insulinoma
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Insulinoma

Insulinoma

Last Reviewed : 12/24/2020
Insulinoma

An insulinoma is a tumor of the pancreas that is derived from beta cells and secretes insulin. It is a rare form of a neuroendocrine tumor. Most insulinomas are benign in that they grow exclusively at their origin within the pancreas, but a minority metastasize. Insulinomas are one of the functional PanNET group ("functional" because it increases production of insulin; "PanNET" as an abbreviation of pancreatic neuroendocrine tumor). In the Medical Subject Headings classification, insulinoma is the only sub-type of "islet cell adenoma".

Beta cells secrete insulin in response to increases in blood glucose. The resulting increase in insulin acts to lower blood glucose back to normal levels at which point further secretion of insulin is stopped. In contrast, the secretion of insulin by insulinomas is not properly regulated by glucose and the tumors will continue to secrete insulin causing glucose levels to fall further than normal.

As a result, patients present symptoms of low blood glucose (hypoglycemia), which are improved by eating. The diagnosis of an insulinoma is usually made biochemically with low blood glucose, elevated insulin, proinsulin and C-peptide levels and confirmed by localizing the tumor with medical imaging or angiography. The definitive treatment is surgery.

 

We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.

 

Basic information:

http://www.surgery.usc.edu/divisions/tumor/pancreasdiseases/web%20pages/endocrine%20tumors/pancreatic%20tumors/insulinoma.htmlinsulinoma

http://www.healthline.com/health/insulinoma health line insulinoma

https://medlineplus.gov/ency/article/000387.htm medline plus insulinoma

http://www.nytimes.com/health/guides/disease/insulinoma/overview.html new york times insulinoma

http://www.hopkinsmedicine.org/healthlibrary/conditions/liver_biliary_and_pancreatic_disorders/insulinoma_134,219/john hopkins medical library insulinoma

http://www.merckmanuals.com/professional/gastrointestinal-disorders/tumors-of-the-gi-tract/insulinoma merck manuals(professional version) insulinoma

http://www.healthhype.com/insulinoma-insulin-tumors.html health hype insulinoma

http://umm.edu/health/medical/ency/articles/insulinoma university of maryland medical center insulinoma

 

Advanced information:

http://emedicine.medscape.com/article/283039-overview medscape insulinoma

https://radiopaedia.org/articles/insulinoma radiopedia insulinoma

http://www.dovemed.com/diseases-conditions/insulinoma/ dove med insulinoma

http://www.healio.com/endocrinology/diabetes/news/print/endocrine-today/%7b1812136e-6bea-4485-95cb-32def2833f48%7d/insulinoma-with-negative-72-hour-fasting-test-severe-hypoglycemia-after-glucagon healio insulinoma with negative 72-hour fasting test, severe hypoglycemia after glucagon

http://www.diapedia.org/associated-disorders/61040851215/insulinoma diapedia insulinoma

http://www.unboundedmedicine.com/2006/01/15/insulinoma-whipple-triad-surgery/ insulinoma & whipple triad – surgery (update)

 

Research:

Jyotsna vp, raizada n, chakraborty s, pal s. Acanthosis nigricans in insulinoma. Indian j endocr metab [serial online] 2014 [cited 2017 jan 2];18:739. Available from: http://www.ijem.in/text.asp?2014/18/5/739/139223

https://www.hindawi.com/journals/jdr/2012/460869/ p. Dames, m. Weise, r. Puff, et al., “suppression of the nuclear factor eny2 increases insulin secretion in poorly functioning ins-1e insulinoma cells,” experimental diabetes research, vol. 2012, article id 460869, 8 pages, 2012. Doi:10.1155/2012/460869

http://wjso.biomedcentral.com/articles/10.1186/1477-7819-7-18 pancreatic insulinoma co-existing with gastric gist in the absence of neurofibromatosis-1 by edward alabraba et al., world journal of surgical oncology20097:18 doi: 10.1186/1477-7819-7-18

http://europepmc.org/backend/ptpmcrender.fcgi?accid=pmc4433182&blobtype=pdf : hamilton a, basic v, andersson s, abrink m, ringvall m (2015) loss of serglycin promotes primary tumor growth and vessel functionality in the rip1-tag2 mouse model for spontaneous insulinoma formation. Plos one 10(5): e0126688. Doi:10.1371/journal.pone.0126688

https://www.hindawi.com/journals/omcl/2016/2594703/ han sung kim, tae-young han, and yeong-min yoo, “melatonin-mediated intracellular insulin during 2-deoxy-d-glucose treatment is reduced through autophagy and edc3 protein in insulinoma ins-1e cells,”oxidative medicine and cellular longevity, vol. 2016, article id 2594703, 11 pages, 2016. Doi:10.1155/2016/2594703

http://bmcmolbiol.biomedcentral.com/articles/10.1186/1471-2199-8-41 leptin induces inflammation-related genes in rinm5f insulinoma cells by paul hekerman et al., bmc molecular biology20078:41 doi: 10.1186/1471-2199-8-41

http://europepmc.org/backend/ptpmcrender.fcgi?accid=pmc4368701&blobtype=pdf : kim mk, cho jh, lee jj, son mh, lee kj (2015) proteomic analysis of ins-1 rat insulinoma cells: er stress effects and the protective role of exenatide, a glp-1 receptor agonist. Plos one 10(3): e0120536. Doi:10.1371/journal.pone.0120536

Arunraj s t, damle na, bal c, gupta y, pal s. Insulinoma - the incremental value of somatostatin receptor positron emission tomography. Indian j endocr metab [serial online] 2017 [cited 2017 jan 2];21:255-6. Available from: http://www.ijem.in/text.asp?2017/21/1/255/196025

http://europepmc.org/backend/ptpmcrender.fcgi?accid=pmc3589424&blobtype=pdf teraoka y, ide k, morimoto h, tahara h, ohdan h (2013) expression of recipient cd47 on rat insulinoma cell xenografts prevents macrophagemediated rejection through sirpa inhibitory signaling in mice. Plos one 8(3): e58359. Doi:10.1371/journal.pone.0058359

http://europepmc.org/backend/ptpmcrender.fcgi?accid=pmc3329476&blobtype=pdf lee ns, rohan jg, zitting m, kamath s, weitz a, et al. (2012) a novel dual-color reporter for identifying insulin-producing beta- cells and classifying heterogeneity of insulinoma cell lines. Plos one 7(4): e35521. Doi:10.1371/journal.pone.0035521

https://www.hindawi.com/journals/cris/2015/375124/ ersin borazan, alper aytekin, latif yilmaz, et al., “multifocal insulinoma in pancreas and effect of intraoperative ultrasonography,” case reports in surgery, vol. 2015, article id 375124, 4 pages, 2015. Doi:10.1155/2015/375124

https://www.hindawi.com/journals/crie/2012/168671/ a. Janez, “insulinoma causing liver metastases 15 years after initial surgery, accompanied by glomerulonephritis,” case reports in endocrinology, vol. 2012, article id 168671, 3 pages, 2012. Doi:10.1155/2012/168671

https://www.hindawi.com/journals/crie/2013/636175/ emre bozkirli, okan bakiner, huseyin abali, et al., “a case of inoperable malignant insulinoma with resistant hypoglycemia who experienced the most significant clinical improvement with everolimus,” case reports in endocrinology, vol. 2013, article id 636175, 6 pages, 2013. Doi:10.1155/2013/636175

https://www.ncbi.nlm.nih.gov/pmc/articles/pmc3574879/ okabayashi t, shima y, sumiyoshi t, et al. Diagnosis and management of insulinoma. World journal of gastroenterology?: wjg. 2013;19(6):829-837. Doi:10.3748/wjg.v19.i6.829.

 

Other articles:

http://www.petmd.com/dog/conditions/cancer/c_multi_insulinoma pet md pancreatic cancer (insulinoma) in dogs

https://www.acvs.org/small-animal/insulinoma american college of veterinary surgeons insulinoma

http://www.peteducation.com/article.cfm?c=11+2061&aid=550 pet education insulinoma: diagnosis and treatment

http://www.2ndchance.info/insulinoma.htm 2nd chance insulinoma in ferrets

http://vetspecialists.co.uk/factsheets/oncology_facts/canine_insulinoma.html davis vetarinary specialists canine insulinoma

http://www.petcarevb.com/ferret-veterinarian/ferret-insulinoma.php pet care insulinoma

http://www.vcahospitals.com/main/pet-health-information/article/animal-health/insulinomas-in-ferrets/4194 vca animal hospitals insulinomas in ferrets

 

Other helpful resources(support groups):

https://insulinoma.co.uk/ insulinoma support network

 

Related videos:

https://www.youtube.com/watch?v=twbx79fzot4 insulinoma

https://www.youtube.com/watch?v=tj-ko5fb3qg insulinoma

https://www.youtube.com/watch?v=lxvuf0f7oie laparoscopic enculeation of insulinoma

https://www.youtube.com/watch?v=_tegjdhjs2o insulinoma

https://www.youtube.com/watch?v=tf1phjhrzlg diagnosis of insulinoma by eus

https://www.youtube.com/watch?v=r1ektxadjfo histopathology pancreas --islet cell tumor (insulinoma)

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