Hepatocellular cancer

Hepatocellular cancer

Last Reviewed : 12/28/2020
Hepatocellular cancer

Hepatocellular carcinoma (HCC), also called malignant hepatoma, is the most common type of liver cancer.

Most cases of HCC are as a result of either a viral hepatitis infection (hepatitis B or C), metabolic toxins such as alcohol or aflatoxin), conditions like hemochromatosis and alpha 1-antitrypsin deficiency or NASH.

Treatment options for HCC and prognosis are dependent on many factors but especially on tumour size, staging, and extent of liver injury. Tumour grade is also important; high-grade tumors will have a poor prognosis, while low-grade tumors may go unnoticed for many years, as is the case in many other organs.

HCC is relatively uncommon in the United States and many other developed countries. It occurs most commonly in countries were hepatitis B infections are common.


We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.


Basic information:

https://www.nlm.nih.gov/medlineplus/ency/article/000280.htm medline plus liver cancer - hepatocellular carcinoma

http://www.webmd.com/cancer/hepatocellular-carcinoma webmd hepatocellular carcinoma

http://www.surgery.ucsf.edu/conditions--procedures/hepatocellular-carcinoma-(primary-liver-cancer).aspx university of san fransisco adult primary liver cancer treatment (pdq®)–patient version general information about adult primary liver cancer

http://www.msdmanuals.com/professional/hepatic-and-biliary-disorders/liver-masses-and-granulomas/hepatocellular-carcinoma msd manuals (professional) hepatocellular carcinoma

http://umm.edu/health/medical/ency/articles/hepatocellular-carcinoma university of maryland liver cancer - hepatocellular carcinoma


Advanced information:

http://emedicine.medscape.com/article/197319-overview medscape hepatocellular carcinoma

http://www.cancer.gov/types/liver/hp/adult-liver-treatment-pdq cancer.gov national cancer institute adult primary liver cancer treatment (pdq®)–health professional version

http://patient.info/doctor/primary-liver-cancer-pro patient primary liver cancer

http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/hematology-oncology/hepatocellular-carcinoma/ clevland clinic hepatocellular carcinoma

http://radiopaedia.org/articles/hepatocellular-carcinoma radiopedia hepatocellular carcinoma

Bentham science publishers. "towards the goal of precision therapy in hepatocellular carcinoma: hepatocellular carcinoma is a highly lethal disease, therefore effective and tolerable treatment is urgently needed." sciencedaily. Sciencedaily, 7 march 2016. Www.sciencedaily.com/releases/2016/03/160307152830.htm .

http://onlinelibrary.wiley.com/doi/10.1002/cld.98/pdf histopathologic features of hepatocellular carcinoma by elizabeth m. Brunt, m.d. Clinical liver diseasevolume 1, issue 6, version of record online: 23 jan 2013

http://www.fpnotebook.com/gi/hemeonc/hptcllrcrcnm.htm family practise notebook hepatocellular carcinoma

http://emedicine.medscape.com/article/197319-treatment medscape hepatocellular carcinoma treatment & management



Jazieh ka, arabi m, khankan aa. Transarterial therapy: an evolving treatment modality of hepatocellular carcinoma. Saudi j gastroenterol [serial online] 2014 [cited 2016 jun 14];20:333-41. Available from: http://www.saudijgastro.com/text.asp?2014/20/6/333/145315

Shimizu m, shirakami y, imai k, takai k, moriwaki h. Acyclic retinoid in chemoprevention of hepatocellular carcinoma: targeting phosphorylated retinoid x receptor-a for prevention of liver carcinogenesis. J carcinog [serial online] 2012 [cited 2016 jun 14];11:11. Available from: http://www.carcinogenesis.com/text.asp?2012/11/1/11/100398

http://www.sciencedirect.com/science/article/pii/s2211383511000396 molecular mechanism for the involvement of nuclear receptor fxr in hbv-associated hepatocellular carcinoma by yong-dong niu et al., acta pharmaceutica sinica b volume 1, issue 2, august 2011, pages 73–79 doi:10.1016/j.apsb.2011.06.001

http://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230x-12-170 role of vitamin k2 in preventing the recurrence of hepatocellular carcinoma after curative treatment: a meta-analysis of randomized controlled trials by irbaz bin riaz et al., bmc gastroenterologybmc series ¿ open, inclusive and trusted201212:170 doi: 10.1186/1471-230x-12-170

http://www.mdpi.com/1999-4915/5/3/858/htm deregulation of epigenetic mechanisms by the hepatitis b virus x protein in hepatocarcinogenesis by ourania m. Andrisani viruses 2013, 5(3), 858-872; doi:10.3390/v5030858

http://www.mdpi.com/2072-6694/4/1/165/htm hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma in japan by hiroki nishikawa cancers 2012, 4(1), 165-183; doi:10.3390/cancers4010165

Oishi n, wang xw. Novel therapeutic strategies for targeting liver cancer stem cells. Int j biol sci 2011; 7(5):517-535. Doi:10.7150/ijbs.7.517. Available fromhttp://www.ijbs.com/v07p0517.htm

http://www.scopemed.org/fulltextpdf.php?mno=178306 cytokine induced killer cell immunotherapy in cancer treatment:from bench to bedside by arashar arafar et al., biomedical research and therapy 2014, 1(2):71-77 doi 10.7603/s40730-014-0012-7

http://wjso.biomedcentral.com/articles/10.1186/1477-7819-10-163 meta-analysis of surgical resection and radiofrequency ablation for early hepatocellular carcinoma by gang xu et al., world journal of surgical oncology201210:163 doi: 10.1186/1477-7819-10-163

http://europepmc.org/backend/ptpmcrender.fcgi?accid=pmc4537229&blobtype=pdf : shih c-a, chen w-c, yu h-c, cheng j-s,lai k-h, hsu j-t, et al. (2015) risk of severe acute exacerbation of chronic hbv infection cancer patients who underwent chemotherapy and did not receive anti-viral prophylaxis. Plos one 10(8): e0132426. Doi:10.1371/journal.pone.0132426

http://www.mdpi.com/1422-0067/16/9/22527/htm the role of hmgb1 signaling pathway in the development and progression of hepatocellular carcinoma: a review by xuanbin wang et al., int. J. Mol. Sci. 2015, 16(9), 22527-22540; doi:10.3390/ijms160922527

http://wjso.biomedcentral.com/articles/10.1186/1477-7819-5-144 thyroid metastasis in a patient with hepatocellular carcinoma: case report and review of literature by hung-hua liang et al., world journal of surgical oncology20075:144 doi: 10.1186/1477-7819-5-144

http://www.mdpi.com/2075-4418/6/1/3/htm hepatocellular carcinoma, fibrolamellar variant: diagnostic pathologic criteria and molecular pathology update. A primer by consolato m. Sergi diagnostics 2016, 6(1), 3; doi:10.3390/diagnostics6010003

http://www.esmo.org/guidelines/gastrointestinal-cancers/hepatocellular-carcinoma hepatocellular carcinoma: esmo-esdo clinical practice guidelines ann oncol 2012; 23 (suppl 7): vii41-vii48.


Other articles:

http://www.petmd.com/dog/conditions/cancer/c_dg_liver_cancer pet md liver cancer (hepatocellular carcinoma) in dogs

http://www.omicsonline.org/open-access/whole-body-computed-tomography-for-tumor-staging-in-dogs-reviewof-16-cases-2157-7579-1000344.php?aid=74493 whole body computed tomography for tumor staging in dogs: review of 16 cases by bonaparte a et al., j veterinar sci technol 7:344. Doi:10.4172/2157-7579.1000344


Related videos:

https://www.youtube.com/watch?v=csen9ldryla hepatocellular carcinoma

https://www.youtube.com/watch?v=wj5esmfj-ri hepatocellular carcinoma

https://www.youtube.com/watch?v=n_sm5cn83ww surgery for primary hepatocellular carcinoma

https://www.youtube.com/watch?v=wrgilayoaxs hepatocellular carcinoma: optimal treatment and transplantation

https://www.youtube.com/watch?v=do3hhzgmqh0 hepatocellular carcinoma

https://www.youtube.com/watch?v=yzjkh3maltk liver cancer, hepatocellular carcinoma, and hepatoma by dr. Robert gish.


Presentations/quiz/newspaper articles:

http://medicalxpress.com/news/2016-06-starving-cancer-cells-blocking-metabolism.html medical xpress starving cancer cells by blocking their metabolism june 14, 2016

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