Myocardial infarction is the irreversible death (necrosis) of heart muscle secondary to prolonged lack of oxygen supply (ischemia). This is because there are actually a range of conditions that can be caused by a sudden reduction in blood flow in a coronary artery. This range of conditions has an overall term called acute coronary syndrome (ACS). Approximately 1.5 million cases of MI occur annually in the United States. Coronary artery disease (CAD) is the leading cause of death in the United States; approximately 500,000-700,000 deaths related to CAD occur each year, making it the cause of death in an estimated one third of all deaths in the population for those older than 35 years
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