Kawasaki disease

Kawasaki disease

Last Reviewed : 12/28/2020
Kawasaki disease

Kawasaki disease is a disease in which blood vessels throughout the body become inflamed. The most common symptoms include a fever that lasts for more than five days and is not controlled by usual medications, large lymph nodes in the neck, a rash in the genital area, and red eyes, lips, palms or bottoms of the feet. Other symptoms include sore throat and diarrhea. Within three weeks of the onset of symptoms the skin from the hands and feet may peel. Recovery then typically occurs. In some children, coronary artery aneurysms may form in the heart.

The cause is unknown. It may be due to an infection triggering an autoimmune response in those who are genetically predisposed. It is not spread between people. Diagnosis is usually based on a person's signs and symptoms. Other tests such as an ultrasound of the heart and blood tests may support the diagnosis. Other conditions that may present similarly include scarlet fever and juvenile rheumatoid arthritis.

Initially treatment is typically with high doses of aspirin and immunoglobulin. Usually with treatment fever resolves within 24 hours and there is a full recovery. If the coronary arteries are involved ongoing treatment or surgery may occasionally be required. Without treatment coronary artery problems occur in up to 25% and about 1% die. With treatment the risk of death is 0.17%.

Kawasaki disease is rare. It affects between 8 and 67 per 100,000 people under the age of five except in Japan where it affects 124 per 100,000. It is much less common after the age of five. Boys are more commonly affected than girls. The disorder was first described in 1967 by Tomisaku Kawasaki in Japan.

We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.




Basic information:

http://www.webmd.com/children/tc/kawasaki-disease-topic-overview#1 web md kawasaki disease - topic overview

http://kidshealth.org/en/parents/kawasaki.html kidshealth kawasaki disease

http://www.healthline.com/health/kawasaki-disease health line what is kawasaki disease?

http://www.nhs.uk/conditions/kawasaki-disease/pages/introduction.aspx nhs uk kawasaki disease

http://www.mayoclinic.org/diseases-conditions/kawasaki-disease/home/ovc-20259782 mayoclinic kawasaki disease

https://www.nhlbi.nih.gov/health/health-topics/topics/kd national heart lung blood institute kawasaki disease

https://www.healthychildren.org/english/health-issues/conditions/heart/pages/kawasaki-disease.aspx healthy children kawasaki disease

https://familydoctor.org/condition/kawasaki-disease/ family doctr kawasaki disease

http://www.aboutkidshealth.ca/en/healthaz/conditionsanddiseases/inflammatoryconditions/pages/kawasaki-disease.aspx about kids health kawasaki disease

https://www.healthlinkbc.ca/health-topics/hw180460 health link bc kawasaki disease

http://my.clevelandclinic.org/childrens-hospital/health-info/diseases-conditions/kawasaki-disease cleveland clinic kawasaki disease

http://www.merckmanuals.com/professional/pediatrics/miscellaneous-disorders-in-infants-and-children/kawasaki-disease-kd merck manuals kawasaki disease

http://umm.edu/health/medical/ency/articles/kawasaki-disease university of maryland medical center kawasaki disease

https://www.verywell.com/kawasaki-disease-2634098 very well kawasaki disease


Advanced information:

http://emedicine.medscape.com/article/965367-overview medcsape kawasaki disease

http://www.heart.org/heartorg/conditions/more/cardiovascularconditionsofchildhood/kawasaki-disease-complications-treatment-and-prevention_ucm_311584_article.jsp#.wguzpnkufp0 american heart association kawasaki disease: complications, treatment and prevention

http://www.medicinenet.com/kawasaki_disease/article.htm medicine net kawasaki disease

http://www.medicalnewstoday.com/articles/164533.php medical news today what is kawasaki disease? what causes kawasaki disease?

http://patient.info/in/health/kawasaki-disease-leaflet patient kawasaki disease

https://medlineplus.gov/kawasakidisease.html medline plus kawasaki disease

https://rarediseases.org/rare-diseases/kawasaki-disease/ national organisation for rare diseases kawasaki disease

http://www.aafp.org/afp/1999/0601/p3093.html kawasaki disease kathryn a. taubert, ph.d., university of texas southwestern medical school, dallas, texas stanford t. shulman, m.d., northwestern university medical school, chicago, illinois am fam physician. 1999 jun 1;59(11):3093-3102.

http://www.emedicinehealth.com/kawasaki_disease/article_em.htm emedicine health kawasaki disease

https://radiopaedia.org/articles/kawasaki-disease radiopedia kawasaki disease

http://www.hse.ie/eng/health/az/k/kawasaki-disease/symptoms-of-kawasaki-disease.html health service executive kawasaki disease



http://europepmc.org/backend/ptpmcrender.fcgi?accid=pmc3855660&blobtype=pdf ogata s, shimizu c, franco a, touma r, kanegaye jt, et al. (2013) treatment response in kawasaki disease is associated with sialylation levels of endogenous but not therapeutic intravenous immunoglobulin g. plos one 8(12): e81448. doi:10.1371/journal.pone.0081448

https://www.hindawi.com/journals/mi/2012/356362/ ruixi liu, bo he, fang gao, qian liu, and qijian yi, “association of the resistin gene promoter region polymorphism with kawasaki disease in chinese children,” mediators of inflammation, vol. 2012, article id 356362, 8 pages, 2012. doi:10.1155/2012/356362

al-mendalawi md. sensorineural hearing loss in kawasaki disease. ann pediatr card [serial online] 2016 [cited 2017 jan 2];9:198-9. available from: http://www.annalspc.com/text.asp?2016/9/2/198/180676

http://europepmc.org/backend/ptpmcrender.fcgi?accid=pmc3722201&blobtype=pdf : kuo h-c, hsu y-w, wu c-m, chen sh-y, hung k-s, et al. (2013) a replication study for association of itpkc and casp3 two-locus analysis in ivig unresponsiveness and coronary artery lesion in kawasaki disease. plos one 8(7): e69685. doi:10.1371/journal.pone.0069685

https://www.hindawi.com/journals/criopm/2013/621952/ elif erdem, emine kocabas, hande taylan sekeroglu, özlem özgür, meltem yagmur, and t. reha ersoz, “crystalline-like keratopathy after intravenous immunoglobulin therapy with incomplete kawasaki disease: case report and literature review,” case reports in ophthalmological medicine, vol. 2013, article id 621952, 4 pages, 2013. doi:10.1155/2013/621952

http://europepmc.org/backend/ptpmcrender.fcgi?accid=pmc4894573&blobtype=pdf whitin jc, yu tt-s, ling xb, kanegaye jt, burns jc, cohen hj (2016) a novel truncated form of serum amyloid a in kawasaki disease. plos one 11(6): e0157024. doi:10.1371/journal.pone.0157024

http://europepmc.org/backend/ptpmcrender.fcgi?accid=pmc3590129&blobtype=pdf shimizu c, kim j, stepanowsky p, trinh c, lau hd, et al. (2013) differential expression of mir-145 in children with kawasaki disease. plos one 8(3):e58159. doi:10.1371/journal.pone.0058159

https://www.hindawi.com/journals/dm/2013/265051/ hwa jin cho, young earl choi, eun song song, young kuk cho, and jae sook ma, “procalcitonin levels in patients with complete and incomplete kawasaki disease,” disease markers, vol. 35, no. 5, article id 265051, 7 pages, 2013. doi:10.1155/2013/265051

https://www.hindawi.com/journals/ecam/2013/605123/ peng yeong woon, wei chiao chang, chi-cheng liang, et al., “increased risk of atopic dermatitis in preschool children with kawasaki disease: a population-based study in taiwan,” evidence-based complementary and alternative medicine, vol. 2013, article id 605123, 7 pages, 2013. doi:10.1155/2013/605123

https://www.hindawi.com/journals/crim/2011/606920/ m. ebrahim, m. gabay, and r. f. rivas-chacon, “evidence of acute mycoplasma infection in a patient with incomplete and atypical kawasaki disease: a case report,” case reports in medicine, vol. 2011, article id 606920, 4 pages, 2011. doi:10.1155/2011/606920

https://www.hindawi.com/journals/ecam/2015/864597/ jiao-yang chen, ji-ming yin, zhong-dong du, jing hao, and hui-min yan, “qing re liang xue decoction alleviates hypercoagulability in kawasaki disease,” evidence-based complementary and alternative medicine, vol. 2015, article id 864597, 6 pages, 2015. doi:10.1155/2015/864597


Other helpful resources(support groups):

http://www.kdfoundation.org/ kawasak disease foundation

http://www.kawasakidiseaseindia.org/ kawasak disease foundation of india

http://www.kdfoundation.org.au/kd/ kawasak disease foundation


Related videos:

https://www.youtube.com/watch?v=kbo1dt4uese kawasaki disease

https://www.youtube.com/watch?v=mk-dn5wvvrk what is kawasaki disease? | circulatory system and disease | nclex-rn | khan academy

https://www.youtube.com/watch?v=stydhtucw48&vl=en kawasaki disease - causes, symptoms, diagnosis, treatment & pathology

https://www.youtube.com/watch?v=c5bbj8uh_3m kawasaki disease

https://www.youtube.com/watch?v=thdcueiequ0 kawasaki disease: animated heart video


Presentations/quiz/newspaper articles:

http://www.foxnews.com/health/2016/07/31/kawasaki-disease-rare-but-serious-childhood-illness.html fox news kawasaki disease: a rare, but serious childhood illness

http://timesofindia.indiatimes.com/life-style/health-fitness/health-news/rare-kawasaki-disease-in-mumbai-doctors-see-12-cases-in-6-months/articleshow/52305333.cms times of india rare kawasaki disease in mumbai, doctors see 12 cases in 6 months

http://komonews.com/news/local/local-doctor-believes-soy-products-can-trigger-kawasaki-disease-in-children komonews doctor believes soy increased risk of kawasaki disease that sickened young boy


http://www.independent.co.uk/news/world/asia/kawasaki-disease-an-unknown-illness-with-no-definitive-medical-diagnosis-and-no-known-cause-but-it-10376403.html independant kawasaki disease: an unknown illness with no definitive medical diagnosis and no known cause – but it may all be in the wind




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