Muscular dystrophy (MD) is a group of muscle diseases that weaken the musculoskeletal system and hamper locomotion (walking or moving ). Muscular dystrophies are characterized by progressive skeletal muscle weakness, defects in muscle proteins, and the death of muscle cells and tissue.
As of 2016, no specific treatment or cure for muscular dystrophy is known. However, physiotherapy, aerobic exercise, low-intensity catabolic steroids such as prednisone, and deflazacort (for which the U.S. FDA has designated fast-track status in January 2016 to conduct clinical trials) can help to maintain muscle tone.
Apart from the nine major types of muscular dystrophy, several MD-like conditions, also known as "outliers", exist. Normal intellectual, behavioral, bowel, and sexual functions are noticed among these "outliers".MD-affected individuals with susceptible intellectual impairment are diagnosed through molecular characteristics, but not through problems associated with disability. However, a third of patients who are severely affected with DMD may have cognitive impairment or behavioral, vision, and speech problems.
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http://dmm.biologists.org/content/7/7/739 zebrafish models in translational research: tipping the scales toward advancements in human health by jennifer b. phillips, monte westerfield disease models and mechanisms 2014 7: 739-743; doi: 10.1242/dmm.015545