Histoplasmosis (also known as "Cave disease ") is a disease caused by the fungus Histoplasma capsulatum. Symptoms of this infection vary greatly, but the disease affects primarily the lungs. Occasionally, other organs are affected; this is called disseminated histoplasmosis, and it can be fatal if left untreated.
The acute phase of histoplasmosis is characterized by non-specific respiratory symptoms, often cough or flu-like. In the majority of immunocompetent individuals, histoplasmosis resolves without any treatment. Antifungal medications are used to treat severe cases of acute histoplasmosis and all cases of chronic and disseminated disease. Typical treatment of severe disease first involves treatment with amphotericin B, followed by oral itraconazole.
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http://cid.oxfordjournals.org/content/45/7/807.full.pdf+html. Cid (clinical infectious diseases). Clinical practice guidelines for the management of patients with histoplasmosis: 2007 update by the infectious diseases society of america l. Joseph wheat, alison g. Freifeld, martin b. Kleiman, john w. Baddley, david s. Mckinsey, james e. Loyd, and carol a. Kauffman.
http://www.japi.org/march2005/o-185.pdf. Japi (journal of the association of physicians of india). Disseminated histoplasmosis by s subramanian, oc abraham, priscilla rupali, a zachariah, mary s mathews, d mathai.