Gastro intestinal stromal tumor

Gastro intestinal stromal tumor

Last Reviewed : 12/28/2020

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. GISTs arise in the smooth muscle pacemaker interstitial cell of Cajal, or similar cells. They are defined as tumors whose behavior is driven by mutations in the KIT gene (85%),PDGFRA gene (10%), or BRAF kinase (rare). 95% of GISTs stain positively for KIT (CD117). Most (66%) occur in the stomach and gastric GISTs have a lower malignant potential than tumors found elsewhere in the GI tract.


We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.


Basic information: cancer research uk gastrointestinal stromal tumor web md gastrointestinal stromal tumor msd manuals (professional version) gastrointestinal stromal tumor medicine gastrointestinal stromal tumor / the life raft group understanding gist health line how are gastrointestinal stromal tumors diagnosed and treated?


Advanced information: medscape gastrointestinal stromal tumors genetics home reference gastrointestinal stromal tumor patient gastrointestinal stromal tumor radiopedia gastrointestinal stromal tumor national organisation of rare diseases gastrointestinal stromal tumor upto date adjuvant and neoadjuvant imatinib for gastrointestinal stromal tumors oncolink gastrointestinal stromal tumor guidelines for the management of gastrointestinal stromal tumours (gist)


Research: gist suture-line recurrence at a gastrojejunal anastomosis 8 years after gastrectomy: can gist ever be described as truly benign? A case report by alexandros papalambros et al., world journal of surgical oncology20108:90 doi: 10.1186/1477-7819-8-90 upper gastro-intestinal bleeding in the young - gastric gist tumor or peptic ulcer disease? By ayodele atolagbe,rahaman oloruntobi, adeyemi ogunleye and chukwuemeka apakama ayodele atolagbe et al./ international journal of surgery and medicine (2015) 1(2); 72-75 a massive bleeding from a gastrointestinal stromal tumor of a meckel’s diverticulum by mariusz chabowski et al., srp arh celok lek. 2016 mar-apr;144(3-4):219-221 doi: 10.2298/sarh1604219c

Rajekar h, bhoje a, vaiphei k. Rectal adenocarcinoma coexisting with gastro-intestinal stromal tumor: a case report and literature review. J can res ther [serial online] 2013 [cited 2016 jun 10];9:138-40. Available from: gastrointestinal stromal tumour – revisited by aparana acharya, anand achayra journal of evolution of medical and dental sciences/ volume 2/ issue 12/ march 25, 2013 unique case of sporadic multiple gastro intestinal stromal tumour by luigina graziosi et al., international journal of surgery case reports volume 9, 2015, pages 98–100 doi:10.1016/j.ijscr.2015.01.025 port site metastasis following diagnostic laparoscopy for a malignant gastro-intestinal stromal tumour by andrew r davies et al., world journal of surgical oncology20086:55 doi: 10.1186/1477-7819-6-55

Ravikumar g, kalegowda i y, ananthamurthy a. Clinicopathologic spectrum of gastro intestinal stromal tumours - experience at a tertiary care center. Indian j cancer [serial online] 2011 [cited 2016 jun 10];48:466-70. Available from:

Divakaran j, chander b. Primary extra-gastrointestinal stromal tumor of the omentum. J can res ther [serial online] 2012 [cited 2016 jun 10];8:433-5. Available from: efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors by george d. Demetri, m.d. Et al., n engl j med 2002; 347:472-480august 15, 2002doi: 10.1056/nejmoa020461 modern pathology (2014) 27, s1–s16; doi:10.1038/modpathol.2013.173 gastrointestinal stromal tumors: what do we know now? By christopher l corless. gastrointestinal stromal tumors: esmo clinical practice guidelines for diagnosis, treatment and follow-up by the esmo / european sarcoma network working group oxford journals,medicine & health,annals of oncology,volume 23, issue suppl 7,pp. Vii49-vii55 gastrointestinal stromal tumor: role of ct in diagnosis and in response evaluation and surveillance after treatment with imatinib by xie hong, md, phd et al., march-april 2006 volume 26, issue 2 duodenal gastrointestinal stromal tumors: review on clinical and surgical aspects by g. Cavallaro et al., international journal of surgery volume 10, issue 9, 2012, pages 463–465 doi:10.1016/j.ijsu.2012.08.015 cytologic diagnosis of gastrointestinal stromal tumor with emphasis on the differential diagnosis with leiomyosarcoma by tad j. Wieczorek, m.d et al., cancer cytopathologyvolume 93, issue 4, version of record online: 10 aug 2001 gastrointestinal stromal tumor of the stomach with lymph node metastasis by aras emre canda et al., world journal of surgical oncology20086:97 doi: 10.1186/1477-7819-6-97 arq. Gastroenterol. Vol.46 no.2 são paulo apr./june 2009 artigo original original article ki67 and p53 in gastrointestinal stromal tumors – gist by lúcio roberto de oliveira das neves et al., laparoscopic resection of a rare gastrointestinal stromal tumor in children by mario lima et al.,springerplus20154:73 doi: 10.1186/s40064-015-0850-9 gastrointestinal stromal tumors: the histology report by angelo p. Dei tos et al., digestive and liver disease 43s (2011) s304–s309 response evaluation of gastrointestinal stromal tumors by doi: 10.1634/theoncologist.13-s2-4the oncologist april 2008 vol. 13 supplement 2 4-7


Other helpful resources(support groups): gist support international gist support uk


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