Monoclonal gammopathy of undetermined significance (MGUS, unknown or uncertain may be substituted forundetermined), formerly benign monoclonal gammopathy, is a condition in which a paraprotein is found in the blood during standard laboratory blood tests. It resembles multiple myeloma and similar diseases, but the levels of antibody are lower, the number of plasma cells (white blood cells that secrete antibodies) in the bone marrow is lower, it has no symptoms or major problems, although patients with MGUS have sometimes been reported to suffer from peripheral neuropathy, and no treatment is indicated. However, multiple myeloma develops at the rate of about 1.5% a year, so doctors recommend monitoring it yearly. The progression from MGUS to multiple myeloma usually involves several steps. In rare cases, it may also be related with a slowly progressive symmetric distal sensorimotor neuropathy.
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https://www.hindawi.com/journals/bmri/2015/742762/ antony r. parker, oscar berlanga, and stephen harding, “comment on “clinical comparisons of two free light chain assays to immunofixation electrophoresis for detecting monoclonal gammopathy”,” biomed research international, vol. 2015, article id 742762, 3 pages, 2015. doi:10.1155/2015/742762
thatte ss, dongre am, chikhalkar sb, khopkar us. papular mucinosis associated with monoclonal gammopathy of unknown significance. indian j dermatol venereol leprol [serial online] 2015 [cited 2016 sep 25];81:213-4. available from: http://www.ijdvl.com/text.asp?2015/81/2/213/152308
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https://www.hindawi.com/journals/bmri/2014/647238/ han-sung kim, hyun soo kim, kyu-sung shin, et al., “clinical comparisons of two free light chain assays to immunofixation electrophoresis for detecting monoclonal gammopathy,” biomed research international, vol. 2014, article id 647238, 7 pages, 2014. doi:10.1155/2014/647238
https://www.hindawi.com/journals/crim/2010/406102/ francois abi-fadel, nisarg r. desai, gita vatandoust, rabih said, aaron gottesman, and terenig terjanian, “monoclonal gammopathy of undetermined significance with amyloid deposition in the lung and non-amyloid eosinophilic deposition in the brain: a case report,” case reports in medicine, vol. 2010, article id 406102, 4 pages, 2010. doi:10.1155/2010/406102
https://www.hindawi.com/journals/crim/2015/953297/ riad akoum, wassim serhal, and hussein farhat, “disseminated gastric malt lymphoma with monoclonal gammopathy, t(11;18)(q21;q21), and subsequent development of t-large granular lymphocytic leukemia: a case report and review of the literature,” case reports in medicine, vol. 2015, article id 953297, 9 pages, 2015. doi:10.1155/2015/953297
https://www.hindawi.com/journals/crim/2012/607104/ dimitrios stoimenis, christina spyridonidou, and nikos papaioannou, “transient monoclonal gammopathy induced by disseminated staphylococcus aureus infection,” case reports in medicine, vol. 2012, article id 607104, 5 pages, 2012. doi:10.1155/2012/607104
https://www.hindawi.com/journals/crig/2011/143132/ tanjung a. sumekar, aneel a. ashrani, tri i. winarni, and randi j. hagerman, “monoclonal gammopathy of undetermined significance (mgus) in a man with fragile x-associated tremor/ataxia syndrome,” case reports in genetics, vol. 2011, article id 143132, 5 pages, 2011. doi:10.1155/2011/143132
patnala gp, sunandini ap, rayavarapu r, yandapalli ps. erythema elevatum diutinum in association with iga monoclonal gammopathy: a rare case report. indian dermatol online j [serial online] 2016 [cited 2016 sep 25];7:300-3. available from: http://www.idoj.in/text.asp?2016/7/4/300/185472
https://www.hindawi.com/journals/crin/2012/573650/ yijuan sun, amarpreet sandhu, darlene gabaldon, jonathan danaraj, karen s. servilla, and antonios h. tzamaloukas, “development of renal failure without proteinuria in a patient with monoclonal gammopathy of undetermined significance: an unusual presentation of al kappa amyloidosis,” case reports in nephrology, vol. 2012, article id 573650, 5 pages, 2012. doi:10.1155/2012/573650
http://www.haematologica.org/content/99/6/984 the clinical relevance and management of monoclonal gammopathy of undetermined significance and related disorders: recommendations from the european myeloma network by niels w.c.j. van de donk et al., haematologica june 2014 99: 984-996; doi:10.3324/haematol.2013.100552