hemochromatosis
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Hemochromatosis

Hemochromatosis

Last Reviewed : 12/28/2020
Hemochromatosis

Iron overload, also known as hemochromatosis or haemochromatosis, indicates accumulation of iron in the body from any cause. The most important causes are hereditary haemochromatosis (HHC), a genetic disorder, and transfusional iron overload, which can result from repeated blood transfusions.

 

We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.

 

Basic information:

https://www.niddk.nih.gov/health-information/health-topics/liver-disease/hemochromatosis/pages/facts.aspxnationalinstitute of diabetes and digestive and kidney disorders hemochromatosis

http://www.mayoclinic.org/diseases-conditions/hemochromatosis/home/ovc-20167289 mayo clinic hemochromatosis

http://www.webmd.com/a-to-z-guides/hemochromatosis-gene-test-hfe#1 web md hemochromatosis gene test (hfe test)

http://www.healthline.com/health/hemochromatosis health line hemochromatosis

http://www.merckmanuals.com/professional/hematology-and-oncology/iron-overload/hereditary-hemochromatosismerck manuals (professional version) hereditary hemochromatosis

https://labtestsonline.org/understanding/conditions/hemochrom/ lab tests online hemochromatosis

https://www.genome.gov/10001214/learning-about-hereditary-hemochromatosis/ national human genome research institute hemochromatosis

http://my.clevelandclinic.org/health/diseases_conditions/hic_hemochromatosis cleveland clinic hemochromatosis

http://www.nytimes.com/health/guides/disease/hemochromatosis/overview.html newyork times hemochromatosis

http://www.hopkinsmedicine.org/healthlibrary/conditions/adult/digestive_disorders/hemochromatosis_22,hemochromatosis/john hopkins medical library hemochromatosis

https://kidshealth.org/en/parents/hh.html?wt.ac=ctg kids health hemochromatosis

http://umm.edu/health/medical/ency/articles/hemochromatosis university of maryland medical center hemochromatosis

https://www.healthlinkbc.ca/health-topics/hw180388 health link bc hemochromatosis

http://familydoctor.org/familydoctor/en/diseases-conditions/hereditary-hemochromatosis.printerview.all.html family doctor hereditary hemochromatosis

https://www.verywell.com/hypothyroidism-and-iron-anemia-and-hemochromatosis-3231809 very well hypothyroidism and iron: anemia and hemochromatosis

 

Advanced information:

http://emedicine.medscape.com/article/177216-overview medscape hemochromatosis

https://medlineplus.gov/hemochromatosis.html medline plus hemochromatosis

http://www.medicinenet.com/iron_overload/article.htm medicine net.com hereditary hemochromatosis (iron overload)

http://www.medicalnewstoday.com/articles/166455.php medical news today what is iron overload disorder? What is hemochromatosis? What causes iron overload disorder?

http://www.uptodate.com/contents/hemochromatosis-hereditary-iron-overload-beyond-the-basics uptodate patient education: hemochromatosis (hereditary iron overload) (beyo d the basics)

http://chealth.canoe.com/condition/getcondition/iron-overload canoe hemochromatosis

https://www.snpedia.com/index.php/hemochromatosis snpedia hemochromatosis

https://rarediseases.org/rare-diseases/classic-hereditary-hemochromatosis/ national organisation for rare diseases classic hereditary hemochromatosis

http://www.fpnotebook.com/gi/hemeonc/hmchrmts.htm family practise notebook hemochromatosis

http://www.emedicinehealth.com/hemochromatosis_iron_overload/page2_em.htm emedicine health hemochromatosis

http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/hepatology/hemochromatosis/ cleveland clinic hemochromatosis

http://www.aafp.org/afp/2013/0201/p183.html hereditary hemochromatosis brian k. Crownover, md, and carlton j. Covey, md, nellis family medicine residency, nellis air force base, nevada am fam physician. 2013 feb 1;87(3):183-190.

http://www.radio.univ-rennes1.fr/sources/en/hemo.html iron, liver and mri. Yves gandon - medical imaging, rennes, france.

http://patient.info/in/health/haemochromatosis-leaflet patient haemochromatosis

http://appliedradiology.com/articles/hemochromatosis-arthropathy applied radiology hemochromatosis arthropathy

 

Research:

http://www.scielo.br/scielo.php?script=sci_arttext&pid=s0100-879x2005000900005 http://dx.doi.org/10.1590/s0100-879x2005000900005 braz j med biol res, september 2005, volume 38(9) 1321-1324 (short communication) hemochromatosis (hfe) gene mutations in brazilian chronic hemodialysis patients by f.v. Perícole et al.,

http://journal.frontiersin.org/article/10.3389/fnagi.2013.00037/full original research article front. Aging neurosci., 05 august 2013 | http://dx.doi.org/10.3389/fnagi.2013.00037 effects of hemochromatosis and transferrin gene mutations on peripheral iron dyshomeostasis in mild cognitive impairment and alzheimer's and parkinson's diseases by s. Mariani et al.,

https://www.hindawi.com/journals/ah/2009/251701/ gérald le gac, chandran ka, isabelle gourlaouen, et al., “hfe-related hemochromatosis: the haptoglobin 2-2 type has a significant but limited influence on phenotypic expression of the predominant p.c282y homozygous genotype,” advances in hematology, vol. 2009, article id 251701, 6 pages, 2009. Doi:10.1155/2009/251701

http://bmcnephrol.biomedcentral.com/articles/10.1186/1471-2369-14-48 the a736v tmprss6 polymorphism influences hepcidin and iron metabolism in chronic hemodialysis patients: tmprss6 and hepcidin in hemodialysis by serena pelusi et al., bmc nephrology201314:48 doi: 10.1186/1471-2369-14-48

http://bmcmedgenet.biomedcentral.com/articles/10.1186/1471-2350-9-18 snp selection for genes of iron metabolism in a study of genetic modifiers of hemochromatosis by clare c constantine et al., bmc medical genetics20089:18 doi: 10.1186/1471-2350-9-18

http://europepmc.org/backend/ptpmcrender.fcgi?accid=pmc3296740&blobtype=pdf strnad p, kucukoglu o, lunova m, guldiken n, lienau tc, et al. (2012) non-coding keratin variants associate with liver fibrosis progression in patients with hemochromatosis. Plos one 7(3): e32669. Doi:10.1371/journal.pone.0032669

Geetha r l, vani b r, murthy v s, kumar d, geethamala k. Hereditary hemochromatosis in an indian origin: a rare case report. Int j health allied sci [serial online] 2015 [cited 2016 sep 30];4:174-7. Available from: http://www.ijhas.in/text.asp?2015/4/3/174/160894

http://europepmc.org/backend/ptpmcrender.fcgi?accid=pmc3660331&blobtype=pdf kim j, buckett pd, wessling-resnick m (2013) absorption of manganese and iron in a mouse model of hemochromatosis. Plos one 8(5): e64944. Doi:10.1371/journal.pone.0064944

http://europepmc.org/backend/ptpmcrender.fcgi?accid=pmc4425487&blobtype=pdf : dionisio tavares niewiadonski v, dos santos bianchi jv, de almeida-neto c, gaburo n, jr,sabino ec (2015) evaluation of a high throughput method for the detection of mutations associated with thrombosis and hereditary hemochromatosis in brazilian blood donors. Plos one 10(5): e0125460. Doi:10.1371/journal.pone.0125460

http://europepmc.org/backend/ptpmcrender.fcgi?accid=pmc3887013&blobtype=pdf pretorius e, bester j, vermeulen n, lipinski b, gericke gs, et al. (2014) profound morphological changes in the erythrocytes and fibrin networks of patients with hemochromatosis or with hyperferritinemia, and their normalization by iron chelators and other agents. Plos one 9(1): e85271. Doi:10.1371/journal.pone.0085271

http://bmccellbiol.biomedcentral.com/articles/10.1186/1471-2121-8-30 expression of hereditary hemochromatosis c282y hfe protein in hek293 cells activates specific endoplasmic reticulum stress responses by matthew w lawless et al., bmc cell biology20078:30 doi: 10.1186/1471-2121-8-30

http://journal.frontiersin.org/article/10.3389/fphar.2014.00042/full mini review article front. Pharmacol., 11 march 2014 | http://dx.doi.org/10.3389/fphar.2014.00042 molecular basis of hfe-hemochromatosis by maja vujic*

http://clinchem.aaccjnls.org/content/52/6/950 hereditary hemochromatosis: genetic complexity and new diagnostic approaches by dorine w. Swinkels, mirian c.h. Janssen, jürgen bergmans, joannes j.m. Marx doi: 10.1373/clinchem.2006.068684 published may 2006

 

Other helpful resources(support groups):

http://www.hemochromatosis.org/#overview hemochromatosis.org

http://www.americanhs.org/ american hemochromatosis society

http://www.liverfoundation.org/abouttheliver/info/hemochromatosis/ american liver foundation

http://www.toomuchiron.ca/ canadian hemochromatosis society

 

Related videos:

https://www.youtube.com/watch?v=uerr-s2awry what is hemochromatosis?

https://www.youtube.com/watch?v=-dawfzd8y6o hemochromatosis made easy for usmle

https://www.youtube.com/watch?v=iuga3om65bc hemochromatosis - definition & pathology

https://www.youtube.com/watch?v=zyr6l7r2c2m hemochromatosis symptoms, causes, and treatment

https://www.youtube.com/watch?v=da0wlfdzega hemochromatosis - a deadly disease, pp

 

Presentations/quiz/newspaper articles:

http://www.the-scientist.com/?articles.view/articleno/19796/title/hemochromatosis-and-diabetes/ the scientist hemochromatosis and diabetes

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