Necrotising Fascitis

Necrotising Fascitis

Last Reviewed : 12/24/2020
Necrotising Fascitis

Necrotising fascitis (NF), commonly known as flesh-eating disease, is a rare infection of the deeper layers of skin and subcutaneous tissues which easily spreads across the fascial plane within the subcutaneous tissue. Necrotising fasciitis is a severe disease of sudden onset that progresses rapidly.

It occurs more often in the immune compromised due to conditions such as diabetes or cancer. The disease is classified into four types, depending on the infecting organism. The most common type is caused by a mixture of bacterial types, and commonly occurs at sites of surgery or trauma, usually in abdominal or perineal areas and accounts for 55-75% of cases. Since 2001, a form of monomicrobial necrotizing fasciitis which is particularly difficult to treat has been observed with increasing frequency caused by methicillin-resistant Staphylococcus aureus (MRSA).

It is usually treated with surgical debridement or amputation, and intravenous antibiotics. Delays in surgery are associated with higher mortality.

There are 0.04 cases per 1000 per year in the US. The most consistent feature of necrotising fasciitis was first described in 1952 as necrosis of the subcutaneous tissue and fascia with relative sparing of the underlying muscle.

We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.


Basic information: cdc necrotizing fasciitis: a rare disease, especially for the healthy web md topic overview health line necrotizing fasciitis (soft tissue inflammation) medline plus necrotizing fasciitis nhs uk necrotizing fasciitis health link bc necrotizing fasciitis(flesh-eating disease) merck manuals(professional version) necrotizing subcutaneous infection live science what is flesh-eating bacteria? every day health what is necrotizing fasciitis? health central necrotizing fasciitis


Advanced information: medscape necrotizing fasciitis medicine necrotizing fasciitis (flesh-eating disease) derm net nz necrotizing fasciitis patient necrotizing fasciitis national organisation for rare diseases necrotizing fasciitis life in the fast lane necrotizing fasciitis american academy of ophthalmology necrotizing fasciitis necrotizing fasciitis by lisa banks radiopedia necrotizing fasciitis ortho bullets necrotizing fasciitis emdocs necrotizing fasciitis: pearls & pitfalls medical news today what is necrotizing fasciitis? what is flesh-eating disease? physiopedia necrotizing fasciitis (flesh eating disease) wheelees textbook of orthopedics necrotizing fasciitis


Research: pradeep soni, anil haripriya, santosh uddesh. “fournier’s gangrene: review of 57 cases in tertiary institution”. journal of evidence based medicine and healthcare; volume 2, issue 38, september 21, 2015; page: 6068-6072, doi: 10.18410/jebmh/2015/837 suresh karlatti, uma r. b. “necrotising fascitis 100 cases studied between 2008-2010”. journal of evolution of medical and dental sciences 2014; vol. 3, issue 69, december 11; page: 14818-14823, doi:10.14260/jemds/2014/3990

osunde od, akhiwu bi, efunkoya aa, adebola ar, iyogun ca, arotiba jt. management of fascial space infections in a nigerian teaching hospital: a 4-year review. niger med j [serial online] 2012 [cited 2016 jun 29];53:12-5. available from:

padmaja i j, ramani t v, kalyani s. cutaneous zygomycosis - necrotising fascitis due to saksenaea vasiformis. indian j med microbiol [serial online] 2006 [cited 2016 jun 29];24:58-60. available from:

padmaja i j, ramani t v, kalyani s. cutaneous zygomycosis - necrotising fascitis due to saksenaea vasiformis. indian j med microbiol [serial online] 2006 [cited 2016 jun 29];24:58-60. available from:

shaikh n. necrotizing fasciitis: a decade of surgical intensive care experience. indian j crit care med [serial online] 2006 [cited 2016 jun 30];10:225-9. available from: necrotising fasciitis of the breast: a rare primary case with conservation of the nipple and literature review by bob yang et al., jpras open volume 6, december 2015, pages 15–19 doi:10.1016/j.jpra.2015.05.002 abhishek vijayakumar, rajeev pullagura, and durganna thimmappa, “necrotizing fasciitis: diagnostic challenges and current practices,” isrn infectious diseases, vol. 2014, article id 208072, 8 pages, 2014. doi:10.1155/2014/208072 necrotizing fasciitis of the lower extremity: a case report and current concept of diagnosis and management by ga naqvi et al., scandinavian journal of trauma, resuscitation and emergency medicine200917:28 doi: 10.1186/1757-7241-17-28 necrotizing fasciitis by j. brett fugitt, md, michael l. puckett, md, michael m. quigley, md, phd, and stewart m. kerr, md september 2004 volume 24, issue 5 doi: eye (2012) 26, 463–467; doi:10.1038/eye.2011.241; published online 9 december 2011 multidisciplinary management of periocular necrotising fasciitis: a series of 11 patients by k tambe, a tripathi, j burns and r sampath review article front. surg., 29 september 2014 | current concepts in the management of necrotizing fasciitis by evangelos p. misiakos et al.,

sadasivan j, maroju nk, balasubramaniam a. necrotizing fasciitis. indian j plast surg [serial online] 2013 [cited 2016 jun 30];46:472-8. available from: necrotizing fasciitis by rukshini puvanendran, mmed fcfp mb bs, jason chan meng huey, mb bs and shanker pasupathy, frcs mb bs canadian family physicianoctober 2009 vol. 55 no. 10981-987

chauhan d, arora r, das s, shroff d, narula r. bilateral periorbital necrotizing fasciitis following exposure to holi colors: a case report. indian j ophthalmol [serial online] 2007 [cited 2016 jun 30];55:373-4. available from: krebs vlj et al. - necrotizing fasciitis in a newborn infant: a case report.rev. hosp. clín. fac. med. s. paulo 56(2):59-62, 2001.




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Presentations/quiz/newspaper articles: the conversation explainer: what causes necrotising fasciitis, the flesh-eating bug? fox news necrotizing fasciitis: new treatment discovered for deadly flesh-eating disease express uk man eaten alive by necrotizing fasciitis praises surgeon for saving his penis the daily beast necrotizing fasciitis: life after flesh-eating bacteria ib times flesh-eating bacteria from the ocean? necrotizing fasciitis coming to us beaches this summer cnn flesh-eating condition caused by common bacteria mirror overweight man survives deadly flesh-eating bug because of his extra bulk cbs news aimee copeland, 24, battles flesh-eating necrotizing fasciitis following zip-lining accident

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