Herpes Infection/Genital Herpes/ Fever Blisters/ Cold Sores/ Hsv-1/ Hsv-2

Herpes Infection/Genital Herpes/ Fever Blisters/ Cold Sores/ Hsv-1/ Hsv-2

Last Reviewed : 12/28/2020
Herpes Infection/Genital Herpes/ Fever Blisters/ Cold Sores/ Hsv-1/ Hsv-2

Herpes simplex viruses (human herpesviruses types 1 and 2) commonly cause recurrent infection affecting the skin, mouth, lips, eyes, and genitals. Common severe infections include encephalitis, meningitis, neonatal herpes, and, in immunocompromised patients, disseminated infection. Mucocutaneous infections cause clusters of small painful vesicles on an erythematous base. Diagnosis is clinical; laboratory confirmation by culture, PCR, direct immunofluorescence, or serologic testing can be done. Treatment is symptomatic; antiviral therapy with acyclovir, valacyclovir, or famciclovir is helpful for severe infections and, if begun early, for recurrent or primary infections.


We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.


Basic information:

https://www.aad.org/public/diseases/contagious-skin-diseases/herpes-simplex american academy of dermatology.org. Herpes simplex.

http://www.dermnetnz.org/viral/herpes-simplex.html dermnetnewzealand. Herpes simplex

http://www.who.int/mediacentre/factsheets/fs400/en/ world health organization. Herpes simplex virus.

http://www.mayoclinic.org/diseases-conditions/genital-herpes/basics/definition/con-20020893 mayoclinic. Genital herpes.

http://www.nhs.uk/conditions/genital-herpes/pages/introduction.aspx the national health service.united kingdom. Genital herpes.

http://umm.edu/health/medical/reports/articles/herpes-simplex university of maryland medical center. Herpes simplex.

http://www.idph.state.il.us/public/hb/hbherpes.htm illinois department of public health. Genital herpes.

http://www.encyclopedia.com/doc/1g2-3437000161.html encyclopedia. Herpes infections.

http://www.humanillnesses.com/infectious-diseases-he-my/herpes-simplex-virus-infections.html human illnesses. Herpes simplex virus infections.

https://www.poz.com/basics/hiv-basics/herpes-simplex-virus poz.com. Herpes simplex virus (oral and genital herpes).

http://www.abc.net.au/health/library/stories/2005/05/05/1831287.htm abc health and wellbeimgherpes simplex virus.


Advanced information:

http://www.msdmanuals.com/professional/infectious-diseases/herpesviruses/herpes-simplex-virus-hsv-infectionsmerck sharp & dohme manuals.

http://emedicine.medscape.com/article/218580-overview emedicine.medscape.com. Herpes simplex by michelle r salvaggio.

http://www.emedicinehealth.com/oral_herpes/article_em.htm emedicinehealth.com. Oral herpes (hsv-1) (herpes of the mouth).

http://www.arhp.org/publications-and-resources/quick-reference-guide-for-clinicians/sexually-transmitted-infections-and-associated-conditions/genital-herpes- association of reproductive health professionals. Genital herpes.

http://www.nytimes.com/health/guides/disease/genital-herpes/print.html newyork times. Genital herpes in-depth report.

http://pennstatehershey.adam.com/content.aspx?productid=10&pid=10&gid=000052 penn state hershey health information. Herpes simplex.

http://www.phac-aspc.gc.ca/std-mts/sti-its/cgsti-ldcits/section-5-4-eng.php public health agency of canada. Genital herpes simplex virus (hsv) infections.

http://virology-online.com/viruses/hsv2.htm virology online.pathogenesis of herpes simplex viruses infection.

https://doaj.org/article/e75578050c284926a4ff51d997d5c207 directory of open access journals. Oro-facial herpes zoster: a case report with a detailed review of literature by satyaranjan mishra et al. Oral & maxillofacial pathology journal. 2013;4(1)346-354



http://ije.oxfordjournals.org/content/26/4/698.full.pdf international journal of epidemology.oxford journals.genital herpes infection: a review by r. Brugha et al.

http://www.antimicrobe.org/v30.asp antimicrobe. Herpes simplex virus by david w. Kimberlin, m.d.

http://www.nature.com/nrneurol/journal/v3/n2/full/ncpneuro0401.html nature.com. Herpesvirus infections of the nervous system by donald h gilden et al.

http://jvi.asm.org/content/77/17/9533.long journal of virology.latent herpes simplex virus infection of sensory neurons alters neuronal gene expression by martha f. Kramer et al. Doi: 10.1128/jvi.77.17.9533-9541.2003 j. Virol. September 2003 vol. 77 no. 17 9533-9541

http://www.pnas.org/content/94/19/10289.full.pdf proceedings of the national academy of sciences of the united states of america. Severe genital herpes infections in hiv-infected individuals with impaired herpes simplex virus-specific cd81 cytotoxic t lymphocyte responses by christine m. Posavad et al.

https://doaj.org/article/2cd203aacf184492b815e1031c4e1359 directory of open access journals. Herpesviruses placating the unwilling host: manipulation of the mhc class ii antigen presentation pathway by martin rowe , jianmin zuo. Viruses. 2012;4(8)1335-1353 doi 10.3390/v4081335

https://doaj.org/article/2d6b881c1d944b42a6915c8d11aca954 directory of open access journals. Directional spread of alphaherpesviruses in the nervous system viruses by lynn w. Enquist, tal kramer. 2013;5(2)678-707 doi 10.3390/v5020678

https://doaj.org/article/0d91aef3a8aa425ab3becd9f636a21f6 directory of open access journals. T cell memory in the context of persistent herpes viral infections by nicole torti, annette oxenius. Viruses 2012;4(7)1116-1143 doi 10.3390/v4071116

https://doaj.org/article/03c531a0e9ef4d71a99b552c6c35b20a directory of open access journals. Herpes simplex virus induces neural oxidative damage via microglial cell toll-like receptor-2 by little morgan r et al. Journal of neuroinflammation. 2010;7(1)35 doi 10.1186/1742-2094-7-35

https://doaj.org/article/028816c8b6e64c0aa26bca027879d7cf directory of open access journals. Activation of pi3k/akt and erk mapk signal pathways is required for the induction of lytic cycle replication of kaposi's sarcoma-associated herpesvirus by herpes simplex virus type 1 by lv zhigang et al. Bmc microbiology. 2011;11(1)240 doi 10.1186/1471-2180-11-240

https://doaj.org/article/01b561431ea24dabbc23b050ef651d2f directory of open access journals. Herpes simplex virus induces the marked up-regulation of the zinc finger transcriptional factor insm1, which modulates the expression and localization of the immediate early protein icp0 by kimura hiroshi et al. Virology journal. 2011;8(1)257 doi 10.1186/1743-422x-8-257

https://doaj.org/article/417843b814224d10ac7a800f29b5f530 directory of open access journals. Exploiting herpes simplex virus entry for novel therapeutics by deepak shukla, satvik hadigal. Viruses. 2013;5(6)1447-1465 doi 10.3390/v5061447

https://doaj.org/article/302cc3edf3cb4144bee61a9fe50b64cd directory of open access journals. The dynamics of hcf-1 modulation of herpes simplex virus chromatin during initiation of infection by thomas m. Kristie, jodi l. Vogel. Viruses. 2013;5(5)1272-1291 doi 10.3390/v5051272

https://doaj.org/article/00be52cd127142b3b16d605bdc757498 directory of open access journals. Oncolytic herpes viruses, chemotherapeutics, and other cancer drugs by braidwood l et al. Oncolytic virotherapy. 2013;2013(issue 1)57-74


Related topics:

http://www.stdwizard.org/#/home std wizard

https://www.myonlinesexualhealth.com/assessment.php my online sexual health

http://www.proprofs.com/quiz-school/story.php?title=what-std-do-i-have propofs.com. What std do i have?

http://www.gurl.com/2011/06/28/could-you-have-an-std-sexually-transmitted-disease-quiz/ gurl.com. Could you have an std?

https://doaj.org/article/2eb32397f143401998d1034be35fba61 directory of open access journals. Herpes simplex reactivation or postinfectious inflammatory response after epilepsy surgery: case report and review of the literature by anna lo presti et al. Surgical neurology international. 2015;6(1)47-47 doi 10.4103/2152-7806.153882

https://doaj.org/article/73cf55d81b904ccd808f8e22224b82b5 directory of open access journals. Herpes zoster ophthalmicus: disease spectrum in young adults by noopur gupta et al. Middle east african journal of ophthalmology. 2011;18(2)178-182 doi 10.4103/0974-9233.80710

https://doaj.org/article/d89c98f34f3a4836b91f6652aec21415 directory of open access journals. Herpes zoster: a clinicopathologic correlation with literature review by n malathi et al. Oral & maxillofacial pathology journal. 2014;5(1)449-452 doi 10.5005/10037-1009

https://doaj.org/article/d9b3d87cd2b64f979ed730200ab8c186 directory of open access journals. Zoster vaccine live for the prevention of shingles in the elderly patient by jamie zussman , lorraine young. Clinical interventions in aging. 2008;2008(issue 2)241-250


General articles:

http://www.skinsight.com/adult/herpeticwhitlow.htm?imiw9capl skinsiht.com. Herpetic whitlow.

http://www.aafp.org/afp/2002/0315/p1138.html american family physician. Neonatal herpes simplex virus infections by caroline m. Rudnick et al.

http://www.allaboutvision.com/conditions/ocular-herpes.htm all about vision.comeye herpes (ocular herpes) by jessica hill.

http://archneur.jamanetwork.com/article.aspx?articleid=795486 journal of american medical association. Neurological complications of herpes simplex virus type 2 infection by joseph r. Berger, md et al.

http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/herpes_meningoencephalitis_134,27/hopkins medicine. Herpes meningoencephalitis.

https://www.reviewofoptometry.com/ce/an-overview-of-ocular-herpetic-disease review of optometry. An overview of ocular herpetic disease.

http://www.ijidonline.com/article/s1201-9712(09)00244-6/abstract international society for infectious diseases. Chronic urticaria associated with recurrent genital herpes simplex infection and success of antiviral therapy — a report of two cases by vijay zawar et al. Doi: http://dx.doi.org/10.1016/j.ijid.2009.06.008

http://www.scielo.br/scielo.php?script=sci_arttext&pid=s0036-46652011000200010 scielo. Refractory pemphigus vulgaris associated with herpes infection: case report and review. By maria luiza figueiredo braga brandão et al. Issn 0036-4665 rev. Inst. Med. Trop. S. Paulo vol.53 no.2 são paulo mar./apr. 2011 http://dx.doi.org/10.1590/s0036-46652011000200010

https://doaj.org/article/43fd8a70e5734352b6cb084f110927a8 directory of open access journals. A review article on herpes simplex encephalitis by a. Karimi md et al. Iranian journal of child neurology. 2009;1(3)5-11

https://doaj.org/article/ad7959f542554d2eaa6572c7150a9f6c directory of open access journals. Herpesvirus infection and infectious mononucleosis by e. V. Sharipova et al. Žurnal infektologii. 2014;5(2)5-12

https://doaj.org/article/78a90a3b490849e28b9e73d2fba473f7 directory of open access journals. Herpes associated erythema multiforme by k a kamala. Contemporary clinical dentistry. 2011;2(4)372-375 doi 10.4103/0976-237x.91807


Other articles:

http://hivinsite.ucsf.edu/insite?page=kb-05-03-02#s1x hivinsite.university of california,san fransisco. Herpes simplex virus and hiv-1 by jared m. Baeten, connie celum.

https://www.verywell.com/herpes-simplex-and-hearing-loss-1048687 verywell.com. Herpes simplex and hearing loss by jamie berke.

http://www.disabled-world.com/artman/publish/vaginal_herpes.shtml disabled world information. Vaginal yeast or vaginal herpes?

https://clinicaltrials.gov/ct2/show/nct00000985 clinicaltrials.gov. Comparison of foscarnet versus vidarabine in the treatment of herpes infection in patients with aids who have not had success with acyclovir by s safrin.

http://pediatrics.aappublications.org/content/pediatrics/131/2/e635.full.pdf pediatrics aapublications. Guidance on management of asymptomatic neonates born to women with active genital herpes lesions by david w. Kimberlin et al.

https://www.rcog.org.uk/globalassets/documents/guidelines/genitalherpesotherguideline.pdf royal college of obstetricians and gynaecologists. Management of genital herpes in pregnancy.

http://www.cps.ca/documents/position/prevention-management-neonatal-herpes-simplex-virus-infections canadian paediatric society. Prevention and management of neonatal herpes simplex virus infections by upton d allen, joan l robinson.

http://sogc.org/wp-content/uploads/2013/01/gui208cpg0806.pdf e society of

Obstetricians and gynaecologists of canada. Guidelines for the management of herpes

Simplex virus in pregnancy by deborah money et al.

https://www.gsksource.com/pharma/content/dam/glaxosmithkline/us/en/prescribing_information/valtrex/pdf/valtrex-pi-pil.pdf glaxosmithkline source. Highlights of prescribing information for valtrex.

https://doaj.org/article/03f625d16f3c47789e1e30aba98980b3 directory of open access journals. Correlation of cervical dysplasia with serological and microbiological tests for genital infections by ishita (ghosh) et al. Journal of evolution of medical and dental sciences. 2015;4(2)176-183 doi 10.14260/jemds/2015/29

https://doaj.org/article/1c9958136a3d4195b17fb231be5bc498 directory of open access journals. Acyclovir and hydrocortisone cream for the early treatment of recurrent cold sores by carrie a sailer et al. Virus adaptation and treatment. 2011;2011(default)1-6

https://doaj.org/article/9670f99b8ac94c0590d76e21ac761dfc directory of open access journals. Hsv-1 and alzheimer’s disease: more than a hypothesis by claudiograssi et al. Frontiers in pharmacology. 2014;5 doi 10.3389/fphar.2014.00097


Other useful resources:

http://www.herpes.org.nz/ new zealand herpes foundation.

http://www.herpes.com/index.html herpes.com

http://www.fpa.org.uk/ family planning association.united kingdom.

http://www.herpes.org/ herpes.org

http://www.eadv.org/ european academy of dermatology and venereology.

http://www.britishskinfoundation.org.uk/home.aspx the british skin foundation.


Related vedios:

https://www.youtube.com/watch?v=kflwsrliomm youtube.com. Herpes simplex virus.

https://www.youtube.com/watch?v=zihxaikdnec youtube. Genital herpes - what causes genital herpes, symptoms & treatment for genital herpes. Prevent herpes.

https://www.youtube.com/watch?v=c2ihfilwbay .youtube.com. Herpes simplex virus 1 | herpes simplex virus 2

https://www.youtube.com/watch?v=foo0ioyg0ig youtube.com. Herpes simplex virus.



http://www.medicinenet.com/image-collection/herpes_simplex_virus_type_2_picture/picture.htm medicine.net.com. Picture of herpes simplex virus type 2.

http://www.emedicinehealth.com/slideshow_cold_sores/article_em.htm emedicinehealth.com. Cold sores: pictures, coping, treatment and prevention.

http://hardinmd.lib.uiowa.edu/dermnet/herpessimplex.html Hardin MD. Herpes Simplex Pictures.

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