Large B Cell lymphoma

Large B Cell lymphoma

Last Reviewed : 12/28/2020
Large B Cell lymphoma

Diffuse large B-cell lymphoma (DLBCL or DLBL) is a cancer of B cells, a type of white blood cell responsible for producingantibodies. It is the most common type of non-Hodgkin lymphoma among adults, with an annual incidence of 7–8 cases per 100,000 people per year. This cancer occurs primarily in older individuals, with a median age of diagnosis at approximately 70 years of age, though it can also occur in children and young adults in rare cases. DLBCL is an aggressive tumor which can arise in virtually any part of the body, and the first sign of this illness is typically the observation of a rapidly growing mass, sometimes associated with fever, weight loss, and night sweats.

The causes of diffuse large B-cell lymphoma are not well understood. Usually DLBCL arises from normal B cells, but it can also represent a malignant transformation of other types of lymphoma or leukemia. An underlying immunodeficiency is a significant risk factor. Infection with Epstein–Barr virus has also been found to contribute to the development of some subgroups of DLBCL.

Diagnosis of DLBCL is made by removing a portion of the tumor through a biopsy, and then examining this tissue using a microscope. Usually a hematopathologist makes this diagnosis. Several subtypes of DLBCL have been identified, each having a different clinical presentation and prognosis. However, the usual treatment for each of these is chemotherapy, often in combination with an antibody targeted at the tumor cells. Through these treatments, more than half of patients with DLBCL can be cured, and the overall five-year survival rate for older adults is around 58%.

We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.




Basic information: diffuse large b-cell lymphoma (dlbcl) lymphoma research foundation diffuse large b-cell lymphoma lymphoma association diffuse large b-cell lymphoma leukemia foundation diffuse large b-cell lymphoma web md diffuse large b-cell lymphoma mayo clinic definition


Advanced information: medscape diffuse large cell lymphoma upto date diffuse large b cell lymphoma overview guidelines for the management of diffuse large b-cell lymphoma by sridhar chaganti (writing group chair) et al., pathology outlines lymphoma - b cell neoplasms b cell lymphoma subtypes diffuse large b cell lymphoma (dlbcl) american college of radiology acr appropriateness criteria® diffuse large b-cell lymphoma by expert panel on radiation oncology–lymphoma: bouthaina s. dabaja, md et al., dako diffuse large b-cell lymphoma dermnet nz cutaneous b-cell lymphoma dove med primary mediastinal large b-cell lymphoma


Research: how i treat patients with diffuse large b-cell lymphoma by james o. armitage blood 2007 110:29-36; doi:10.1182/blood-2007-01-041871 diffuse large b-cell lymphoma: esmo clinical practice guidelines ann oncol (2015) 26 (suppl 5): v116-v125 by h. tilly, m. gomes da silva, u. vitolo, a. jack, m. meignan, a. lopez-guillermo, j. walewski, m. andré, p. w. johnson, m. pfreundschuh, m. ladetto

mondal sk, mandal pk, roy s, biswas pk. primary cutaneous large b-cell lymphoma, leg type: report of two cases and review of literature. indian j med paediatr oncol [serial online] 2012 [cited 2016 jun 14];33:54-7. available from:

corti m, bistmans a, narbaitz m. primary parotid b-cell lymphoma successfully treated with chemotherapy plus highly active antiretroviral therapy with prolonged survival and immune reconstitution in an acquired immunodeficiency syndrome patient: case report and review of the literature. clin cancer investig j [serial online] 2014 [cited 2016 jun 14];3:401-4. available from:

roh sy, lee jy, park kw, jung sn. sparganosis in a patient with diffuse large b cell lymphoma. j can res ther [serial online] 2013 [cited 2016 jun 14];9:712-4. available from:

daneshbod y, omidvari s, daneshbod k, negahban s, dehghani m. diffuse large b cell lymphoma of thyroid as a masquerader of anaplastic carcinoma of thyroid, diagnosed by fna : a case report. cytojournal [serial online] 2006 [cited 2016 jun 14];3:23. available from:

vasudevan ja, nair ra, nair sg, prahlada a. primary diffuse large b-cell lymphoma of the central nervous system in pineal gland: report of a rare case with review of literature. indian j pathol microbiol [serial online] 2015 [cited 2016 jun 14];58:412-3. available from:

iqbal j, joshi s, patel kn, javed si, kucuk c, aabida a, d'amore f, fu k. clinical implication of genome-wide profiling in diffuse large b-cell lymphoma and other subtypes of b-cell lymphoma. indian j cancer [serial online] 2007 [cited 2016 jun 14];44:72-86. available from: secondary cutaneous epstein-barr virus-associated diffuse large b-cell lymphoma in a patient with angioimmunoblastic t-cell lymphoma: a case report and review of literature by qing-xu yang et al., insights into the molecular pathogenesis of activated b-cell-like diffuse large b-cell lymphoma and its therapeutic implications by georg lenz . cancers 2015, 7(2), 811-822; doi:10.3390/cancers7020812 inhibition of the pi3k/akt/mtor signaling pathway in diffuse large b-cell lymphoma: current knowledge and clinical significance by agata majchrzak et al., molecules 2014, 19(9), 14304-14315; doi:10.3390/molecules190914304 primary intravascular large b-cell lymphoma of lung: a report of one case and review by hui yu et al., diagnostic pathology20127:70 doi: 10.1186/1746-1596-7-70,%20vol%202,%20no%201,%20jan%20-%20june%202013,%20109-116.pdf case report:primary diffuse large b-cell lymphoma of the uterus manifesting as a leiomyoma: a unique presentation with review of literature by sergei tatishchev et al., jkimsu, vol. 2, no. 1, jan-june 2013


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