Goodpasture syndrome is an autoimmune disorder that affects both kidneys and lungs. In this condition, body mistakenly produces antibodies against collagen present in lungs and kidneys resulting in signs and symptoms related to both these organs. It is also called anti-GBM (anti-glomerulo-basement-membrane) disease. Exact cause is unknown. Symptoms include fatigue, weakness, difficulty in breathing, blood in the urine, foamy urine, swellings in the legs and high blood pressure. It is usually diagnosed by blood tests, kidney ultrasound, chest XR and kidney biopsy. Kidney biopsy or lung biopsy confirms the diagnosis. Treatment includes steroids and chemotherapy agents like cyclophosphamide.
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http://jasn.asnjournals.org/content/8/11/1795.full.pdf. Journal of the american society of nephrology. Goodpasture syndrome involving overlap with wegener’s granulomatosis and anti-glomerular basement membrane disease raghu kalluri, kevin meyers, andras mogyorosi, michael p. Madaio, and eric 0. Neilson