Factor V Leiden thrombophilia is a genetic disorder of blood clotting. Factor V Leiden is a variant (mutated form) of human factor V (one of several substances that helps blood clot) that causes an increase in blood clotting (hypercoagulability). With this mutation, the protein secreted that helps blood not clot is unable to do so, and therefore clotting is more likely. Factor V Leiden is the most common hereditary hypercoagulability (prone to clotting) disorder amongst ethnic Europeans. It is named after the Dutch city Leiden, where it was first identified in 1994 by Prof R. Bertina et al.
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http://annals.org/article.aspx?articleid=710961 factor v leiden mutation and the risks for thromboembolic disease: a clinical perspective by daniel t. Price, md; and paul m. Ridker, md ann intern med. 1997;127(10):895-903. Doi:10.7326/0003-4819-127-10-199711150-00007
http://medind.nic.in/ica/t06/i5/icat06i5p236.pdf factor v leiden and prothrombin gene g20210a mutations are uncommon in portal vein thrombosis in india by sanjay sharma et al., indian journal of gastroenterology 2006 vol 25 september – october
http://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/1471-2474-2-1 the relationship of the factor v leiden mutation or the deletion-deletion polymorphism of the angiotensin converting enzyme to postoperative thromboembolic events following total joint arthroplasty by craig j della valle et al., bmc musculoskeletal disordersbmc series ¿ open, inclusive and trusted20012:1 doi: 10.1186/1471-2474-2-1
http://edoc.hu-berlin.de/oa/degruyter/cclm.19188.8.131.52.pdf discrimination between normal wildtype and carriers of coagulation factor v leiden mutation by the activated protein c resistance test in the presence of factor v deficient plasma by karl h. Reuner, frank litfin and heinrich patscheke eur j clin chem clin biochem 1997; 35(l):41-45