Adenomatous Polyposis Of The Colon (APC)/Familial Multiple Polyposis/FAP/Hereditary Polyposis Coli/Multiple Polyposis Of The Colon
Familial adenomatous polyposis (FAP) is an inherited condition in which numerous adenomatous polyps form mainly in the epithelium of the large intestine. While these polyps start out benign, malignant transformation into colon cancer occurs when they are left untreated. Three variants are known to exist, FAP and attenuated FAP (originally called “hereditary flat adenoma syndrome) are caused by APC gene defects on chromosome 5 while autosomal recessive FAP (or MYH-associated polyposis) is caused by defects in the MUTYH gene on chromosome 1. Of the three, FAP itself is the most severe and most common; although for all three, the resulting colonic polyps and cancers are confined to the colon wall and removal can greatly reduce the spread of cancer.
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Chikkamuniyappa s, jagirdar j. Cribriform-morular variant of papillary carcinoma: association with familial adenomatous polyposis - report of three cases and review of literature. Int j med sci 2004; 1(1):43-49. Doi:10.7150/ijms.1.43. Available from http://www.medsci.org/v01p0043.htm
http://www.jemds.com/data_pdf/1_sandhya---.pdf sushmitha m. G, sandhya i, gowri metkar, aravind p, zulfikar ahmed, vinitha, shreya hegde. “gastrointestinal malignancies: getting a decade younger?”. Journal of evolution of medical and dental sciences 2014; vol. 3,issue 25, june 23; page: 7073-7081, doi: 10.14260/jemds/2014/2861
Punatar sb, noronha v, joshi a, prabhash k. Thyroid cancer in gardner's syndrome: case report and review of literature. South asian j cancer [serial online] 2012 [cited 2016 jun 10];1:43-7. Available from: http://journal.sajc.org/text.asp?2012/1/1/43/96510