myasthenia-gravis
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Myasthenia Gravis

Myasthenia Gravis

Last Reviewed : 12/24/2020
Myasthenia Gravis

Myasthenia gravis (MG) is a neuromuscular disease that leads to fluctuating muscle weakness and fatigue. In the most common cases, muscle weakness is caused by circulating antibodies that block nicotinic acetylcholine receptorsat the postsynaptic neuromuscular junction. By blocking the ability of the neurotransmitter acetylcholine to bind to these receptors in the muscle, these antibodies keep motor neurons from signaling the muscle to contract. Alternatively, in a much rarer form, muscle weakness is caused by a genetic defect in some portion of the neuromuscular junction that is inherited at birth as opposed to developing through passive transmission from the mother's immune system at birth or through autoimmunity later in life.

Myasthenia is treated with medications such as acetylcholinesterase inhibitors or immunosuppressants, and, in selected cases, thymectomy (surgical removal of the thymus gland).

The disease is diagnosed in 3 to 30 people per million per year. Diagnosis is becoming more common due to increased awareness. The condition occurs more frequently in women than in men and begins most commonly between ages 20 and 40 years of age. The word is from Greek µ?? "muscle", ad??aµ?a "weakness", and Latin: gravis"serious".

We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.

 

Basic information:

http://www.healthline.com/health/myasthenia-gravis health line myasthenia gravis

http://www.mayoclinic.org/diseases-conditions/myasthenia-gravis/home/ovc-20200259 mayoclinic myasthenia gravis

http://www.webmd.com/brain/understanding-myasthenia-gravis-basics web md myasthenia gravis

http://www.nhs.uk/conditions/myasthenia-gravis/pages/introduction.aspx nhs uk myasthenia gravis

https://www.mda.org/disease/myasthenia-gravis mda myasthenia gravis

http://womenshealth.gov/publications/our-publications/fact-sheet/myasthenia-gravis.html womens health myasthenia gravis

https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/myasthenia-gravis better health myasthenia gravis

http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/myasthenia_gravis_85,p07785/ john hopkins health library myasthenia gravis

http://www.merckmanuals.com/professional/neurologic-disorders/peripheral-nervous-system-and-motor-unit-disorders/myasthenia-gravis merck manuals(professional version) myasthenia gravis

http://www.aapos.org/terms/conditions/71 american association of pediatric ophthalmology and strabismus myasthenia gravis

http://my.clevelandclinic.org/services/neurological_institute/neuromuscular-center/diseases-conditions/myasthenia-gravis cleveland clinic myasthenia gravis

https://www.hse.ie/eng/health/az/m/myasthenia-gravis/causes-of-myasthenia-gravis.html health service executive myasthenia gravis

http://lifeinthefastlane.com/ccc/myasthenia-gravis/ life in the fast lane myasthenia gravis

 

Advanced information:

http://emedicine.medscape.com/article/1171206-overview medscape myasthenia gravis

http://www.ninds.nih.gov/disorders/myasthenia_gravis/detail_myasthenia_gravis.htm national institute of neurological disorders and stroke myasthenia gravis

http://www.medicinenet.com/myasthenia_gravis/article.htm medicine net.com myasthenia gravis

http://www.medicalnewstoday.com/articles/179968.php medical news today what is myasthenia gravis? what causes myasthenia gravis?

http://rarediseases.org/rare-diseases/myasthenia-gravis/ national organisation of rare diseases myasthenia gravis

http://patient.info/doctor/myasthenia-gravis-pro patient myasthenia gravis

http://www.news-medical.net/news/20160406/study-explores-two-new-antibodies-believed-to-cause-myasthenia-gravis.aspx news medical net study explores two new antibodies believed to cause myasthenia gravis

http://www.healthcommunities.com/myasthenia-gravis/overview-of-mg.shtml health communities myasthenia gravis

http://neuromuscular.wustl.edu/mtime/mgdx.html myasthenia diagnostic testing

http://eyewiki.aao.org/myasthenia_gravis american academy of ophthalmology myasthenia gravis

http://radiopaedia.org/articles/myasthenia-gravis radiopedia myasthenia gravis

 

Research:

http://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/1471-2474-5-42 myasthenia gravis and pregnancy: clinical implications and neonatal outcome by josé f téllez-zenteno et al., bmc musculoskeletal disordersbmc series ¿ open, inclusive and trusted20045:42 doi: 10.1186/1471-2474-5-42

cherian a, baheti nn, iype t. electrophysiological study in neuromuscular junction disorders. ann indian acad neurol [serial online] 2013 [cited 2016 jun 29];16:34-41. available from: http://www.annalsofian.org/text.asp?2013/16/1/34/107690

cherian a, baheti nn, iype t. electrophysiological study in neuromuscular junction disorders. ann indian acad neurol [serial online] 2013 [cited 2016 jun 29];16:34-41. available from: http://www.annalsofian.org/text.asp?2013/16/1/34/107690

http://www.hindawi.com/journals/ad/2011/847393/ nils erik gilhus, jone f. owe, jana midelfart hoff, fredrik romi, geir olve skeie, and johan a. aarli, “myasthenia gravis: a review of available treatment approaches,” autoimmune diseases, vol. 2011, article id 847393, 6 pages, 2011. doi:10.4061/2011/847393

http://www.hindawi.com/journals/ad/2011/847393/ nils erik gilhus, jone f. owe, jana midelfart hoff, fredrik romi, geir olve skeie, and johan a. aarli, “myasthenia gravis: a review of available treatment approaches,” autoimmune diseases, vol. 2011, article id 847393, 6 pages, 2011. doi:10.4061/2011/847393

http://bmcneurol.biomedcentral.com/articles/10.1186/1471-2377-10-46 a systematic review of population based epidemiological studies in myasthenia gravis by aisling s carr et al., bmc neurologybmc series ¿ open, inclusive and trusted201010:46 doi: 10.1186/1471-2377-10-46

http://www.hindawi.com/journals/criog/2012/736024/ sebastian berlit, benjamin tuschy, saskia spaich, marc sütterlin, and regine schaffelder, “myasthenia gravis in pregnancy: a case report,” case reports in obstetrics and gynecology, vol. 2012, article id 736024, 4 pages, 2012. doi:10.1155/2012/736024

vincent a. autoantibodies in neuromuscular transmission disorders. ann indian acad neurol [serial online] 2008 [cited 2016 jun 29];11:140-5. available from: http://www.annalsofian.org/text.asp?2008/11/3/140/42932

nair ag, patil-chhablani p, venkatramani dv, gandhi ra. ocular myasthenia gravis: a review. indian j ophthalmol [serial online] 2014 [cited 2016 jun 29];62:985-91. available from: http://www.ijo.in/text.asp?2014/62/10/985/145987

chinta s, wallang bs, sachdeva v, gupta a, patil-chhablani p, kekunnaya r. etiology and clinical profile of childhood optic nerve atrophy at a tertiary eye care center in south india. indian j ophthalmol [serial online] 2014 [cited 2016 jun 29];62:1003-7. available from: http://www.ijo.in/text.asp?2014/62/10/1003/145996

http://www.sciencedirect.com/science/article/pii/s2214762414000255 cardiac manifestations of myasthenia gravis: a systematic review by poojita shivamurthy et al., ijc metabolic & endocrine volume 5, november 2014, pages 3–6 doi:10.1016/j.ijcme.2014.08.003

http://www.hindawi.com/journals/ad/2012/874680/ annapurni jayam trouth, alok dabi, noha solieman, mohankumar kurukumbi, and janaki kalyanam, “myasthenia gravis: a review,” autoimmune diseases, vol. 2012, article id 874680, 10 pages, 2012. doi:10.1155/2012/874680

http://www.ojhas.org/issue36/2010-4-16.htm shetty pk, balaiah k, nayak g, shetty pk. thymoma with myasthenia gravis in adolescent. online j health allied scs. 2010;9(4):16

 

Related topics:

https://www.askdrshah.com/myasthenia-gravis.aspx life force homeopathy myasthenia gravis

http://www.myasthenia-gravis-cure.com/cured-cases-of-myasthenia-gravis.html naturopathic medicine myasthenia gravis

 

Other articles:

http://www.vetmed.ucdavis.edu/vsr/neurology/disorders/myasthenia%20gravis.html uc davis veterinary medicine myasthenia gravis

http://www.peteducation.com/article.cfm?c=2+2105&aid=463 pet education myasthenia gravis in puppies

http://vetspecialists.co.uk/factsheets/neurology_facts/myasthenia_gravis.html davis veterinary specialists myasthenia gravis

 

Other helpful resources(support groups):

http://www.myasthenia.org/whatismg.aspx myasthenia gravis foundation of america

http://www.myasthenia-ca.org/ myasthenia gravis foundation of california

http://www.mgnj.org/ myasthenia gravis foundation

http://www.mgakc.org/ myasthenia gravis association

 

Related videos:

https://www.youtube.com/watch?v=bvzzgkgcqrm myasthenia gravis

https://www.youtube.com/watch?v=ftrwaskmhxy what is myasthenia gravis?

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https://www.youtube.com/watch?v=53dsg_ekv4g myasthenia gravis - for nursing students & nurses :)

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https://www.youtube.com/watch?v=svtbrojjdjy neurology - topic 20 - myasthenia gravis and ptosis

https://www.youtube.com/watch?v=qc4uyyo171k myasthenia gravis and exercise

https://www.youtube.com/watch?v=oopyapjmmyq myasthenia gravis, ocular, clinical tests

https://www.youtube.com/watch?v=3qn-vbumdow myasthenia gravis - symptoms and treatment - part 1/2

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