Myelofibrosis, also known as osteomyelofibrosis, is a rare bone marrow cancer. It is currently classified as a myeloproliferative neoplasm, in which the proliferation of an abnormal clone of hematopoietic stem cells in the bone marrow and other sites results infibrosis, or the replacement of the marrow with scar tissue.
The term myelofibrosis alone usually refers to primary myelofibrosis (PMF), also known as chronic idiopathic myelofibrosis(cIMF); the terms idiopathic and primary mean that in these cases the disease is of unknown or spontaneous origin. This is in contrast with myelofibrosis that develops secondary to polycythemia vera or essential thrombocythaemia. Myelofibrosis is a form ofmyeloid metaplasia, which refers to a change in cell type in the blood-forming tissue of the bone marrow, and often the two terms are used synonymously. The terms Agnogenic myeloid metaplasia and myelofibrosis with myeloid metaplasia (MMM) are also used to refer to myelofibrosis.
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http://www.hindawi.com/journals/ah/2015/848473/ keith l. davis, isabelle côté, james a. kaye, estella mendelson, haitao gao, and julian perez ronco, “real-world assessment of clinical outcomes in patients with lower-risk myelofibrosis receiving treatment with ruxolitinib,” advances in hematology, vol. 2015, article id 848473, 9 pages, 2015. doi:10.1155/2015/848473
dewan u, kumari n, jaiswal a, behari s, jain m. extramedullary hemopoiesis with undiagnosed, early myelofibrosis causing spastic compressive myelopathy: case report and review. indian j orthop [serial online] 2010 [cited 2016 jun 29];44:98-103. available from: http://www.ijoonline.com/text.asp?2010/44/1/98/57281
http://www.hindawi.com/journals/crihem/2012/207537/ ayed a. algarni, mojtaba akhtari, and kai fu, “myelodysplastic syndrome with myelofibrosis transformed to a precursor b-cell acute lymphoblastic leukemia: a case report with review of the literature,” case reports in hematology, vol. 2012, article id 207537, 6 pages, 2012. doi:10.1155/2012/207537
http://www.hindawi.com/journals/ah/2009/179847/ a. etienne, b. gruson, d. chatelain, et al., “myelofibrosis-associated lymphoproliferative disease: retrospective study of 16 cases and literature review,” advances in hematology, vol. 2009, article id 179847, 5 pages, 2009. doi:10.1155/2009/179847
http://www.hindawi.com/journals/crihem/2016/9515404/ ghulam rehman mohyuddin and abdulraheem yacoub, “primary myelofibrosis presenting as extramedullary hematopoiesis in a transplanted liver graft: case report and review of the literature,” case reports in hematology, vol. 2016, article id 9515404, 3 pages, 2016. doi:10.1155/2016/9515404
http://www.hindawi.com/journals/mi/2015/415024/ christophe desterke, christophe martinaud, nadira ruzehaji, and marie-caroline le bousse-kerdilès, “inflammation as a keystone of bone marrow stroma alterations in primary myelofibrosis,” mediators of inflammation, vol. 2015, article id 415024, 16 pages, 2015. doi:10.1155/2015/415024