Guillian barre syndrome(gbs)

Guillian barre syndrome(gbs)

Last Reviewed : 12/28/2020
Guillian barre syndrome(gbs)

Guillain–Barre syndrome (GBS) is a rapid-onset muscle weakness caused by the immune system damaging the peripheral nervous system. Many experience changes in sensation or develop pain, followed by muscle weakness beginning in the feet and hands. The symptoms develop over half a day to two weeks. During the acute phase, the disorder can be life-threatening with about a quarter developing weakness of the breathing muscles and requiring mechanical ventilation. Some are affected by changes in the function of the autonomic nervous system, which can lead to dangerous abnormalities in heart rate and blood pressure.

This autoimmune disease is caused by the body's immune system mistakenly attacking the peripheral nerves and damaging their myelin insulation. Sometimes this immune dysfunction is triggered by an infection. The diagnosis is usually made based on the signs and symptoms, through the exclusion of alternative causes, and supported by tests such as nerve conduction studies and examination of the cerebrospinal fluid. Various classifications exist, depending on the areas of weakness, results of nerve conduction studies, and the presence of antiganglioside antibodies. It is classified as an acute polyneuropathy.

In those with severe weakness, prompt treatment with intravenous immunoglobulins or plasmapheresis, together with supportive care, will lead to good recovery in the majority. Some may experience ongoing difficulty with walking, painful symptoms, and some require long-term breathing support. Guillain–Barré syndrome is rare, at one to two cases per 100,000 people every year. The syndrome is named after the French neurologists Georges Guillain and Jean Alexandre Barré, who described it with André Strohl in 1916.


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Basic information: health line guillain-barre syndrome mayo clinic guillain-barre syndrome national institute of neurological disorders and stroke guillain-barre syndrome nhs uk guillain-barré syndrome who fact sheet guillain-barre syndrome web md guillain-barré syndrome - topic overview medicine guillain-barré syndrome better health guillain-barre syndrome new york times guillain-barre syndrome kids health guillain-barre syndrome emedicine health guillain-barre syndrome guillain-barre syndrome health direct guillain-barre syndrome brain foundation guillain-barre syndrome every day health guillain-barre syndrome university of maryland guillain-barre syndrome life in the fast lane guillain-barre syndrome merck manuals guillain-barre syndrome my health guillain-barre syndrome clevland clinic guillain-barre syndrome


Advanced information: medscape guillain-barre syndrome mnt guillain-barre syndrome: causes, diagnosis and treatment patient guillain-barre syndrome zika virus and guillain-barré syndrome nord guillain-barre syndrome

The lancet. "zika virus might cause guillain-barré syndrome, according to new evidence." sciencedaily. Sciencedaily, 1 march 2016. radiopedia guillain-barre syndrome guillain-barré syndrome dana l. Newswanger, lcdr, mc, usnr, national naval medical center, bethesda, maryland,charles r. Warren, lcdr, mc, usnr, naval hospital jacksonville, jacksonville, florida am fam physician. 2004 may 15;69(10):2405-2410. family practise notebook guillain-barre syndrome physiopedia guillain-barre syndrome britannica guillain-barre syndrome


Research: guillain-barré syndrome outbreak associated with zika virus infection in french polynesia: a case-control study by van-mai cao-lormeau, phd the lancet volume 387, no. 10027, p1531–1539, 9 april 2016 doi: eurosurveillance, volume 19, issue 9, 06 march 2014 rapid communications zika virus infection complicated by guillain-barré syndrome – case report, french polynesia, december 2013 by e oehle et al., zika virus infection could trigger guillain–barré syndrome by hemi malkki nature reviews neurology 12,187(2016)doi:10.1038/nrneurol.2016.30 ganglioside molecular mimicry and its pathological roles in guillain-barré syndrome and related diseases by robert k. Yu*, seigo usuki and toshio ariga doi: 10.1128/iai.00967-06infect. Immun. December 2006vol. 74 no. 12 6517-6527 practice parameter: immunotherapy for guillain–barré syndrome report of the quality standards subcommittee of the american academy of neurology by r.a.c. Hughes, md et al., arq. Neuro-psiquiatr. Vol.62 no.1 são paulo mar. 2004 epidemiologic features of guillain-barré syndrome in são paulo, brazil by maria sheila guimarães rocha et al., understanding guillain-barré syndrome by estridge et al., journal of the american academy of physician assistants:july 2015 - volume 28 - issue 7 - p 19–22 doi: 10.1097/01.jaa.0000466585.10595.f5 cme: neurology campylobacter species and guillain-barre´ syndrome by irving nachamkin et al., clinical microbiology reviews, july 1998, p. 555–567 vol. 11, no. 3 guillain–barré syndrome following primary cytomegalovirus infection: a prospective cohort study by david orlikowski et al., clin infect dis. (2011) 52 (7):837-844.doi: 10.1093/cid/cir074 influenza vaccination and guillain barre syndrome by mark r. Geier et al., clinical immunology 107 (2003) 116–121 guillain-barré syndrome presenting with raynaud's phenomenon: a case report by sonali sihindi chapa gunatilake and harith wimalaratna bmc neurologybmc series ¿ open, inclusive and trusted201414:174 doi: 10.1186/s12883-014-0174-3 miller fisher variant of guillain-barre´ syndrome: a report of case by matthew p. Kozminski, do the journal of the american osteopathic association, february 2008, vol. 108, 51-52. guillain-barré syndrome and acute hepatitis e : a rare association by rajesh kumar et al., jiacm 2002; 3(4): 389-91 mediators of inflammation
volume 2015 (2015), article id 564098, 12 pages review article:biomarkers of guillain-barré syndrome: some recent progress, more still to be explored by ying wang et al.,

Ram s. India's contribution on "guillain-barre syndrome": mapping of 40 years research. Neurol india [serial online] 2013 [cited 2016 jun 12];61:375-82. Available from:


Other helpful resources(support groups): guillian barre support group nz trust


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Presentations/quiz/newspaper articles: cbs news zika virus raises new worry about paralysis bbc news study shows zika 'might cause' guillain-barré syndrome independent guillain-barré syndrome: the other deadly disease lurking in zika mosquitoes los angeles times zika's link to guillain-barre syndrome revealed

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