Lewy body Dementia

Dementia with Lewy bodies (DLB) is a type of dementia that gradually worsens over time. Additional symptoms may include fluctuations in alertness, seeing things that other people do not, slowness of movement, trouble walking, and rigidity. Excessive movement during sleep and mood changes such as depression are also common.

The cause is unknown. There is typically no family history among those affected. The underlying mechanism involves the buildup of Lewy bodies, clumps of alpha-synuclein protein in neurons. It is classified as a neurodegenerative disorder. A diagnosis may be suspected based on symptom, with blood tests and medical imaging done to rule out other possible causes.^[4] The differential diagnosis includes Parkinson's and Alzheimer's.

There is no cure for DLB. Treatments try to improve mental, psychiatric, and motor symptoms. Acetylcholinesterase inhibitors, such as donepezil, may provide some benefit. Some motor problems may improve with levodopa. Antipsychotics, even for hallucination, should generally be avoided due to side effects.

DLB is the most common cause of dementia after Alzheimer's and vascular dementia. It typically begins after the age of 50. About 0.1% of those over 65 are affected. Males appear to be more commonly affected than females. In the late part of the disease people may depend entirely on others for their care. Life expectancy following diagnosis is around 8 years. The abnormal deposits that cause the disease were discovered in 1912 by Frederic Lewy.

We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.

Basic information:

http://www.mayoclinic.org/diseases-conditions/lewy-body-dementia/home/ovc-20200344 mayo clinic lewy body dementia

https://www.alzheimers.org.uk/site/scripts/documents_info.php?documentid=113 alzheimers society lewy body dementia

https://www.nia.nih.gov/alzheimers/publication/lewy-body-dementia/introduction national institute on aging lewy body dementia

http://www.helpguide.org/articles/alzheimers-dementia/lewy-body-dementia.htm help guide lewy body dementia

http://www.nhs.uk/conditions/dementia-with-lewy-bodies/pages/introduction.aspx nhs uk dementia with lewy bodies

http://www.webmd.com/alzheimers/guide/dementia-lewy-bodies web md what is lewy body dementia?

http://www.merckmanuals.com/professional/neurologic-disorders/delirium-and-dementia/lewy-body-dementia-and-parkinson-disease-dementia merck manuals (professional version) lewy body dementia and parkinson disease dementia

http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/dementia_with_lewy_bodies_134,76/ john hopkins medical library dementia with lewy bodies (dlb)

https://www.verywell.com/symptoms-of-lewy-body-dementia-98764 very well do you know these less common symptoms of lewy body dementia?

http://www.livestrong.com/article/239353-final-stages-of-lewy-body-dementia/ live strong final stages of lewy body dementia

Advanced information:

http://www.medicalnewstoday.com/articles/302230.php medical news today lewy body dementia: unrecognized and misdiagnosed

http://emedicine.medscape.com/article/1135041-overview medscape dementia with lewy bodies

http://www.medicinenet.com/lewy_body_dementia_lbd_symptoms_and_prognosis/views.htm medicine net lewy body dementia symptoms and prognosis

http://patient.info/in/doctor/dementia-with-lewy-bodies patient dementia with lewy bodies

http://www.emedicinehealth.com/dementia_with_lewy_bodies/article_em.htm emedicine health dementia with lewy bodies

https://radiopaedia.org/articles/dementia-with-lewy-bodies radiopedia dementia with lewy bodies

http://www.aafp.org/afp/2006/0401/p1223.html dementia with lewy bodies: an emerging disease doug neef, m.d., via christi family medicine residency, wichita, kansas anne d. walling, m.b., ch.b., university of kansas school of medicine,–wichita, wichita, kansas am fam physician. 2006 apr 1;73(7):1223-1229.

Research:

http://journal.frontiersin.org/article/10.3389/fnhum.2014.00726/full original research article front. hum. neurosci., 24 september 2014 | http://dx.doi.org/10.3389/fnhum.2014.00726 nature and extent of person recognition impairments associated with capgras syndrome in lewy body dementia by chris m. fiacconi et al.,

http://europepmc.org/backend/ptpmcrender.fcgi?accid=pmc2982819&blobtype=pdf price dl, rockenstein e, ubhi k, phung v, maclean-lewis n, et al. (2010) alterations in mglur5 expression and signaling in lewy body disease and in transgenic models of alpha-synucleinopathy – implications for excitotoxicity. plos one 5(11): e14020. doi:10.1371/journal.pone.0014020

http://europepmc.org/backend/ptpmcrender.fcgi?accid=pmc4892610&blobtype=pdf inskip m, mavros y, sachdev ps, fiatarone singh ma (2016) exercise for individuals with lewy body dementia: a systematic review. plos one 11(6): e0156520. doi:10.1371/journal.pone.0156520

http://europepmc.org/backend/ptpmcrender.fcgi?accid=pmc3485000&blobtype=pdf : maetzler w, tian y, baur sm, gauger t, odoj b, et al. (2012) serum and cerebrospinal fluid levels of transthyretin in lewy body disorders with and without dementia. plos one 7(10): e48042. doi:10.1371/journal.pone.0048042

http://molecularneurodegeneration.biomedcentral.com/articles/10.1186/1750-1326-1-17 lrrk2 in parkinson's disease and dementia with lewy bodies by xiongwei zhu et al., molecular neurodegeneration20061:17 doi: 10.1186/1750-1326-1-17

http://www.scielo.br/scielo.php?script=sci_arttext&pid=s0047-20852013000200007&lng=en&tlng=en j. bras. psiquiatr. vol.62 no.2 rio de janeiro apr./june 2013 http://dx.doi.org/10.1590/s0047-20852013000200007 original article clinical diagnosis of 80 cases of dementia in a university hospital by renata teles vieira et al.,

http://europepmc.org/backend/ptpmcrender.fcgi?accid=pmc3798383&blobtype=pdf tola-arribas ma, yugueros mi, garea mj, ortega-valín f, cerón-fernández a, et al. (2013) prevalence of dementia and subtypes in valladolid, northwestern spain: the deminvall study. plos one 8(10): e77688. doi:10.1371/journal.pone.0077688

http://www.scielo.br/scielo.php?script=sci_arttext&pid=s0004-282x2003000600009 arq. neuro-psiquiatr. vol.61 no.4 são paulo dec. 2003 http://dx.doi.org/10.1590/s0004-282x2003000600009 nightmares without atonia as an early symptom of diffuse lewy bodies disease by paulo roberto de brito-marques et al.,

http://molecularneurodegeneration.biomedcentral.com/articles/10.1186/1750-1326-4-32 ectopic localization of foxo3a protein in lewy bodies in lewy body dementia and parkinson's disease by bo su et al., molecular neurodegeneration20094:32 doi: 10.1186/1750-1326-4-32

http://journal.frontiersin.org/article/10.3389/fnins.2015.00293/full mini review article front. neurosci., 20 august 2015 | http://dx.doi.org/10.3389/fnins.2015.00293 disease-modifying therapeutic directions for lewy-body dementias by qiang zhang et al.,

http://journal.frontiersin.org/article/10.3389/fneur.2013.00151/full opinion article front. neurol., 07 october 2013 | http://dx.doi.org/10.3389/fneur.2013.00151 neuroimaging, biomarkers, and management of dementia with lewy bodies by hasmet a. hanagasi et al.,

http://translationalneurodegeneration.biomedcentral.com/articles/10.1186/2047-9158-2-4 can we clinically diagnose dementia with lewy bodies yet? yue huang and glenda halliday et al., translational neurodegeneration20132:4 doi: 10.1186/2047-9158-2-4

http://europepmc.org/backend/ptpmcrender.fcgi?accid=pmc4777571&blobtype=pdf : maetzler w, deleersnijder w, hanssens v,bernard a, brockmann k, marquetand j, et al. (2016)gdf15/mic1 and mmp9 cerebrospinal fluid levels in parkinson’s disease and lewy body dementia. plos one 11(3): e0149349. doi:10.1371/journal.pone.0149349

Other helpful resources(support groups):

https://www.lbda.org/category/3437/what-is-lbd.htm lewy body dementia association

http://www.lewybody.org/ the lewy body society

Related videos:

https://www.youtube.com/watch?v=cihtiy_68ji the science of lewy body dementia

https://www.youtube.com/watch?v=me_kdkycdie understanding behavioral challenges in lewy body dementia

https://www.youtube.com/watch?v=hvd9dhlk6fc understanding lewy-body dementia

https://www.youtube.com/watch?v=bilwpwqb3my report: robin williams had lewy body dementia

Presentations/quiz/newspaper articles:

https://www.scientificamerican.com/article/howlewy-body-dementia-gripped-robin-williams1/ scientific american how lewy body dementia gripped robin williams

http://www.huffingtonpost.in/entry/robin-williams-dementia-with-lewy-bodies_us_5638f32ee4b027f9b96a418f huffington post what you should know about robin williams' lewy body dementia

http://time.com/4098222/lewy-body-dementia-robin-williams/time here’s what to know about lewy body dementia

http://www.nextavenue.org/why-we-missed-the-signs-of-my-moms-lewy-body-dementia/ next avenue why we missed the signs of my mom’s lewy body dementia

https://www.washingtonpost.com/news/morning-mix/wp/2015/11/04/lewy-body-dementia-the-devastating-disease-that-robin-williamss-widow-blames-for-his-death/ washingtons post lewy body dementia, the devastating disease that robin williams’s widow blames for his death

http://www.cbsnews.com/news/what-is-lewy-body-dementia/ cbs news what is lewy body dementia?

https://www.theguardian.com/society/2015/nov/17/dementia-lewy-bodies-disease-kathleen-anduze-robin-williams the guardian losing her mind and watching it go: the slow suffering of lewy body disease

http://www.independent.co.uk/life-style/health-and-families/features/lewy-body-dementia-what-is-the-condition-which-robin-williams-wife-blames-for-his-death-a6720931.html independant lewy body dementia: what is the condition which robin williams' wife blames for his death?

http://theconversation.com/robin-williams-had-dementia-with-lewy-bodies-so-what-is-it-and-why-has-it-been-eclipsed-by-alzheimers-50221 the conversation robin williams had dementia with lewy bodies – so, what is it and why has it been eclipsed by alzheimer’s?

http://www.telegraph.co.uk/wellbeing/health-advice/lewy-body-dementia-the-disease-that-killed-robin-williams/ the telegraph lewy body dementia: the disease that killed robin williams