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Monoclonal Gammopathy (MGUS)

Monoclonal Gammopathy (MGUS)

Last Reviewed : 12/28/2020
Monoclonal Gammopathy (MGUS)

Monoclonal gammopathy of undetermined significance (MGUS, unknown or uncertain may be substituted forundetermined), formerly benign monoclonal gammopathy, is a condition in which a paraprotein is found in the blood during standard laboratory blood tests. It resembles multiple myeloma and similar diseases, but the levels of antibody are lower, the number of plasma cells (white blood cells that secrete antibodies) in the bone marrow is lower, it has no symptoms or major problems, although patients with MGUS have sometimes been reported to suffer from peripheral neuropathy, and no treatment is indicated. However, multiple myeloma develops at the rate of about 1.5% a year, so doctors recommend monitoring it yearly. The progression from MGUS to multiple myeloma usually involves several steps. In rare cases, it may also be related with a slowly progressive symmetric distal sensorimotor neuropathy.

We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.

 

Basic information:

http://www.mayoclinic.org/diseases-conditions/mgus/home/ovc-20199535 mayoclinic monoclonal gammopathy of undetermined significance (mgus)

https://www.merckmanuals.com/professional/hematology-and-oncology/plasma-cell-disorders/monoclonal-gammopathy-of-undetermined-significance-mgus merck manuals (professional version) monoclonal gammopathy of undetermined significance (mgus) byjames r. berenson, md

 

Advanced information:

http://emedicine.medscape.com/article/204297-overview medscape monoclonal gammopathies of undetermined significance

 

Research:

https://www.hindawi.com/journals/bmri/2015/742762/ antony r. parker, oscar berlanga, and stephen harding, “comment on “clinical comparisons of two free light chain assays to immunofixation electrophoresis for detecting monoclonal gammopathy”,” biomed research international, vol. 2015, article id 742762, 3 pages, 2015. doi:10.1155/2015/742762

thatte ss, dongre am, chikhalkar sb, khopkar us. papular mucinosis associated with monoclonal gammopathy of unknown significance. indian j dermatol venereol leprol [serial online] 2015 [cited 2016 sep 25];81:213-4. available from: http://www.ijdvl.com/text.asp?2015/81/2/213/152308

kocak m, keles h, yakaryilmaz f, bozdogan o, guliter s. diffuse plane xanthomatosis in a patient with budd-chiari syndrome and monoclonal gammopathy. indian j dermatol [serial online] 2009 [cited 2016 sep 25];54:369-71. available from: http://www.e-ijd.org/text.asp?2009/54/4/369/57616

kocabeyoglu s, mocan mc, haznedaroglu ic, uner a, uzunosmanoglu e, irkec m. in vivo confocal microscopic characteristics of crystalline keratopathy in patients with monoclonal gammopathy: report of two cases . indian j ophthalmol [serial online] 2014 [cited 2016 sep 25];62:938-40. available from: http://www.ijo.in/text.asp?2014/62/9/938/143933

https://www.hindawi.com/journals/bmri/2014/647238/ han-sung kim, hyun soo kim, kyu-sung shin, et al., “clinical comparisons of two free light chain assays to immunofixation electrophoresis for detecting monoclonal gammopathy,” biomed research international, vol. 2014, article id 647238, 7 pages, 2014. doi:10.1155/2014/647238

http://www.scielo.br/scielo.php?script=sci_arttext&pid=s0365-05962011000700012 an. bras. dermatol. vol.86 no.4 supl.1 rio de janeiro july/aug. 2011 http://dx.doi.org/10.1590/s0365-05962011000700012 case report:diffuse plane xanthomatosis associated with monoclonal gammopathy by aristóteles rosmaninho et al.,

https://www.hindawi.com/journals/crim/2010/406102/ francois abi-fadel, nisarg r. desai, gita vatandoust, rabih said, aaron gottesman, and terenig terjanian, “monoclonal gammopathy of undetermined significance with amyloid deposition in the lung and non-amyloid eosinophilic deposition in the brain: a case report,” case reports in medicine, vol. 2010, article id 406102, 4 pages, 2010. doi:10.1155/2010/406102

http://europepmc.org/backend/ptpmcrender.fcgi?accid=pmc4368597&blobtype=pdf : barceló f, cerdà jj, gutiérrez a, jimenezmarco t, durán ma, novo a, et al. (2015) characterization of monoclonal gammopathy of undetermined significance by calorimetric analysis of blood serum proteome. plos one 10(3):e0120316. doi:10.1371/journal.pone.0120316

https://www.hindawi.com/journals/crim/2015/953297/ riad akoum, wassim serhal, and hussein farhat, “disseminated gastric malt lymphoma with monoclonal gammopathy, t(11;18)(q21;q21), and subsequent development of t-large granular lymphocytic leukemia: a case report and review of the literature,” case reports in medicine, vol. 2015, article id 953297, 9 pages, 2015. doi:10.1155/2015/953297

https://www.hindawi.com/journals/crim/2012/607104/ dimitrios stoimenis, christina spyridonidou, and nikos papaioannou, “transient monoclonal gammopathy induced by disseminated staphylococcus aureus infection,” case reports in medicine, vol. 2012, article id 607104, 5 pages, 2012. doi:10.1155/2012/607104

https://www.hindawi.com/journals/crig/2011/143132/ tanjung a. sumekar, aneel a. ashrani, tri i. winarni, and randi j. hagerman, “monoclonal gammopathy of undetermined significance (mgus) in a man with fragile x-associated tremor/ataxia syndrome,” case reports in genetics, vol. 2011, article id 143132, 5 pages, 2011. doi:10.1155/2011/143132

patnala gp, sunandini ap, rayavarapu r, yandapalli ps. erythema elevatum diutinum in association with iga monoclonal gammopathy: a rare case report. indian dermatol online j [serial online] 2016 [cited 2016 sep 25];7:300-3. available from: http://www.idoj.in/text.asp?2016/7/4/300/185472

https://www.hindawi.com/journals/crin/2012/573650/ yijuan sun, amarpreet sandhu, darlene gabaldon, jonathan danaraj, karen s. servilla, and antonios h. tzamaloukas, “development of renal failure without proteinuria in a patient with monoclonal gammopathy of undetermined significance: an unusual presentation of al kappa amyloidosis,” case reports in nephrology, vol. 2012, article id 573650, 5 pages, 2012. doi:10.1155/2012/573650

https://www.ncbi.nlm.nih.gov/pmc/articles/pmc2719521/ disease associations with monoclonal gammopathy of undetermined significance: a population-based study of 17,398 patients by john p. bida, ma et al., mayo clin proc. 2009 aug; 84(8): 685–693. pmcid: pmc2719521

http://www.haematologica.org/content/99/6/984 the clinical relevance and management of monoclonal gammopathy of undetermined significance and related disorders: recommendations from the european myeloma network by niels w.c.j. van de donk et al., haematologica june 2014 99: 984-996; doi:10.3324/haematol.2013.100552

http://www.nejm.org/doi/full/10.1056/nejmoa01133202#t=article a long-term study of prognosis in monoclonal gammopathy of undetermined significance by robert a. kyle, m.d., n engl j med 2002; 346:564-569february 21, 2002doi: 10.1056/nejmoa01133202

 

Related videos:

https://www.khanacademy.org/science/health-and-medicine/hematologic-system-diseases-2/plasma-cell-dyscrasias/v/what-is-monoclonal-gammopathy-of-undetermined-significance-mgus what is monoclonal gammopathy of undetermined significance (mgus)?

https://www.youtube.com/watch?v=k25n7zfsao0 what is monoclonal gammopathy of undetermined significance (mgus)?

https://www.youtube.com/watch?v=63x2buctu10 mgus and smoldering myeloma

https://www.youtube.com/watch?v=4uogrwbbyp0 monoclonal gammopathy of uncertain significance neuropathy | dr. martin rutherford | dr. randall ...

https://www.youtube.com/watch?v=iocq3oljaxi new diagnostics and therapeutics for the management of patients with monoclonal gammopathies

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