Herpes simplex viruses (human herpesviruses types 1 and 2) commonly cause recurrent infection affecting the skin, mouth, lips, eyes, and genitals. Common severe infections include encephalitis, meningitis, neonatal herpes, and, in immunocompromised patients, disseminated infection. Mucocutaneous infections cause clusters of small painful vesicles on an erythematous base. Diagnosis is clinical; laboratory confirmation by culture, PCR, direct immunofluorescence, or serologic testing can be done. Treatment is symptomatic; antiviral therapy with acyclovir, valacyclovir, or famciclovir is helpful for severe infections and, if begun early, for recurrent or primary infections.
We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.
http://jvi.asm.org/content/77/17/9533.long journal of virology.latent herpes simplex virus infection of sensory neurons alters neuronal gene expression by martha f. Kramer et al. Doi: 10.1128/jvi.77.17.9533-9541.2003 j. Virol. September 2003 vol. 77 no. 17 9533-9541
http://www.pnas.org/content/94/19/10289.full.pdf proceedings of the national academy of sciences of the united states of america. Severe genital herpes infections in hiv-infected individuals with impaired herpes simplex virus-specific cd81 cytotoxic t lymphocyte responses by christine m. Posavad et al.
https://doaj.org/article/028816c8b6e64c0aa26bca027879d7cf directory of open access journals. Activation of pi3k/akt and erk mapk signal pathways is required for the induction of lytic cycle replication of kaposi's sarcoma-associated herpesvirus by herpes simplex virus type 1 by lv zhigang et al. Bmc microbiology. 2011;11(1)240 doi 10.1186/1471-2180-11-240
https://doaj.org/article/01b561431ea24dabbc23b050ef651d2f directory of open access journals. Herpes simplex virus induces the marked up-regulation of the zinc finger transcriptional factor insm1, which modulates the expression and localization of the immediate early protein icp0 by kimura hiroshi et al. Virology journal. 2011;8(1)257 doi 10.1186/1743-422x-8-257
https://doaj.org/article/2eb32397f143401998d1034be35fba61 directory of open access journals. Herpes simplex reactivation or postinfectious inflammatory response after epilepsy surgery: case report and review of the literature by anna lo presti et al. Surgical neurology international. 2015;6(1)47-47 doi 10.4103/2152-7806.153882
https://doaj.org/article/03f625d16f3c47789e1e30aba98980b3 directory of open access journals. Correlation of cervical dysplasia with serological and microbiological tests for genital infections by ishita (ghosh) et al. Journal of evolution of medical and dental sciences. 2015;4(2)176-183 doi 10.14260/jemds/2015/29