familial-adenomatous-polyposis
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Familial adenomatous polyposis

Familial adenomatous polyposis

Last Reviewed : 12/25/2020

SYNONYMS:

Adenomatous Polyposis Of The Colon (APC)/Familial Multiple Polyposis/FAP/Hereditary Polyposis Coli/Multiple Polyposis Of The Colon

Familial adenomatous polyposis (FAP) is an inherited condition in which numerous adenomatous polyps form mainly in the epithelium of the large intestine. While these polyps start out benign, malignant transformation into colon cancer occurs when they are left untreated. Three variants are known to exist, FAP and attenuated FAP (originally called “hereditary flat adenoma syndrome) are caused by APC gene defects on chromosome 5 while autosomal recessive FAP (or MYH-associated polyposis) is caused by defects in the MUTYH gene on chromosome 1. Of the three, FAP itself is the most severe and most common; although for all three, the resulting colonic polyps and cancers are confined to the colon wall and removal can greatly reduce the spread of cancer.

 

We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.

 

Basic information:

http://www.cancer.net/cancer-types/familial-adenomatous-polyposis cancer.net familial adenomatous polyposis

http://www.mayoclinic.org/diseases-conditions/familial-adenomatous-polyposis/basics/definition/con-20035680 mayo clinic familial adenomatous polyposis (fap) definition

http://my.clevelandclinic.org/health/diseases_conditions/hic-colorectal-cancer/familial-adenomatous-polyposis clevland clinic familial adenomatous polyposis (fap)

http://www.macmillan.org.uk/information-and-support/diagnosing/causes-and-risk-factors/genetic-testing-and-counselling/fap.html macmillan foundation familial adenomatous polyposis (fap)

http://rarediseases.org/rare-diseases/familial-adenomatous-polyposis/ nord familial adenomatous polyposis (fap)

http://www.netdoctor.co.uk/conditions/digestive-health/a4923/familial-polyposis-coli-familial-adenomatous-polyposis-or-fap/ net doctor.co familial adenomatous polyposis (fap)

http://www.medicinenet.com/gardner_syndrome/article.htm medicine net.com familial adenomatous polyposis (fap)

http://www.webmd.com/digestive-disorders/familial-adenomatous-polyposis web md familial adenomatous polyposis (fap)

http://www.msdmanuals.com/professional/gastrointestinal-disorders/tumors-of-the-gi-tract/familial-adenomatous-polyposis msd manuals(professional version) familial adenomatous polyposis (fap)

http://www.healthline.com/health/gardners-syndrome health line gardner's syndrome

https://stanfordhealthcare.org/medical-conditions/cancer/fap.html stanford health care familial adenomatous polyposis (fap)

https://www.urmc.rochester.edu/encyclopedia/content.aspx%3fcontenttypeid%3d85%26contentid%3dp07199 university of rochester hereditary colorectal cancer syndromes: familial adenomatous polyposis (fap)

https://www.symptoma.com/en/info/familial-adenomatous-polyposis symptoma familial adenomatous polyposis

https://myhealth.alberta.ca/health/pages/conditions.aspx?hwid=tv7690& my health.alberta.ca familial adenomatous polyposis (fap)

 

Advanced information:

https://ghr.nlm.nih.gov/condition/familial-adenomatous-polyposis#inheritance genetic home reference familial adenomatous polyposis (fap)

http://emedicine.medscape.com/article/175377-overview medscape familial adenomatous polyposis (fap) overview

http://patient.info/doctor/bowel-colonic-polyps-pro patient bowel (colonic) polyps

http://www.orpha.net/consor/cgi-bin/oc_exp.php?lng=gb&expert=733 orpha net familial adenomatous polyposis (fap)

http://genefacts.org/index.php?option=com_content&view=article&id=602&itemid=751 gene facts diagnosis

http://radiopaedia.org/articles/familial-adenomatous-polyposis-syndrome radiopedia familial adenomatous polyposis (fap)

http://insight-group.org/pdf/fap-guidelines.pdf guidelines for the clinical management of familial adenomatous polyposis (fap) by h f a vasen et al., gut 2008;57:704–713. Doi:10.1136/gut.2007.136127

https://www.genomicseducation.hee.nhs.uk/resources/genetic-conditions-factsheets/item/76-familial-adenomatous-polyposis genomics education familial adenomatous polyposis (fap)

http://www.uhs.nhs.uk/media/controlleddocuments/patientinformation/genetics/familial-adenomatous-polyposis-fap-leaflet.pdf university hospital southampton familial adenomatous polyposis (fap)

http://www.cancer.ie/cancer-information/bowel-colon-rectum-cancer/causes-prevention/familial-adenomatous-polyposis#sthash.ujve9v74.dpbs irish cancer society familial adenomatous polyposis (fap)

http://www.britannica.com/topic/familial-adenomatous-polyposis encyclopedia britannica familial adenomatous polyposis (fap)

https://www.northwell.edu/find-care/conditions-we-treat/familial-adenomatous-polyposis north well education familial adenomatous polyposis (fap)

 

Research:

Chikkamuniyappa s, jagirdar j. Cribriform-morular variant of papillary carcinoma: association with familial adenomatous polyposis - report of three cases and review of literature. Int j med sci 2004; 1(1):43-49. Doi:10.7150/ijms.1.43. Available from http://www.medsci.org/v01p0043.htm

http://www.ebiomedicine.com/article/s2352-3964(15)00086-9/fulltext aspirin prevents colorectal cancer by normalizing egfr expression by li, haitao et al.ebiomedicine , volume 2 , issue 5 , 447 – 455 doi: http://dx.doi.org/10.1016/j.ebiom.2015.03.019

http://www.jemds.com/data_pdf/1_sandhya---.pdf sushmitha m. G, sandhya i, gowri metkar, aravind p, zulfikar ahmed, vinitha, shreya hegde. “gastrointestinal malignancies: getting a decade younger?”. Journal of evolution of medical and dental sciences 2014; vol. 3,issue 25, june 23; page: 7073-7081, doi: 10.14260/jemds/2014/2861

http://hccpjournal.biomedcentral.com/articles/10.1186/1897-4287-9-5 drug therapy for hereditary cancers by evgeny n imyanitov and vladimir m moiseyenko hereditary cancer in clinical practice20119:5 doi: 10.1186/1897-4287-9-5

http://hccpjournal.biomedcentral.com/articles/10.1186/1897-4287-8-3 surveillance of fap: a prospective blinded comparison of capsule endoscopy and other gi imaging to detect small bowel polyps by paul tescher et al., hereditary cancer in clinical practice20108:3 doi: 10.1186/1897-4287-8-3

http://hccpjournal.biomedcentral.com/articles/10.1186/1897-4287-2-2-81 germline missense changes in the apc gene and their relationship to disease by rodney j scott et al., hereditary cancer in clinical practice20042:81 doi: 10.1186/1897-4287-2-2-81

http://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-2-41 role of apc and dna mismatch repair genes in the development of colorectal cancers by satya narayan and deodutta roy molecular cancer20032:41 doi: 10.1186/1476-4598-2-41

Punatar sb, noronha v, joshi a, prabhash k. Thyroid cancer in gardner's syndrome: case report and review of literature. South asian j cancer [serial online] 2012 [cited 2016 jun 10];1:43-7. Available from: http://journal.sajc.org/text.asp?2012/1/1/43/96510

http://jmedicalcasereports.biomedcentral.com/articles/10.1186/1752-1947-5-556 primary adenocarcinoma in the ileostomy of a woman with familial adenomatous polyposis: a case report and literature review by ahmed hammad et al., journal of medical case reports20115:556 doi: 10.1186/1752-1947-5-556

http://hccpjournal.biomedcentral.com/articles/10.1186/1897-4287-1-1-19 familial adenomatous polyposis (fap) and other polyposis syndromes by rodney j. Scott hereditary cancer in clinical practice20031:19 doi: 10.1186/1897-4287-1-1-19

https://ojrd.biomedcentral.com/articles/10.1186/1750-1172-4-22 familial adenomatous polyposis by elizabeth half,dani bercovich and paul rozen orphanet journal of rare diseases20094:22 doi: 10.1186/1750-1172-4-22

http://www.nejm.org/doi/full/10.1056/nejmoa012015#t=article primary chemoprevention of familial adenomatous polyposis with sulindac by francis m. Giardiello, m.d et al., n engl j med 2002; 346:1054-1059april 4, 2002doi: 10.1056/nejmoa012015

http://www.cancernetwork.com/review-article/genetic-testing-and-counseling-familial-adenomatous-polyposis-0genetic testing and counseling in familial adenomatous polyposis review article | january 01, 1996 by gloria m. Petersen, phd and jill d. Brensinger, ms

http://www.scielo.br/scielo.php?script=sci_arttext&pid=s0004-28032010000400010 arq. Gastroenterol. Vol.47 no.4 são paulo oct./dec. 2010 http://dx.doi.org/10.1590/s0004-28032010000400010 original article artigo original:desmoid tumor in patients with familial adenomatous polyposis by raquel franco leal et al.,

http://www.annalsgastro.gr/index.php/annalsgastro/article/view/1154/889 surgical treatment in familial adenomatous polyposis by vera n. Tudyka, susan k. Clark

http://press.endocrine.org/doi/full/10.1210/jcem.86.1.7095 thyroid carcinoma usually occurs in patients with familial adenomatous polyposis in the absence of biallelic inactivation of the adenomatous polyposis coli gene by f. Cetta et al., doi: http://dx.doi.org/10.1210/jcem.86.1.7095

http://www.joplink.net/prev/200801/200801_07.pdf the pancreas in familial adenomatous polyposis by alaa elkharwily, klaus gottlieb. Jop. J pancreas (online) 2008; 9(1):9-18.

http://hmg.oxfordjournals.org/content/10/7/721.full the abc of apc by nicola s. Fearnhead et al., oxford journals,medicine & health & science & mathematics,human molecular genetics,volume 10, issue 7 pp. 721-733

http://journals.lww.com/jpgn/fulltext/2010/12000/familial_adenomatous_polyposis_in_children_and.8.aspx?trendmd-shared=0 familial adenomatous polyposis in children and adolescents by alkhouri et al., journal of pediatric gastroenterology & nutrition:december 2010 - volume 51 - issue 6 - p 727–732 doi: 10.1097/mpg.0b013e3181e1a224

 

Related videos:

https://www.youtube.com/watch?v=qk5t7f_3iws familial adenomatous polyposis

https://www.youtube.com/watch?v=kwx6at-fh24 familial adenomatous polyposis (fap)

https://www.youtube.com/watch?v=1hup94h6ysw what you need to know about famalial adenomatous polyposis, by usmleteam

https://www.youtube.com/watch?v=bqdivkcy_4g attenuated familial adenomatous polyposis (fap)

https://www.youtube.com/watch?v=8mbvfbrwgzy familial adenomatous polyposis (fap)

https://www.youtube.com/watch?v=wn13aleg45u mcb164 assignment - familial adenomatous polyposis and colon cancer

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