Herpes simplex encephalitis

Herpes simplex encephalitis

Last Reviewed : 12/28/2020
Herpes simplex encephalitis

Herpesviral encephalitis is encephalitis due to herpes simplex virus.

Herpes simplex encephalitis (HSE) is a viral infection of the human central nervous system. It is estimated to affect at least 1 in 500,000 individuals per year and some studies suggest an incidence rate of 5.9 cases per 100,000 live births. The majority of cases of herpes encephalitis are caused by herpes simplex virus-1 (HSV-1), the same virus that causes cold sores. 57% of American adults are infected with HSV-1, which is spread through droplets, casual contact, and sometimes sexual contact, though most infected people never have cold sores. About 10% of cases of herpes encephalitis are due to HSV-2, which is typically spread through sexual contact. About 1 in 3 cases of HSE result from primary HSV-1 infection, predominantly occurring in individuals under the age of 18; 2 in 3 cases occur in seropositive persons, few of whom have history of recurrent orofacial herpes. Approximately 50% of individuals that develop HSE are over 50 years of age.


We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.


Basic information:

Http://www.mayoclinic.org/diseases-conditions/encephalitis/basics/causes/con-20021917 mayoclinic

Http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/herpes_meningoencephalitis_134,27/john hopkins medicine herpes meningoencephalitis

Https://rarediseases.info.nih.gov/diseases/6649/herpes-simplex-encephalitis herpes simplex encephalitis

Http://www.healthline.com/health/encephalitis health line encephalitis

Http://neuropathology-web.org/chapter5/chapter5dviruses.html infections of the nervous system

Http://umm.edu/health/medical/reports/articles/viral-encephalitis university ofmaryland medical center viral encephalitis

Http://www.webmd.com/a-to-z-guides/understanding-encephalitis-basicsv web mdunderstanding encephalitis -- the basics

Http://lifeinthefastlane.com/ccc/hsv-encephalitis/ life in the fast lane hsv encephalitis


Advanced information:

Http://emedicine.medscape.com/article/1165183-overview medscape herpes simplex encephalitis

Http://emedicine.medscape.com/article/1165183-clinical medscape herpes simplex encephalitis clinical presentation

Https://rarediseases.org/rare-diseases/encephalitis-herpes-simplex/ national organisationfor rare diseases herpes simplex encephalitis

Https://radiopaedia.org/articles/herpes-simplex-encephalitis radiopedia herpes simplex encephalitis

Http://patient.info/doctor/encephalitis-pro patient encephalitis

Http://www.aafp.org/afp/2002/0315/p1138.html neonatal herpes simplex virus infections caroline m. Rudnick, m.d., ph.d., st. Anthony's medical center, st. Louis, missouri,grant s. Hoekzema, m.d., st. John's mercy medical center, st. Louis, missouri am fam physician. 2002 mar 15;65(6):1138-1142.

Http://www.pathologyoutlines.com/topic/cnshsvencephalitis.html pathology outlines herpes simplex encephalitis

Http://www.epilepsy.com/information/professionals/co-existing-disorders/infectious-states-seizures/viral-infections/herpes epilepsy foundation herpes encephalitis



Takeuchi s, takasato y. Herpes simplex virus encephalitis complicated by intracerebral hematoma. Neurol india [serial online] 2011 [cited 2016 dec 1];59:594-6. Available from: http://www.neurologyindia.com/text.asp?2011/59/4/594/84344

Http://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-9-270 inflammatory monocytes and the pathogenesis of viral encephalitis by rachael l terry et al, journal of neuroinflammation20129:270 doi: 10.1186/1742-2094-9-270

Http://www.scielo.br/scielo.php?Script=sci_arttext&pid=s0004-282x2001000100024 arq. Neuro-psiquiatr. Vol.59 no.1 são paulo mar. 2001 http://dx.doi.org/10.1590/s0004-282x2001000100024 cerebral aneurysmal dilatation in an infant with perinatally acquired hiv infection and hsv encephalitis by magda lahorgue nunes et al.,

Http://cid.oxfordjournals.org/content/35/3/254.long outcome of and prognostic factors for herpes simplex encephalitis in adult patients: results of a multicenter study by franck raschilas et al., clin infect dis. (2002) 35 (3):254-260.doi: 10.1086/341405

Panagariya a, jain r s, gupta s, garg a, sureka r k, mathur v. Herpes simplex encephalitis in north west india. Neurol india [serial online] 2001 [cited 2016 dec 1];49:360. Available from: http://www.neurologyindia.com/text.asp?2001/49/4/360/1220

Https://www.jci.org/articles/view/59259 herpes simplex encephalitis in children with autosomal recessive and dominant trif deficiency by vanessa sancho-shimizu et al., j clin invest. 2011;121(12):4889-4902. Doi:10.1172/jci59259

Https://www.hindawi.com/journals/crinm/2015/673724/ peter a. Abdelmalik, timothy ambrose, and rodney bell, “herpes simplex viral encephalitis masquerading as a classic left mca stroke,” case reports in neurological medicine, vol. 2015, article id 673724, 5 pages, 2015. Doi:10.1155/2015/673724

Http://www.scielo.br/scielo.php?Script=sci_arttext&pid=s0004-282x2004000100024 arq. Neuro-psiquiatr. Vol.62 no.1 são paulo mar. 2004 http://dx.doi.org/10.1590/s0004-282x2004000100024 acute hemorrhagic leukoencephalitis mimicking herpes simplex encephalitis: case report by henrique milhomem martins et al.,

Http://aac.asm.org/content/55/7/3624.long valacyclovir for herpes simplex encephalitis by thomas pouplin et al.,accepted manuscript posted online 16 may 2011, doi:10.1128/aac.01023-10antimicrob. Agents chemother.july 2011 vol. 55 no. 7 3624-3626

Http://www.jwatch.org/na37593/2015/04/22/temporal-lobe-encephalitis-distinguishing-herpes-simplex chow fc et al. Use of clinical and neuroimaging characteristics to distinguish temporal lobe herpes simplex encephalitis from its mimics. Clin infect dis 2015 may 1; 60:1377.

Http://journals.plos.org/plosone/article?Id=10.1371/journal.pone.0155531 prevalence of intrathecal acyclovir resistant virus in herpes simplex encephalitis patients by johanna g. Mitterreiter et al,http://dx.doi.org/10.1371/journal.pone.0155531

Http://www.nature.com/icb/journal/v93/n10/full/icb201573a.html immunology and cell biology (2015) 93, 839–840; doi:10.1038/icb.2015.73; published online 11 august 2015 limiting herpes simplex encephalitis battling the spread: herpes simplex virus and encephalitis by christina m slifer et al.,


Related videos:

Https://www.youtube.com/watch?V=rkeilix_vkw herpes simplex encephalitis symptoms and treatment

Https://www.youtube.com/watch?V=xpm4y2nlu5w herpes simplex encephalitis | herpes simplex keratitis

Https://www.youtube.com/watch?V=wycfpxbejoy herpes encephalitis symptoms

Https://www.youtube.com/watch?V=db587o5x5xm herpes simplex encephalitis

Https://www.youtube.com/watch?V=25zzjob0aqe hsv encephalitis


Presentations/quiz/newspaper articles:

Http://www.nbcnews.com/id/42994138/ns/health-infectious_diseases/t/man-flips-truck-after-cold-sore-virus-travels-his-brain/#.weaaynkufp0 nbc news steve johnson blacked out and rolled his truck on a rural washington state road last spring. He was later diagnosed with herpes encephalitis, a rare and dangerous infection triggered by the same virus that causes cold sores. Johnson, shown at work at the gorge fly shop in hood river, ore., says he still suffers lingering memory issues. "i've lost memories from early in my marriage," he says, "i try not to think about it too much. It's depressing."

Please leave your comments:

Related Articles