Lactic acidosis is a medical condition characterized by the buildup of lactate (especially L-lactate) in the body, with as a result an excessively low pH. It is a subtype of metabolic acidosis, where excessive acid is due to a problem with the body'smetabolism.
Lactic acidosis is typically the result of an underlying acute or chronic medical condition, medication, or poisoning. The symptoms are generally attributable to these underlying causes, but may include nausea, vomiting, rapid deep breathing, and generalised weakness.
The diagnosis is made on biochemical analysis of blood (often initially on arterial blood gas samples), and once confirmed, generally a need exists to establish the underlying cause to treat the acidosis. In some situations, hemofiltration (purification of the blood) is temporarily required. In rare chronic forms of lactic acidosis caused by mitochondrial disease, a specific diet ordichloroacetate may be used. The prognosis of lactic acidosis depends largely on the underlying cause; in some situations (such as severe infections), it indicates an increased risk of death.
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https://www.hindawi.com/journals/crim/2009/534561/ farn huei chan, daniel carl, and laurel j. lyckholm, “severe lactic acidosis in a patient with b-cell lymphoma: a case report and review of the literature,” case reports in medicine, vol. 2009, article id 534561, 6 pages, 2009. doi:10.1155/2009/534561
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