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Factor v leiden mutation

Factor v leiden mutation

Last Reviewed : 12/25/2020
Factor v leiden mutation

Factor V Leiden thrombophilia is a genetic disorder of blood clotting. Factor V Leiden is a variant (mutated form) of human factor V (one of several substances that helps blood clot) that causes an increase in blood clotting (hypercoagulability). With this mutation, the protein secreted that helps blood not clot is unable to do so, and therefore clotting is more likely. Factor V Leiden is the most common hereditary hypercoagulability (prone to clotting) disorder amongst ethnic Europeans. It is named after the Dutch city Leiden, where it was first identified in 1994 by Prof R. Bertina et al.

 

We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.

 

Basic information:

http://www.mayoclinic.org/diseases-conditions/factor-v-leiden/basics/definition/con-20032637 mayo clinic factor v leiden

https://www.genome.gov/15015167/learning-about-factor-v-leiden-thrombophilia/ national human genome research institute factor v leiden thrombophilia

http://www.melbournehaematology.com.au/fact-sheets/factor-v-five-leiden-mutation.html melbourne hematology factor v (five) leiden mutation

http://www.healthline.com/health/factor-v-deficiency health line factor v deficiency

http://www.netdoctor.co.uk/conditions/heart-and-blood/a1150/factor-v-leiden/ net doctor uk factor v leiden

http://www.medicinenet.com/script/main/art.asp?articlekey=25022 medicine net.com definition of factor v leiden

http://www.pennstatehershey.org/c/document_library/get_file?uuid=12390055-e657-4a30-bf38-03a14a1bca9e&groupid=2751428 penn state hershey factor v leiden

 

Advanced information:

http://emedicine.medscape.com/article/209492-overview medscape factor v deficiency

https://www.stoptheclot.org/documents/factorvleiden-lw.pdf mc master childrens hospital factor v leiden

http://patient.info/in/doctor/factor-v-leiden-mutation-causing-thrombophilia patient factor v leiden mutation causing thrombophilia

http://www.dovemed.com/diseases-conditions/factor-v-leiden-thrombophilia/ dove med factor v leiden thrombophilia

 

Research:

http://circ.ahajournals.org/content/107/15/e94.full factor v leiden by deborah l. Ornstein, md; mary cushman, md, msc circulation.2003; 107: e94-e97doi: 10.1161/01.cir.0000068167.08920.f1

http://www.nature.com/gim/journal/v13/n1/full/gim920112a.html factor v leiden thrombophilia by jody lynn kujovich genetics in medicine (2011) 13, 1–16; doi:10.1097/gim.0b013e3181faa0f2

http://www.aefa.es/wp-content/uploads/2014/04/factor-v-leiden-and-other-coagulation-factor-mutations-affecting-thrombotic-risk.pdf factor v leiden and other coagulation factor mutations affecting thrombotic risk by rogier m. Bertina. Clinical chemistry 43:9 1678–1683 (1997)

http://www.scielo.br/scielo.php?script=sci_arttext&pid=s1415-47571999000200001 genet. Mol. Biol. Vol.22 n.2 são paulo june 1999 http://dx.doi.org/10.1590/s1415-47571999000200001 heterogeneous ethnic distribution of the factor v leiden mutation by rendrik f. Francoet al.,

http://www.sciencedirect.com/science/article/pii/s0741521497703483 the factor v leiden mutation: spectrum of thrombotic events and laboratory evaluation by franklin a. Bontempo, md et al., doi:10.1016/s0741-5214(97)70348-3journal of vascular surgery volume 25, issue 2, february 1997, pages 271–276

http://www.bloodjournal.org/content/96/13/4222?sso-checked=true spontaneous thrombosis in mice carrying the factor v leiden mutation by jisong cui et al., december 15, 2000; blood: 96 (13)

http://onlinelibrary.wiley.com/doi/10.1002/lt.500050211/pdf budd-chiari syndrome associated with factor v leiden mutation: a report of 6 patients by ron hoffman liver transplantation and surgery, vol 5, no 2 (march), 1999: pp 96-100

http://annals.org/article.aspx?articleid=710961 factor v leiden mutation and the risks for thromboembolic disease: a clinical perspective by daniel t. Price, md; and paul m. Ridker, md ann intern med. 1997;127(10):895-903. Doi:10.7326/0003-4819-127-10-199711150-00007

http://www.nejm.org/doi/full/10.1056/nejmc1405664#t=article activated protein c resistance assay and factor v leiden n engl j med 2014; 371:685-686august 14, 2014doi: 10.1056/nejmc1405664

http://www.clinchem.org/content/43/9/1703.full cross-linking hybridization assay for direct detection of factor v leiden mutation by james zehnder et al., clinical chemistryseptember 1997 vol. 43 no. 9 1703-1708

http://medind.nic.in/ica/t06/i5/icat06i5p236.pdf factor v leiden and prothrombin gene g20210a mutations are uncommon in portal vein thrombosis in india by sanjay sharma et al., indian journal of gastroenterology 2006 vol 25 september – october

http://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/1471-2474-2-1 the relationship of the factor v leiden mutation or the deletion-deletion polymorphism of the angiotensin converting enzyme to postoperative thromboembolic events following total joint arthroplasty by craig j della valle et al., bmc musculoskeletal disordersbmc series ¿ open, inclusive and trusted20012:1 doi: 10.1186/1471-2474-2-1

http://www.liverpoolctanaesthesia.com/resources/factor%20v%20leiden%20and%20perioperative%20risk.pdf factor v leiden and perioperative risk by brian s. Donahue, md, phd (anesth analg 2004;98:1623–34)

http://www.hindawi.com/journals/thrombosis/2012/594986/ thrombosis
volume 2012 (2012), article id 594986, 10 pages http://dx.doi.org/10.1155/2012/594986 review article:factor v leiden and inflammation by silvia perez-pujol et al.,

http://www.omicsonline.org/open-access/frequency-of-factor-ii-ga-and-factor-v-leiden-mutations-in-algerian-patients-with-venous-thromboembolism-2155-9864.1000247.php?aid=39107 chalal n, demmouche a, cherif touil s (2015) frequency of factor ii g20210a and factor v leiden mutations in algerian patients with venous thromboembolism. J blood disord transfus 6:247. Doi:10.4172/2155-9864.1000247

http://edoc.hu-berlin.de/oa/degruyter/cclm.1997.35.1.41.pdf discrimination between normal wildtype and carriers of coagulation factor v leiden mutation by the activated protein c resistance test in the presence of factor v deficient plasma by karl h. Reuner, frank litfin and heinrich patscheke eur j clin chem clin biochem 1997; 35(l):41-45

 

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