Diabetes insipidus

Diabetes insipidus

Last Reviewed : 12/25/2020
Diabetes insipidus

Diabetes insipidus (DI) is a condition characterized by excessive thirst and excretion of large amounts of severely dilute urine, with reduction of fluid intake having no effect on the concentration of the urine. There are different types of DI, each with a different set of causes. The most common type in humans is the neurological form, called central DI (CDI), which involves a deficiency of arginine vasopressin (AVP), also known as antidiuretic hormone (ADH). The second common type of DI is nephrogenic diabetes insipidus (NDI), which is due to kidney or nephron dysfunction caused by an insensitivity of the kidneys or nephrons to ADH. DI can also be gestational, or caused by alcohol or some types of drug abuse. DI should not be confused with nocturia.

Although they have a common name, diabetes mellitus and diabetes insipidus are two entirely separate conditions with unrelated mechanisms. Both cause large amounts of urine to be produced (polyuria). However, diabetes insipidus is either a problem with the production of antidiuretic hormone (central diabetes insipidus) or kidney's response to antidiuretic hormone (nephrogenic diabetes insipidus), whereas diabetes mellitus causes polyuria via a process called osmotic diuresis, due to the high blood sugar leaking into the urine and taking excess water along with it.

The number of new cases of diabetes insipidus each year is 3 in 100,000. Diabetes insipidus usually starts in childhood or early adulthood and affects men more commonly than women. The term "diabetes" is derived from the Greek word meaning siphon.


We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.


Basic information:

https://medlineplus.gov/ency/article/000377.htm medline plus diabetes insipidus

https://www.niddk.nih.gov/health-information/health-topics/kidney-disease/diabetes-insipidus/pages/facts.aspxnational institute of diabetes and kidney and digestive disorders diabetes insipidus

http://www.mayoclinic.org/diseases-conditions/diabetes-insipidus/home/ovc-20182403 mayo clinic diabetes insipidus

http://www.webmd.com/diabetes/guide/what-is-diabetes-insipidus web md what is diabetes insipidus?

http://www.nhs.uk/conditions/diabetes-insipidus/pages/introduction.aspx nhs uk diabetes insipidus

http://www.merckmanuals.com/home/hormonal-and-metabolic-disorders/pituitary-gland-disorders/central-diabetes-insipidus merck manuals central diabetes insipidus

http://www.healthline.com/health/type-2-diabetes/diabetes-insipidus health line diabetes insipidus

https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/diabetes-insipidus better health diabetes insipidus

http://familydoctor.org/familydoctor/en/diseases-conditions/diabetes-insipidus.html family doctor diabetes insipidus

http://www.nytimes.com/health/guides/disease/diabetes-insipidus/overview.html new york times diabetes insipidus

http://www.msdmanuals.com/home/kidney-and-urinary-tract-disorders/disorders-of-kidney-tubules/nephrogenic-diabetes-insipidus msd manuals nephrogenic diabetes insipidus

http://umm.edu/health/medical/ency/articles/diabetes-insipidus university of maryland medical center diabetes insipidus

https://www.healthgrades.com/conditions/diabetes-insipidus health grades diabetes insipidus

http://www.aboutkidshealth.ca/en/resourcecentres/braintumours/lookingahead/growthdevelopmentandhormonaleffects/pages/diabetes-insipidus.aspx about kids health diabetes insipidus after brain tumour treatment


Advanced information:

http://emedicine.medscape.com/article/117648-overview medscape diabetes insipidus

http://www.medicalnewstoday.com/articles/183251.php medical news today diabetes insipidus: causes, symptoms and treatment

http://patient.info/in/doctor/diabetes-insipidus-pro patient diabetes insipidus

http://lifeinthefastlane.com/ccc/central-diabetes-insipidus/ life in the fast lane central diabetes insipidus

http://www.fpnotebook.com/renal/endo/dbtsinspds.htm family practise notebook diabetes insipidus

http://rarediseases.org/rare-diseases/central-diabetes-insipidus/ national organisation for rare diseases central diabetes insipidus

http://radiopaedia.org/articles/diabetes-insipidus radiopedia diabetes insipidus

http://www.hse.ie/eng/health/az/d/diabetes-insipidus/treating-diabetes-insipidus.html health service executive diabetes insipidus

http://www.medbullets.com/step1-endocrine/9028/diabetes-insipidus med bullets diabetes insipidus

http://www.healthcommunities.com/understanding-diabetes/what-is-diabetes-insipidus.shtml health communities diabetes insipidus

http://www.rightdiagnosis.com/a/autoimmune_diabetes_insipidus/intro.htm right diagnosis autoimmune diabetes insipidus

http://www.dovemed.com/diseases-conditions/nephrogenic-diabetes-insipidus/ dove med nephrogenic diabetes insipidus



http://ojrd.biomedcentral.com/articles/10.1186/1750-1172-7-92 early presentation of gait impairment in wolfram syndrome by kristen a pickett et al., orphanet journal of rare diseases20127:92 doi: 10.1186/1750-1172-7-92

http://bmcneurosci.biomedcentral.com/articles/10.1186/1471-2202-9-54 apoptosis of supraoptic avp neurons is involved in the development of central diabetes insipidus after hypophysectomy in rats by yihua wang et al., bmc neuroscience20089:54 doi: 10.1186/1471-2202-9-54

http://thyroidresearchjournal.biomedcentral.com/articles/10.1186/1756-6614-1-7 new onset graves' disease as a cause of an adrenal crisis in an individual with panhypopituitarism: brief report by krzysztof c lewandowski et al.,hyroid research20081:7 doi: 10.1186/1756-6614-1-7

http://www.scielo.br/scielo.php?script=sci_arttext&pid=s0004-282x2000000500020 arq. Neuro-psiquiatr. Vol.58 n.3b são paulo sept. 2000 http://dx.doi.org/10.1590/s0004-282x2000000500020 generalized status epilepticus associated with massive pulmonary aspiration and transient central diabetes insipidus case report by mauricio carvalho et al.,

https://www.hindawi.com/journals/crie/2016/2047410/ resmi premji, nira roopnarinesingh, joshua cohen, and sabyasachi sen, “cerebral malaria: an unusual cause of central diabetes insipidus,” case reports in endocrinology, vol. 2016, article id 2047410, 4 pages, 2016. Doi:10.1155/2016/2047410

https://www.hindawi.com/journals/crj/2016/3740902/ k. Earlam, c. A. Souza, r. Glikstein, m. M. Gomes, and s. Pakhalé, “pulmonary langerhans cell histiocytosis and diabetes insipidus in a young smoker,” canadian respiratory journal, vol. 2016, article id 3740902, 5 pages, 2016. Doi:10.1155/2016/3740902

https://www.hindawi.com/journals/crie/2014/693294/ masahiro asakawa, rina chin, yoshihiro niitsu, et al., “a case of rathke’s cleft cyst associated with transient central adrenal insufficiency and masked diabetes insipidus,” case reports in endocrinology, vol. 2014, article id 693294, 6 pages, 2014. Doi:10.1155/2014/693294

http://europepmc.org/backend/ptpmcrender.fcgi?accid=pmc4161373&blobtype=pdf matsunaga k, tanabe k, inoue h, okuya s, ohta y, et al. (2014) wolfram syndrome in the japanese population; molecular analysis of wfs1 gene and characterization of clinical features. Plos one 9(9): e106906. Doi:10.1371/journal.pone.0106906

Kumar m, dutta d, shivaprasad k s, jain r, sen a, biswas d, mukhopadhyay m, ghosh s, mukhopadhyay s, chowdhury s. Diabetes insipidus as a presenting manifestation of rathke's cleft cyst. Indian j endocr metab [serial online] 2013 [cited 2016 aug 31];17, suppl s1:127-9. Available from: http://www.ijem.in/text.asp?2013/17/7/127/119529

http://www.scielo.br/scielo.php?script=sci_arttext&pid=s0004-282x2008000300028 arq. Neuro-psiquiatr. Vol.66 no.2b são paulo june 2008 http://dx.doi.org/10.1590/s0004-282x2008000300028 clinical/scientific notes transient central diabetes insipidus followed by pituitary apoplexy treated in a conservative way by cintia marques dos santos silva et al.,

http://bmcpediatr.biomedcentral.com/articles/10.1186/1471-2431-12-56 rare neonatal diabetes insipidus and associated late risks: case report by maximiliano francisco rivas-crespo et al., bmc pediatrics201212:56 doi: 10.1186/1471-2431-12-56

http://www.scielo.br/scielo.php?script=sci_arttext&pid=s0004-27302008000800011 arq bras endocrinol metab vol.52 no.8 são paulo nov. 2008 http://dx.doi.org/10.1590/s0004-27302008000800011 clinical case report autosomal dominant familial neurohypophyseal diabetes insipidus caused by a novel mutation in arginine-vasopressin gene in a brazilian family by maria edna de melo et al.,

https://www.hindawi.com/journals/isrn/2013/797620/ chadi saifan, rabih nasr, suchita mehta, et al., “diabetes insipidus: a challenging diagnosis with new drug therapies,” isrn nephrology, vol. 2013, article id 797620, 7 pages, 2013. Doi:10.5402/2013/797620


Other articles:

http://www.petmd.com/dog/conditions/endocrine/c_dg_diabetes_insipidus pet md water diabetes in dogs

http://www.merckvetmanual.com/mvm/endocrine_system/the_pituitary_gland/diabetes_insipidus.html the merck veterinary manual diabetes insipidus

http://www.vcahospitals.com/main/pet-health-information/article/animal-health/diabetes-insipidus-in-dogs/743 vca animal hospitals diabetes insipidus in dogs

http://www.caninediabetes.org/pdorg/diabetes_insipidus.htm canine diabetes diabetes insipidus

http://www.pethealthnetwork.com/dog-health/dog-diseases-conditions-a-z/diabetes-insipidus-water-diabetes-cats-and-dogs pet health network diabetes insipidus (water diabetes) in cats and dogs

http://www.vetstreet.com/care/diabetes-insipidus-in-cats vet street diabetes insipidus in cats

http://www.surroundedbycats.com/di-whatisit.html what is diabetes insipidus (di)?


Other helpful resources(support groups):

https://www.histio.org/page.aspx?pid=407#.v8kefdkufp0 histocytosis association diabetes insipidus

http://www.pituitary.org.uk/information/pituitary-conditions/diabetes-insipidus/ the pitutary foundation

http://www.ndif.org/ ndi foundation


Related videos:

https://www.youtube.com/watch?v=hpt1pcevfmw diabetes insipidus

https://www.youtube.com/watch?v=efhzd1vqjac central diabetes insipidus

https://www.youtube.com/watch?v=sk8ite3-v20 nephrogenic diabetes insipidus

https://www.youtube.com/watch?v=lo7dpakwvfe diabetes insipidus - usmle step 2 review

https://www.youtube.com/watch?v=ic5npfnvark diabetes insipidus nclex® review | nrsngacademy.com

https://www.youtube.com/watch?v=pthrkktjxl0 siadh vs. Di


Presentations/quiz/newspaper articles:

http://www.slideshare.net/drunnikrishnanz/diabetes-insipidus-13553900 diabetes insipidus

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