narcolepsy
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Narcolepsy

Narcolepsy

Last Reviewed : 12/24/2020
Narcolepsy

Narcolepsy is a chronic neurological disorder involving the loss of the brain's ability to regulate sleep-wake cycles. Symptoms include excessive daytime sleepiness, comparable to how people who do not have narcolepsy feel after 24–48 hours of sleep deprivation, as well as disturbed sleep which often is confused with insomnia. Another common symptom of narcolepsy is cataplexy, a sudden and transient episode of muscle weakness accompanied by full conscious awareness, typically (though not necessarily) triggered by emotions such as laughing, crying, terror, etc. affecting roughly 70% of people who have narcolepsy.

The system which regulates sleep, arousal, and transitions between these states in humans is composed of three interconnected subsystems: the orexin projections from the lateral hypothalamus, the reticular activating system, and the ventrolateral preoptic nucleus. In narcoleptic individuals, these systems are all associated with impairments due to a greatly reduced number of hypothalamic orexin projection neurons and significantly fewer orexin neuropeptides in cerebrospinal fluid and neural tissue, compared to non-narcoleptic individuals. Those with narcolepsy generally experience the REM stage of sleep within five minutes of falling asleep, while people who do not have narcolepsy (unless they are significantly sleep deprived) do not experience REM until after a period of slow-wave sleep, which lasts for about the first hour or so of a sleep cycle.

It is most common between ages 40 and 50 and may decline after age 60. The term narcolepsy derives from the French wordnarcolepsie created by the French physician Jean-Baptiste-Édouard Gélineau by combining the Greek ????? (narke, "numbness" or "stupor"),[9] and ????? (lepsis), "attack" or "seizure".

We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.

 

Basic information:

http://www.webmd.com/sleep-disorders/guide/narcolepsy web md narcolepsy

http://www.ninds.nih.gov/disorders/narcolepsy/detail_narcolepsy.htm national institute of neurological disorders and sleep narcolepsy

http://www.sleepeducation.org/essentials-in-sleep/narcolepsy/overview-facts sleep education narcolepsy

http://www.nhs.uk/conditions/narcolepsy/pages/introduction.aspx nhs uk narcolepsy

http://www.mayoclinic.org/diseases-conditions/narcolepsy/basics/definition/con-20027429 mayo clinic narcolepsy definition

http://www.helpguide.org/articles/sleep/narcolepsy.htm help guide narcolepsy

http://umm.edu/health/medical/reports/articles/narcolepsy university of maryland medical center narcolepsy

http://www.emedicinehealth.com/narcolepsy/article_em.htm emedicine health narcolepsy

http://www.healthline.com/health/narcolepsy health line narcolepsy

http://my.clevelandclinic.org/childrens-hospital/health-info/diseases-conditions/hic-narcolepsy-in-children cleveland clinic narcolepsy in children

https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/sleep-narcolepsy better health sleep - narcolepsy

https://www.sleepassociation.org/patients-general-public/narcolepsy/ american sleep association narcolepsy

http://www.everydayhealth.com/narcolepsy/guide/ everyday health what is narcolepsy?

https://www.verywell.com/what-is-narcolepsy-3014795 very well narcolepsy symptoms, causes, and treatments

 

Advanced information:

http://emedicine.medscape.com/article/1188433-overview medscape narcolepsy

http://www.medicinenet.com/narcolepsy/article.htm medicine net.com narcolepsy

http://www.nytimes.com/health/guides/disease/narcolepsy/print.html new york times narcolepsy in-depth report

http://psychcentral.com/disorders/narcolepsy-symptoms/ psych central narcolepsy symptoms

http://patient.info/health/narcolepsy-and-cataplexy-leaflet patient narcolepsy and cataplexy

http://www.medicalnewstoday.com/articles/155244.php medical news today narcolepsy: causes, symptoms and treatments

http://rarediseases.org/rare-diseases/narcolepsy/ national organisation for rare diseases narcolepsy

http://www.healthcommunities.com/narcolepsy/what-is-narcolepsy.shtml health communities narcolepsy

 

Research:

http://www.ovpjournal.org/uploads/2/3/8/9/23898265/ovp2-3_article_liechty_web.pdf liechty j. sleeping beauty gets an eye exam: a case report and literature review on narcolepsy. optom vis perf 2014;2(3):126-9

http://www.pediatricneurologybriefs.com/articles/10.15844/pedneurbriefs-22-11-4/ millichap, j.g., (2008). diagnosis and management of narcolepsy reviewed. pediatric neurology briefs. 22(11), pp.84–85. doi: http://doi.org/10.15844/pedneurbriefs-22-11-4

http://europepmc.org/backend/ptpmcrender.fcgi?accid=pmc4847913&blobtype=pdf : lamb f, ploner a, fink k, maeurer m,bergman p, piehl f, et al. (2016) no evidence for disease history as a risk factor for narcolepsy after a(h1n1)pdm09 vaccination. plos one 11(4): e0154296. doi:10.1371/journal.pone.0154296

http://www.hindawi.com/journals/sd/2014/271802/ lourdes m. delrosso, andrew l. chesson, and romy hoque, “manual characterization of sleep spindle index in patients with narcolepsy and idiopathic hypersomnia,” sleep disorders, vol. 2014, article id 271802, 4 pages, 2014. doi:10.1155/2014/271802

http://www.hindawi.com/journals/ije/2010/519607/ hermann l. müller, “increased daytime sleepiness in patients with childhood craniopharyngioma and hypothalamic tumor involvement: review of the literature and perspectives,” international journal of endocrinology, vol. 2010, article id 519607, 7 pages, 2010. doi:10.1155/2010/519607

http://www.hindawi.com/journals/crj/2005/341295/abs/ b lockrane, p bhatia, and robin gore, “successful treatment of narcolepsy and cataplexy: a review,”canadian respiratory journal, vol. 12, no. 4, pp. 225-227, 2005. doi:10.1155/2005/341295

http://journal.frontiersin.org/article/10.3389/fneur.2014.00165/full review article front. neurol., 11 september 2014 | http://dx.doi.org/10.3389/fneur.2014.00165 cortical–subcortical interactions in hypersomnia disorders: mechanisms underlying cognitive and behavioral aspects of the sleep–wake cycle by linda j. larson-prior et al.,

http://www.ijpsr.info/docs/ijpsr15-06-12-001.pdf mechanisms of sleep-wake cycle and genetics of sleep disorders. a review. by robel abay.. international journal of pharma sciences and research (ijpsr) issn : 0975-9492 vol 6 no 12 dec 2015

http://europepmc.org/backend/ptpmcrender.fcgi?accid=pmc3849275&blobtype=pdf sheng p, hou l, wang x, wang x, huang c, et al. (2013) efficacy of modafinil on fatigue and excessive daytime sleepiness associated with neurological disorders: a systematic review and meta-analysis. plos one 8(12): e81802. doi:10.1371/journal.pone.0081802

http://www.scopemed.org/fulltextpdf.php?mno=223609 orexin receptors: a journey through their discovery to the development of suvorexant, the new sleeping pill by anandabaskar nishanthi et al., doi: http://dx.doi.org/10.18203/2319-2003.ijbcp20161493 int j basic clin pharmacol. 2016 jun;5(3):573-578

 

Other articles:

http://www.petmd.com/dog/conditions/neurological/c_multi_narcolepsy_cataplexy pet md narcolepsy and cataplexy in dogs

 

Related videos:

https://www.youtube.com/watch?v=onacrpt9bb4 what is narcolepsy?

https://www.youtube.com/watch?v=ucpf_oyvs4e what is narcolepsy?

https://www.youtube.com/watch?v=zippqnh1jzg diagnosing narcolepsy

https://www.youtube.com/watch?v=w1ccfzdx9ge treatment of narcolepsy

https://www.youtube.com/watch?v=z0erkpwkz88 narcolepsy

 

Presentations/quiz/newspaper articles:

https://www.theguardian.com/science/2015/jun/15/narcolepsy-and-the-swine-flu-vaccine-the-girl-who-falls-asleep-40-times-a-day narcolepsy and the swine flu vaccine: the girl who falls asleep 40 times a day

http://www.huffingtonpost.com/entry/dear-people-with-narcolepsy-you-are-awesome_b_9985598.html?section=india dear people with narcolepsy, you are awesome!

http://www.theatlantic.com/health/archive/2014/04/portraits-of-narcolepsy-in-new-york-city/360981/ portraits of narcolepsy in new york city

http://theweek.com/articles/576595/simpsons-shows-why-narcolepsy-no-laughing-matter the simpsons shows why narcolepsy is no laughing matter

http://www.irishtimes.com/life-and-style/people/this-is-the-world-of-narcolepsy-1.1733649 this is the world of narcolepsy

http://www.dailymail.co.uk/news/article-3224953/schoolboy-11-left-unable-smile-laugh-without-suffering-narcolepsy-fits-given-nasal-spray-flu-vaccine-government-scheme.html schoolboy, 11, has been left unable to smile or laugh without suffering narcolepsy fits after he was given a nasal spray flu vaccine as part of a government scheme

read more: http://www.dailymail.co.uk/news/article-3224953/schoolboy-11-left-unable-smile-laugh-without-suffering-narcolepsy-fits-given-nasal-spray-flu-vaccine-government-scheme.html#ixzz4d46ngnkp
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http://news.bbc.co.uk/2/hi/health/4081225.stm immune system link to narcolepsy

http://www.nursingtimes.net/roles/childrens-nurses/hpa-warns-of-link-between-narcolepsy-and-swine-flu-vaccine/5055482.fullarticle hpa warns of link between narcolepsy and swine flu vaccine

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