gene-therapy
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Gene therapy

Gene therapy

Last Reviewed : 12/25/2020
Gene therapy

Gene therapy is the therapeutic delivery of nucleic acid polymers into a patient's cells as a drug to treat disease.

The first attempt at modifying human DNA was performed in 1980 by Martin Cline, but the first successful and approved nuclear gene transfer in humans was performed in May 1989. The first therapeutic use of gene transfer as well as the first direct insertion of human DNA into the nuclear genome was performed by French Anderson in a trial starting in September 1990.

Between 1989 and February 2016, over 2,300 clinical trials had been conducted, more than half of them in phase I.

It should be noted that not all medical procedures that introduce alterations to a patient's genetic makeup can be considered gene therapy. Bone marrow transplantation and organ transplants in general have been found to introduce foreign DNA into patients. Gene therapy is defined by the precision of the procedure and the intention of direct therapeutic effects.

 

We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.

 

Basic information:

https://ghr.nlm.nih.gov/primer/therapy/genetherapy genetics home reference what is gene therapy?

http://www.mayoclinic.org/tests-procedures/gene-therapy/home/ovc-20243692 mayo clinic overview

http://www.yourgenome.org/facts/what-is-gene-therapy your genome what is gene therapy?

http://www.news-medical.net/health/what-is-gene-therapy.aspx news medical what is gene therapy?

https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/gene-therapy better health gene therapy

http://kidshealth.org/en/parents/gene-therapy.html kids health gene therapy

https://www.verywell.com/what-is-gene-therapy-2860733 very well what is gene therapy?

 

Advanced information:

https://www.sciencedaily.com/terms/gene_therapy.htm science daily gene therapy

http://www.medicinenet.com/script/main/art.asp?articlekey=12662 medicine net gene therapy - the future is here!

http://patient.info/doctor/gene-therapy patient gene therapy

 

Research:

http://www.scielo.br/scielo.php?script=sci_arttext&pid=s0100-879x2011001100004&lng=en&tlng=enhttp://dx.doi.org/10.1590/s0100-879x2011007500123 braz j med biol res, november 2011, volume 44(11) 1097-1104 adeno-associated virus for cystic fibrosis gene therapy by s.v. Martini et al.,

http://maxwellsci.com/jp/abstract.php?jid=crjbs&no=169&abs=16 jabar zaman khan khattak, sobiah rauf, zubair anwar, hussain mustatab wahedi and talal jamil, 2012. Recent advances in genetic engineering - a review. Current research journal of biological sciences, 4(1): 82-89.

https://f1000research.com/articles/5-2105/v1 bilsland ae, spiliopoulou p and evans trj. Virotherapy: cancer gene therapy at last? [version 1; referees: 2 approved]. F1000research 2016, 5(f1000 faculty rev):2105 (doi: 10.12688/f1000research.8211.1)

https://www.hindawi.com/journals/prt/2011/968218/ yu huang, xin liu, lanlan dong, zhongchun liu, xiaohua he, and wanhong liu, “development of viral vectors for gene therapy for chronic pain,” pain research and treatment, vol. 2011, article id 968218, 8 pages, 2011. Doi:10.1155/2011/968218

http://err.ersjournals.com/content/22/127/58.full.pdf+html targeting a genetic defect: cystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis by nico derichs et al., european respiratory review 2013 22: 58-65; doi: 10.1183/09059180.00008412

Bali a, bali d, sharma a. An overview of gene therapy in head and neck cancer. Indian j hum genet [serial online] 2013 [cited 2016 sep 29];19:282-90. Available from: http://www.ijhg.com/text.asp?2013/19/3/282/120811

https://www.hindawi.com/journals/ijad/2011/517160/ tarja malm, jari koistinaho, and katja kanninen, “utilization of appswe/ps1de9 transgenic mice in research of alzheimer's disease: focus on gene therapy and cell-based therapy applications,” international journal of alzheimer’s disease, vol. 2011, article id 517160, 8 pages, 2011. Doi:10.4061/2011/517160

http://hmg.oxfordjournals.org/content/11/20/2355.full gene therapy of muscular dystrophy hum. Mol. Genet. (2002) 11 (20):2355-2362.doi: 10.1093/hmg/11.20.2355

http://rspb.royalsocietypublishing.org/content/282/1821/20143003 gene therapy: progress and predictions by mary collins, adrian thrasher published 23 december 2015.doi: 10.1098/rspb.2014.3003

 

Other helpful resources(support groups):

http://www.asgct.org/general-public/educational-resources/gene-therapy--and-cell-therapy-defined american society of gene and cell therapy

http://www.acgtfoundation.org/ alliance for cancer gene therapy

 

Related videos:

https://www.youtube.com/watch?v=u3rygvusrok gene therapy, a new tool to cure human diseases

https://www.youtube.com/watch?v=se7fi8jm8ho gene therapy part 1 : basics of gene therapy

https://www.youtube.com/watch?v=znzvsnbkrqs gene therapy

https://www.youtube.com/watch?v=21nx9drtp18 gene therapy using retrovirus vector

https://www.youtube.com/watch?v=ctgbicykdls human gene therapy, types of gene therapy part 1

https://www.youtube.com/watch?v=darvrk0y_li human gene therapy, types of gene therapy part 2

https://www.youtube.com/watch?v=mpysddayhrq human gene therapy, types of gene therapy part 3

https://www.youtube.com/watch?v=hgs0_1vzyxu human gene therapy, types of gene therapy part 4

 

Presentations/quiz/newspaper articles:

https://www.theguardian.com/society/2016/oct/01/final-push-to-end-sickle-cell-anaemia the guardian gene therapy offers hope for treatment of sickle cell anaemia

https://www.scientificamerican.com/article/experts-gene-therapy/ scientific american how does gene therapy work?

https://www.wired.com/2013/08/the-fall-and-rise-of-gene-therapy-2/ wired gene therapy emerges from disgrace to be the next big thing, again

https://www.washingtonpost.com/business/economy/gene-therapies-offer-dramatic-promise-but-shocking-costs/2015/11/11/01f11cf0-824b-11e5-9afb-0c971f713d0c_story.html washington post gene therapies offer dramatic promise but shocking costs

http://www.bbc.com/news/science-environment-36101786 bbc news gene therapy reverses sight loss and is long-lasting

https://www.statnews.com/2015/12/31/crispr-mice-duchenne/ stat news gene therapy treats duchenne muscular dystrophy in mice

http://www.economist.com/blogs/economist-explains/2016/08/economist-explains-2 economist why gene-therapy drugs are so expensive

http://timesofindia.indiatimes.com/city/bengaluru/bangalore-turns-to-gene-therapy/articleshow/8229297.cms times of india bangalore turns to gene therapy

http://www.reuters.com/article/us-health-genetherapy-gsk-iduskcn0wy4xf reuters europe gives green light to first gene therapy for children

http://www.cbc.ca/news/canada/windsor/felix-quiring-immune-disorder-1.3739966 cc news l.a. Gene therapy restores leamington, ont., boy's immune system

https://www.newscientist.com/article/dn28047-gene-therapy-cures-blindness-by-replacing-vision-cells-in-eyes/ news scientist gene therapy cures blindness by replacing vision cells in eyes

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