 5 - pp 288-289 doi: 10.1097/olq.0b013e3181d90445 shagufta ahsan and joesph burrascano, “neurosyphilis: an unresolved case of meningitis,” case reports in infectious diseases, vol. 2015, article id 634259, 6 pages, 2015. doi:10.1155/2015/634259 symptomatic early neurosyphilis among hiv-positive men who have sex with men --- four cities, united states, january 2002--june 2004 mmwr weekly june 29, 2007 / 56(25);625-628 neurosyphilis with dementia and bilateral hippocampal atrophy on brain magnetic resonance imaging by shima mehrabian et al., bmc neurologybmc series ¿ open, inclusive and trusted201212:96 doi: 10.1186/1471-2377-12-96

pavithran k. computer tomographic findings in neurosyphilis. indian j dermatol venereol leprol [serial online] 1993 [cited 2016 jul 1];59:122-4. available from: indian j med res 122, september 2005, pp 249-253neurosyphilis in a tertiary care hospital in north india by sunil sethi et al., neurosyphilis: a historical perspective and review by khalil g. ghanem cns neuroscience & therapeuticsvolume 16, issue 5, version of record online: 8 jul 2010 mri of neurosyphilis presenting as brain tumor: a case report by yuling xi et al., radiology of infectious diseases volume 2, issue 4, december 2015, pages 197–200 doi:10.1016/j.jrid.2015.11.006 psychiatric manifestations as primary symptom of neurosyphilis among hiv-negative patients by li-rong lin, et al., the journal of neuropsychiatry and clinical neurosciences 2014; 26:233–240 j neurol neurosurg psychiatry 2004;75:1727-1730 doi:10.1136/jnnp.2004.031922 neurosyphilis in the modern era by m timmermans, j carr neurosyphilis as a cause of facial and vestibulocochlear nerve dysfunction: mr imaging features by michelle m. smitha and james c. andersona ajnr 2000 21: 1673-1675 arq. neuro-psiquiatr. vol.64 no.1 são paulo mar. 2006 generalized periodic eeg activity in two cases of neurosyphilis by renato anghinah et al., did you rule out neurosyphilis? by ricardo nitrini et al., dement neuropsychol 2010 december;4(4):338-345 clinical prediction and diagnosis of neurosyphilis in hiv-infected patients with early syphilis by jeannot dumaresq et al., j. clin. microbiol. december 2013 vol. 51 no. 12 4060-4066 csf tests for the diagnosis of neurosyphilis in hiv by christina m. marra psychosis or simply a new manifestation of neurosyphilis? by e kararizouet al., the journal of international medical research 2006; 34: 335 – 337

ozben s, erol c, ozer f, tiras r. chorea as the presentating feature of neurosyphilis. neurol india [serial online] 2009 [cited 2016 jul 2];57:347-9. available from:


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