Monoclonal Gammopathy (MGUS)

Monoclonal Gammopathy (MGUS)

Last Reviewed : 12/28/2020
Monoclonal Gammopathy (MGUS)

Monoclonal gammopathy of undetermined significance (MGUS, unknown or uncertain may be substituted forundetermined), formerly benign monoclonal gammopathy, is a condition in which a paraprotein is found in the blood during standard laboratory blood tests. It resembles multiple myeloma and similar diseases, but the levels of antibody are lower, the number of plasma cells (white blood cells that secrete antibodies) in the bone marrow is lower, it has no symptoms or major problems, although patients with MGUS have sometimes been reported to suffer from peripheral neuropathy, and no treatment is indicated. However, multiple myeloma develops at the rate of about 1.5% a year, so doctors recommend monitoring it yearly. The progression from MGUS to multiple myeloma usually involves several steps. In rare cases, it may also be related with a slowly progressive symmetric distal sensorimotor neuropathy.

We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.


Basic information: mayoclinic monoclonal gammopathy of undetermined significance (mgus) merck manuals (professional version) monoclonal gammopathy of undetermined significance (mgus) byjames r. berenson, md


Advanced information: medscape monoclonal gammopathies of undetermined significance


Research: antony r. parker, oscar berlanga, and stephen harding, “comment on “clinical comparisons of two free light chain assays to immunofixation electrophoresis for detecting monoclonal gammopathy”,” biomed research international, vol. 2015, article id 742762, 3 pages, 2015. doi:10.1155/2015/742762

thatte ss, dongre am, chikhalkar sb, khopkar us. papular mucinosis associated with monoclonal gammopathy of unknown significance. indian j dermatol venereol leprol [serial online] 2015 [cited 2016 sep 25];81:213-4. available from:

kocak m, keles h, yakaryilmaz f, bozdogan o, guliter s. diffuse plane xanthomatosis in a patient with budd-chiari syndrome and monoclonal gammopathy. indian j dermatol [serial online] 2009 [cited 2016 sep 25];54:369-71. available from:

kocabeyoglu s, mocan mc, haznedaroglu ic, uner a, uzunosmanoglu e, irkec m. in vivo confocal microscopic characteristics of crystalline keratopathy in patients with monoclonal gammopathy: report of two cases . indian j ophthalmol [serial online] 2014 [cited 2016 sep 25];62:938-40. available from: han-sung kim, hyun soo kim, kyu-sung shin, et al., “clinical comparisons of two free light chain assays to immunofixation electrophoresis for detecting monoclonal gammopathy,” biomed research international, vol. 2014, article id 647238, 7 pages, 2014. doi:10.1155/2014/647238 an. bras. dermatol. vol.86 no.4 supl.1 rio de janeiro july/aug. 2011 case report:diffuse plane xanthomatosis associated with monoclonal gammopathy by aristóteles rosmaninho et al., francois abi-fadel, nisarg r. desai, gita vatandoust, rabih said, aaron gottesman, and terenig terjanian, “monoclonal gammopathy of undetermined significance with amyloid deposition in the lung and non-amyloid eosinophilic deposition in the brain: a case report,” case reports in medicine, vol. 2010, article id 406102, 4 pages, 2010. doi:10.1155/2010/406102 : barceló f, cerdà jj, gutiérrez a, jimenezmarco t, durán ma, novo a, et al. (2015) characterization of monoclonal gammopathy of undetermined significance by calorimetric analysis of blood serum proteome. plos one 10(3):e0120316. doi:10.1371/journal.pone.0120316 riad akoum, wassim serhal, and hussein farhat, “disseminated gastric malt lymphoma with monoclonal gammopathy, t(11;18)(q21;q21), and subsequent development of t-large granular lymphocytic leukemia: a case report and review of the literature,” case reports in medicine, vol. 2015, article id 953297, 9 pages, 2015. doi:10.1155/2015/953297 dimitrios stoimenis, christina spyridonidou, and nikos papaioannou, “transient monoclonal gammopathy induced by disseminated staphylococcus aureus infection,” case reports in medicine, vol. 2012, article id 607104, 5 pages, 2012. doi:10.1155/2012/607104 tanjung a. sumekar, aneel a. ashrani, tri i. winarni, and randi j. hagerman, “monoclonal gammopathy of undetermined significance (mgus) in a man with fragile x-associated tremor/ataxia syndrome,” case reports in genetics, vol. 2011, article id 143132, 5 pages, 2011. doi:10.1155/2011/143132

patnala gp, sunandini ap, rayavarapu r, yandapalli ps. erythema elevatum diutinum in association with iga monoclonal gammopathy: a rare case report. indian dermatol online j [serial online] 2016 [cited 2016 sep 25];7:300-3. available from: yijuan sun, amarpreet sandhu, darlene gabaldon, jonathan danaraj, karen s. servilla, and antonios h. tzamaloukas, “development of renal failure without proteinuria in a patient with monoclonal gammopathy of undetermined significance: an unusual presentation of al kappa amyloidosis,” case reports in nephrology, vol. 2012, article id 573650, 5 pages, 2012. doi:10.1155/2012/573650 disease associations with monoclonal gammopathy of undetermined significance: a population-based study of 17,398 patients by john p. bida, ma et al., mayo clin proc. 2009 aug; 84(8): 685–693. pmcid: pmc2719521 the clinical relevance and management of monoclonal gammopathy of undetermined significance and related disorders: recommendations from the european myeloma network by niels w.c.j. van de donk et al., haematologica june 2014 99: 984-996; doi:10.3324/haematol.2013.100552 a long-term study of prognosis in monoclonal gammopathy of undetermined significance by robert a. kyle, m.d., n engl j med 2002; 346:564-569february 21, 2002doi: 10.1056/nejmoa01133202


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