Myelofibrosis: Symptoms and Causes- Mdadvices.com

myelofibrosis

Myelofibrosis

Last Reviewed : 12/24/2020

Myelofibrosis, also known as osteomyelofibrosis, is a rare bone marrow cancer. It is currently classified as a myeloproliferative neoplasm, in which the proliferation of an abnormal clone of hematopoietic stem cells in the bone marrow and other sites results infibrosis, or the replacement of the marrow with scar tissue.

The term myelofibrosis alone usually refers to primary myelofibrosis (PMF), also known as chronic idiopathic myelofibrosis(cIMF); the terms idiopathic and primary mean that in these cases the disease is of unknown or spontaneous origin. This is in contrast with myelofibrosis that develops secondary to polycythemia vera or essential thrombocythaemia. Myelofibrosis is a form ofmyeloid metaplasia, which refers to a change in cell type in the blood-forming tissue of the bone marrow, and often the two terms are used synonymously. The terms Agnogenic myeloid metaplasia and myelofibrosis with myeloid metaplasia (MMM) are also used to refer to myelofibrosis.

We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.

Basic information:

http://www.mayoclinic.org/diseases-conditions/myelofibrosis/basics/definition/con-20027210 mayo clinic myelofibrosis definition

http://www.leukaemia.org.au/blood-cancers/myeloproliferative-neoplasms-mpn/primary-myelofibrosis lekemia foundation primary myelofibrosis

https://www.nlm.nih.gov/medlineplus/ency/article/000531.htm medline plus myelofibrosis

http://www.merckmanuals.com/professional/hematology-and-oncology/myeloproliferative-disorders/primary-myelofibrosis merck manuals(professional version) primary myelofibrosis

http://my.clevelandclinic.org/health/diseases_conditions/hic-myelofibrosis cleveland clinic myelofibrosis

http://www.webmd.com/brain/myelofibrosis-idiopathic web md myelofibrosis

http://www.nytimes.com/health/guides/disease/primary-myelofibrosis/overview.html new york times primary myelofibrosis

http://umm.edu/health/medical/ency/articles/myelofibrosis university of maryland medical center myelofibrosis

Advanced information:

http://emedicine.medscape.com/article/197954-overview medscape primary myelofibrosis

http://patient.info/doctor/myelofibrosis patient myelofibrosis

http://rarediseases.org/rare-diseases/primary-myelofibrosis/ primary myelofibrosis

http://www.oncolink.org/types/article.cfm?c=76&id=9633 oncolink myelofibrosis

http://www.cancerresearchuk.org/about-cancer/cancers-in-general/cancer-questions/myelofibrosis cancer research uk myelofibrosis

http://radiopaedia.org/articles/myelofibrosis radiopedia myelofibrosis

http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/hematology-oncology/chronic-myeloproliferative-disorders/ myeloproliferative neoplasms

http://www.healio.com/hematology-oncology/myeloproliferative-neoplasms/news/print/hemonc-today/%7b6e6c6272-1f1c-4979-8504-58fd539c18af%7d/myelofibrosis-symptom-control-takes-significant-step-forward-with-ruxolitinib-approval myelofibrosis symptom control takes ‘significant’ step forward with ruxolitinib approval

https://www.guideline.gov/content.aspx?id=37871 ahro guideline summary

http://bloodref.com/myeloid/mpd/myelofibrosis-prognosis blood ref myelofibrosis prognosis dipss, iwg-mrt and lille prognostic scores for myelofibrosis

Research:

http://www.hindawi.com/journals/ah/2015/848473/ keith l. davis, isabelle côté, james a. kaye, estella mendelson, haitao gao, and julian perez ronco, “real-world assessment of clinical outcomes in patients with lower-risk myelofibrosis receiving treatment with ruxolitinib,” advances in hematology, vol. 2015, article id 848473, 9 pages, 2015. doi:10.1155/2015/848473

http://jhoonline.biomedcentral.com/articles/10.1186/1756-8722-5-43 splenomegaly in myelofibrosis—new options for therapy and the therapeutic potential of janus kinase 2 inhibitors by jasleen randhawa et al., journal of hematology & oncology20125:43 doi: 10.1186/1756-8722-5-43

malhotra h. janus activated kinase inhibition in myelofibrosis. indian j cancer [serial online] 2012 [cited 2016 jun 29];49:260-5. available from: http://www.indianjcancer.com/text.asp?2012/49/3/260/104482

dewan u, kumari n, jaiswal a, behari s, jain m. extramedullary hemopoiesis with undiagnosed, early myelofibrosis causing spastic compressive myelopathy: case report and review. indian j orthop [serial online] 2010 [cited 2016 jun 29];44:98-103. available from: http://www.ijoonline.com/text.asp?2010/44/1/98/57281

http://www.hindawi.com/journals/crihem/2012/207537/ ayed a. algarni, mojtaba akhtari, and kai fu, “myelodysplastic syndrome with myelofibrosis transformed to a precursor b-cell acute lymphoblastic leukemia: a case report with review of the literature,” case reports in hematology, vol. 2012, article id 207537, 6 pages, 2012. doi:10.1155/2012/207537

http://rmmj.org.il/pages/articlehtm.aspx?manuid=432 calreticulin mutations in myeloproliferative neoplasms by noa lavi, m.d. rambam maimonides medical journal 2014 october; 5(4): e0035. issn: 2076-9172

http://mrmjournal.biomedcentral.com/articles/10.1186/2049-6958-5-4-267 pulmonary hypertension diagnosed by echocardiography during idiopathic myelofibrosis. a case report and a brief review of the literature by claudio perrone et al., multidisciplinary respiratory medicine20105:267 doi: 10.1186/2049-6958-5-4-267

http://www.scielo.br/scielo.php?script=sci_arttext&pid=s1807-59322013000300010 clinics vol.68 no.3 são paulo 2013 http://dx.doi.org/10.6061/clinics/2013(03)oa09 clinical science:primary myelofibrosis: risk stratification by ipss identifies patients with poor clinical outcome by bruno deltreggia benites et al.,

http://www.hindawi.com/journals/ah/2009/179847/ a. etienne, b. gruson, d. chatelain, et al., “myelofibrosis-associated lymphoproliferative disease: retrospective study of 16 cases and literature review,” advances in hematology, vol. 2009, article id 179847, 5 pages, 2009. doi:10.1155/2009/179847

http://www.hindawi.com/journals/crihem/2016/9515404/ ghulam rehman mohyuddin and abdulraheem yacoub, “primary myelofibrosis presenting as extramedullary hematopoiesis in a transplanted liver graft: case report and review of the literature,” case reports in hematology, vol. 2016, article id 9515404, 3 pages, 2016. doi:10.1155/2016/9515404

http://www.hindawi.com/journals/mi/2015/415024/ christophe desterke, christophe martinaud, nadira ruzehaji, and marie-caroline le bousse-kerdilès, “inflammation as a keystone of bone marrow stroma alterations in primary myelofibrosis,” mediators of inflammation, vol. 2015, article id 415024, 16 pages, 2015. doi:10.1155/2015/415024

Myelofibrosis

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