neuro-syphilis
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Neuro Syphilis

Neuro Syphilis

Last Reviewed : 12/24/2020

Neurosyphilis is an infection of the brain or spinal cord caused by the spirochete Treponema pallidum. It usually occurs in people who have had chronic, untreated syphilis, usually about 10 to 20 years after first infection and develops in about 25%–40% of persons who are not treated. The United States' Centers for Disease Control and Prevention (CDC) advises that neurosyphilis can occur at any stage of a syphilis infection.

We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.

 

Basic information:

http://www.healthline.com/health/neurosyphilis healthline neurosyphilis

https://www.nlm.nih.gov/medlineplus/ency/article/000703.htm medline plus neurosyphilis

http://www.ninds.nih.gov/disorders/neurosyphilis/neurosyphilis.htm national institute of neurologial disorders and stroke neurosyphilis

http://www.webmd.com/brain/tc/neurosyphilis-topic-overview web md neurosyphilis - topic overview

http://www.nytimes.com/health/guides/disease/neurosyphilis/overview.html new york times neurosyphilis

https://www.cdph.ca.gov/programs/std/documents/neurosyphilisguide.pdf neurosyphilis

http://umm.edu/health/medical/ency/articles/neurosyphilis university of maryland medical center neurosyphilis

https://www.symptoma.com/en/info/neurosyphilis symptoma neurosyphilis

http://www.healthlinkbc.ca/healthtopics/content.asp?hwid=hw195457 health link bc neurosyphilis

 

Advanced information:

http://emedicine.medscape.com/article/1169231-overview medscape neurosyphilis overview of syphilis of the cns

http://hivinsite.ucsf.edu/insite?page=md-ward86-neurosyphilis ward 86 management recommendations management of neurosyphilis september 2014 updated april 2016 contributors: mark jacobson, md.,sulggi lee, md, phd

http://www.dovemed.com/neurosyphilis-tabes-dorsalis/ dove med neurosyphilis – tabes dorsalis

http://www.rightdiagnosis.com/n/neurosyphilis/intro.htm right diagnosis neurosyphilis

http://www.medmerits.com/index.php/article/neurosyphilis/p2 med merits neurosyphilis clinical manifestations

http://www.emedmd.com/content/neurosyphilis-and-neuro-aids emedmd neurosyphilis and neuro-aids

http://www.histopathology-india.net/neusyp.htm histo pathology india.net pathology of neurosyphilis

http://radiopaedia.org/cases/neurosyphilis radiopedia neurosyphilis

http://www.aafp.org/afp/2003/0715/p283.html diagnosis and management of syphilis by david l. brown, maj, mc, usa, and jennifer e. frank, cpt, mc, usa dewitt army community hospital, fort belvoir, virginia am fam physician. 2003 jul 15;68(2):283-290.

http://patient.info/health/syphilis-leaflet patient syphilis

 

Research:

http://www.hindawi.com/journals/criopm/2012/621872/ sarah e. parker and john h. pula, “neurosyphilis presenting as asymptomatic optic perineuritis,” case reports in ophthalmological medicine, vol. 2012, article id 621872, 4 pages, 2012. doi:10.1155/2012/621872

http://cid.oxfordjournals.org/content/47/7/900.full neurosyphilis: diagnosis and response to treatment by daniel m. musher clin infect dis. (2008) 47 (7):900-902.doi: 10.1086/591535

http://journals.lww.com/stdjournal/fulltext/2010/05000/diagnosis_of_neurosyphilis__new_tools.3.aspx diagnosis of neurosyphilis: new tools by sparling, p. frederick md sexually transmitted diseases: may 2010 - volume 37 - issue 5 - pp 288-289 doi: 10.1097/olq.0b013e3181d90445

http://www.hindawi.com/journals/criid/2015/634259/ shagufta ahsan and joesph burrascano, “neurosyphilis: an unresolved case of meningitis,” case reports in infectious diseases, vol. 2015, article id 634259, 6 pages, 2015. doi:10.1155/2015/634259

https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5625a1.htm symptomatic early neurosyphilis among hiv-positive men who have sex with men --- four cities, united states, january 2002--june 2004 mmwr weekly june 29, 2007 / 56(25);625-628

http://bmcneurol.biomedcentral.com/articles/10.1186/1471-2377-12-96 neurosyphilis with dementia and bilateral hippocampal atrophy on brain magnetic resonance imaging by shima mehrabian et al., bmc neurologybmc series ¿ open, inclusive and trusted201212:96 doi: 10.1186/1471-2377-12-96

pavithran k. computer tomographic findings in neurosyphilis. indian j dermatol venereol leprol [serial online] 1993 [cited 2016 jul 1];59:122-4. available from: http://www.ijdvl.com/text.asp?1993/59/3/122/3904

http://medind.nic.in/iby/t05/i9/ibyt05i9p249.pdf indian j med res 122, september 2005, pp 249-253neurosyphilis in a tertiary care hospital in north india by sunil sethi et al.,

http://onlinelibrary.wiley.com/doi/10.1111/j.1755-5949.2010.00183.x/pdf neurosyphilis: a historical perspective and review by khalil g. ghanem cns neuroscience & therapeuticsvolume 16, issue 5, version of record online: 8 jul 2010

http://www.sciencedirect.com/science/article/pii/s235262111500087x mri of neurosyphilis presenting as brain tumor: a case report by yuling xi et al., radiology of infectious diseases volume 2, issue 4, december 2015, pages 197–200 doi:10.1016/j.jrid.2015.11.006

http://neuro.psychiatryonline.org/doi/pdf/10.1176/appi.neuropsych.13030064 psychiatric manifestations as primary symptom of neurosyphilis among hiv-negative patients by li-rong lin, m.med et al., the journal of neuropsychiatry and clinical neurosciences 2014; 26:233–240

http://jnnp.bmj.com/content/75/12/1727.full j neurol neurosurg psychiatry 2004;75:1727-1730 doi:10.1136/jnnp.2004.031922 neurosyphilis in the modern era by m timmermans, j carr

http://www.ajnr.org/content/21/9/1673.full neurosyphilis as a cause of facial and vestibulocochlear nerve dysfunction: mr imaging features by michelle m. smitha and james c. andersona ajnr 2000 21: 1673-1675

http://www.scielo.br/scielo.php?script=sci_arttext&pid=s0004-282x2006000100025 arq. neuro-psiquiatr. vol.64 no.1 são paulo mar. 2006 http://dx.doi.org/10.1590/s0004-282x2006000100025 generalized periodic eeg activity in two cases of neurosyphilis by renato anghinah et al.,

http://www.demneuropsy.com.br/imagebank/pdf/v4n4a14.pdf did you rule out neurosyphilis? by ricardo nitrini et al., dement neuropsychol 2010 december;4(4):338-345

http://jcm.asm.org/content/51/12/4060.full clinical prediction and diagnosis of neurosyphilis in hiv-infected patients with early syphilis by jeannot dumaresq et al., j. clin. microbiol. december 2013 vol. 51 no. 12 4060-4066

https://www.med.unc.edu/neurology/divisions/neuroaids/conferences-1/ana-ii/cmarratanzania.pdf csf tests for the diagnosis of neurosyphilis in hiv by christina m. marra

http://imr.sagepub.com/content/34/3/335.full.pdf psychosis or simply a new manifestation of neurosyphilis? by e kararizouet al., the journal of international medical research 2006; 34: 335 – 337

ozben s, erol c, ozer f, tiras r. chorea as the presentating feature of neurosyphilis. neurol india [serial online] 2009 [cited 2016 jul 2];57:347-9. available from: http://www.neurologyindia.com/text.asp?2009/57/3/347/53277

 

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https://www.youtube.com/watch?v=qgaczngnl9s argyll robertson pupil (neurosyphilis)

https://www.youtube.com/watch?v=kdxqmvol9wq what is tertiary syphilis?

https://www.youtube.com/watch?v=zyysyct8fhu tabes dorsalis - syphilis

 

Presentations/quiz/newspaper articles:

http://blogs.discovermagazine.com/bodyhorrors/2014/05/31/pyromania-syphilis-malaria/#.v3cru9kuesq discover pyromania! on neurosyphilis and fighting fire with fire.

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