gastro-intestinal-stromal-tumor
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Gastro intestinal stromal tumor

Gastro intestinal stromal tumor

Last Reviewed : 12/28/2020

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. GISTs arise in the smooth muscle pacemaker interstitial cell of Cajal, or similar cells. They are defined as tumors whose behavior is driven by mutations in the KIT gene (85%),PDGFRA gene (10%), or BRAF kinase (rare). 95% of GISTs stain positively for KIT (CD117). Most (66%) occur in the stomach and gastric GISTs have a lower malignant potential than tumors found elsewhere in the GI tract.

 

We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.

 

Basic information:

http://www.cancerresearchuk.org/about-cancer/cancers-in-general/cancer-questions/what-is-the-treatment-for-gist-gastrointestinal-stromal-tumour cancer research uk gastrointestinal stromal tumor

http://www.webmd.com/cancer/gastrointestinal-stromal-tumors web md gastrointestinal stromal tumor

http://www.msdmanuals.com/professional/gastrointestinal-disorders/tumors-of-the-gi-tract/gastrointestinal-stromal-tumors msd manuals (professional version) gastrointestinal stromal tumor

http://www.medicinenet.com/script/main/art.asp?articlekey=23038 medicine net.com gastrointestinal stromal tumor

https://liferaftgroup.org/understanding-gist / the life raft group understanding gist

http://www.healthline.com/health/gist/how-are-gastrointestinal-stromal-tumors-diagnosed-and-treated health line how are gastrointestinal stromal tumors diagnosed and treated?

 

Advanced information:

http://emedicine.medscape.com/article/179669-overview medscape gastrointestinal stromal tumors

https://ghr.nlm.nih.gov/condition/gastrointestinal-stromal-tumor#genes genetics home reference gastrointestinal stromal tumor

http://patient.info/doctor/gastrointestinal-stromal-tumours patient gastrointestinal stromal tumor

http://radiopaedia.org/articles/gastrointestinal-stromal-tumour-1 radiopedia gastrointestinal stromal tumor

http://rarediseases.org/rare-diseases/gastrointestinal-stromal-tumors/ national organisation of rare diseases gastrointestinal stromal tumor

http://www.uptodate.com/contents/adjuvant-and-neoadjuvant-imatinib-for-gastrointestinal-stromal-tumors upto date adjuvant and neoadjuvant imatinib for gastrointestinal stromal tumors

https://www.oncolink.org/resources/nci.cfm?id=cdr0000658500 oncolink gastrointestinal stromal tumor

http://www.augis.org/wp-content/uploads/2014/05/gist_management_guidelines_180809.pdf guidelines for the management of gastrointestinal stromal tumours (gist)

 

Research:

http://wjso.biomedcentral.com/articles/10.1186/1477-7819-8-90 gist suture-line recurrence at a gastrojejunal anastomosis 8 years after gastrectomy: can gist ever be described as truly benign? A case report by alexandros papalambros et al., world journal of surgical oncology20108:90 doi: 10.1186/1477-7819-8-90

http://www.scopemed.org/fulltextpdf.php?mno=201307 upper gastro-intestinal bleeding in the young - gastric gist tumor or peptic ulcer disease? By ayodele atolagbe,rahaman oloruntobi, adeyemi ogunleye and chukwuemeka apakama ayodele atolagbe et al./ international journal of surgery and medicine (2015) 1(2); 72-75

http://www.doiserbia.nb.rs/img/doi/0370-8179/2016/0370-81791604219c.pdf a massive bleeding from a gastrointestinal stromal tumor of a meckel’s diverticulum by mariusz chabowski et al., srp arh celok lek. 2016 mar-apr;144(3-4):219-221 doi: 10.2298/sarh1604219c

Rajekar h, bhoje a, vaiphei k. Rectal adenocarcinoma coexisting with gastro-intestinal stromal tumor: a case report and literature review. J can res ther [serial online] 2013 [cited 2016 jun 10];9:138-40. Available from: http://www.cancerjournal.net/text.asp?2013/9/1/138/110379

http://www.jemds.com/data_pdf/1_anand.pdf gastrointestinal stromal tumour – revisited by aparana acharya, anand achayra journal of evolution of medical and dental sciences/ volume 2/ issue 12/ march 25, 2013

http://www.sciencedirect.com/science/article/pii/s221026121500036x unique case of sporadic multiple gastro intestinal stromal tumour by luigina graziosi et al., international journal of surgery case reports volume 9, 2015, pages 98–100 doi:10.1016/j.ijscr.2015.01.025

http://wjso.biomedcentral.com/articles/10.1186/1477-7819-6-55 port site metastasis following diagnostic laparoscopy for a malignant gastro-intestinal stromal tumour by andrew r davies et al., world journal of surgical oncology20086:55 doi: 10.1186/1477-7819-6-55

Ravikumar g, kalegowda i y, ananthamurthy a. Clinicopathologic spectrum of gastro intestinal stromal tumours - experience at a tertiary care center. Indian j cancer [serial online] 2011 [cited 2016 jun 10];48:466-70. Available from: http://www.indianjcancer.com/text.asp?2011/48/4/466/92281

Divakaran j, chander b. Primary extra-gastrointestinal stromal tumor of the omentum. J can res ther [serial online] 2012 [cited 2016 jun 10];8:433-5. Available from: http://www.cancerjournal.net/text.asp?2012/8/3/433/103527

http://www.nejm.org/doi/full/10.1056/nejmoa020461#t=article efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors by george d. Demetri, m.d. Et al., n engl j med 2002; 347:472-480august 15, 2002doi: 10.1056/nejmoa020461

http://www.nature.com/modpathol/journal/v27/n1s/full/modpathol2013173a.html modern pathology (2014) 27, s1–s16; doi:10.1038/modpathol.2013.173 gastrointestinal stromal tumors: what do we know now? By christopher l corless.

http://annonc.oxfordjournals.org/content/23/suppl_7/vii49.full gastrointestinal stromal tumors: esmo clinical practice guidelines for diagnosis, treatment and follow-up by the esmo / european sarcoma network working group oxford journals,medicine & health,annals of oncology,volume 23, issue suppl 7,pp. Vii49-vii55

http://pubs.rsna.org/doi/full/10.1148/rg.262055097 gastrointestinal stromal tumor: role of ct in diagnosis and in response evaluation and surveillance after treatment with imatinib by xie hong, md, phd et al., march-april 2006 volume 26, issue 2

http://www.sciencedirect.com/science/article/pii/s1743919112007649 duodenal gastrointestinal stromal tumors: review on clinical and surgical aspects by g. Cavallaro et al., international journal of surgery volume 10, issue 9, 2012, pages 463–465 doi:10.1016/j.ijsu.2012.08.015

http://onlinelibrary.wiley.com/doi/10.1002/cncr.9042/pdf cytologic diagnosis of gastrointestinal stromal tumor with emphasis on the differential diagnosis with leiomyosarcoma by tad j. Wieczorek, m.d et al., cancer cytopathologyvolume 93, issue 4, version of record online: 10 aug 2001

https://wjso.biomedcentral.com/articles/10.1186/1477-7819-6-97 gastrointestinal stromal tumor of the stomach with lymph node metastasis by aras emre canda et al., world journal of surgical oncology20086:97 doi: 10.1186/1477-7819-6-97

http://www.scielo.br/scielo.php?script=sci_arttext&pid=s0004-28032009000200008 arq. Gastroenterol. Vol.46 no.2 são paulo apr./june 2009 http://dx.doi.org/10.1590/s0004-28032009000200008 artigo original original article ki67 and p53 in gastrointestinal stromal tumors – gist by lúcio roberto de oliveira das neves et al.,

http://springerplus.springeropen.com/articles/10.1186/s40064-015-0850-9 laparoscopic resection of a rare gastrointestinal stromal tumor in children by mario lima et al.,springerplus20154:73 doi: 10.1186/s40064-015-0850-9

http://www.specialap.unimi.it/pict/deitos.pdf gastrointestinal stromal tumors: the histology report by angelo p. Dei tos et al., digestive and liver disease 43s (2011) s304–s309

http://theoncologist.alphamedpress.org/content/13/suppl_2/4.full response evaluation of gastrointestinal stromal tumors by doi: 10.1634/theoncologist.13-s2-4the oncologist april 2008 vol. 13 supplement 2 4-7

 

Other helpful resources(support groups):

http://www.gistsupport.org/about-gist/what-is-gist.php gist support international

http://www.gistsupportuk.com/ gist support uk

 

Related videos:

https://www.youtube.com/watch?v=_z9ai029qem gastric gastrointestinal stromal tumor

https://www.youtube.com/watch?v=b8picinh1bw gastrointestinal stromal tumor

https://www.youtube.com/watch?v=qvcki758pz0 what is a gist tumor

https://www.youtube.com/watch?v=us4zsbte6ii gastrointestinal stromal tumor

https://www.youtube.com/watch?v=os7gmdkuxwa surgical oncology for gastrointestinal stromal tumors (gist): ask dr. Waddah al-refaie

https://www.youtube.com/watch?v=q_nx653sd20 gastrointestinal stromal tumor metastatic to liver: role of interventional radiology

https://www.youtube.com/watch?v=0pyjz5bjmru pre-operative evalution of gastric gastrointestinal stromal tumors: endoscopic ultrasound vs ct scan

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