cushings-disease
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Cushings disease

Cushings disease

Last Reviewed : 12/25/2020
Cushings disease

Cushing's disease is a cause of Cushing's syndrome characterised by increased secretion of adrenocorticotropic hormone (ACTH) from the anterior pituitary (secondary hypercortisolism). This is most often as a result of a pituitary adenoma (specifically pituitary basophilism) or due to excess production of hypothalamus CRH (Corticotropin releasing hormone) (tertiary hypercortisolism/hypercorticism) that stimulates the synthesis of cortisol by the adrenal glands. Pituitary adenomas are responsible for 80% of endogenous Cushing's syndrome, when excluding Cushing's syndrome from exogenously administered corticosteroids.

This should not be confused with ectopic Cushing syndrome or exogenous steroid use.

 

We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.

 

Basic information:

https://medlineplus.gov/ency/article/000348.htm medline plus cushing's syndrome

http://www.mayoclinic.org/diseases-conditions/cushing-syndrome/symptoms-causes/dxc-20197177 mayoclinic symptoms and causes

http://www.healthline.com/health/cushing-syndrome healthline cushing's syndrome

http://www.nhs.uk/conditions/cushings-syndrome/pages/introduction.aspx nhs uk cushing's syndrome

http://www.webmd.com/a-to-z-guides/cushing-syndrome#1 web md cushing's syndrome

https://www.niddk.nih.gov/health-information/health-topics/endocrine/cushings-syndrome/pages/fact-sheet.aspx national institute for diabetes and digestive and kidney disorders cushing's syndrome

https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/cushings-syndrome better health cushing's syndrome

https://www.msdmanuals.com/professional/endocrine-and-metabolic-disorders/adrenal-disorders/cushing-syndrome msd manuals (professional version) cushing syndrome

http://www.nytimes.com/health/guides/disease/cushings-disease/overview.html newyork times cushing disease

http://my.clevelandclinic.org/health/diseases_conditions/hic_cushings_syndrome cleveland clinic cushing's syndrome

https://labtestsonline.org/understanding/conditions/cushing/ la tests online cushing syndrome

 

Advanced information:

http://www.medicinenet.com/cushings_syndrome/article.htm medicine net cushing's syndrome

http://patient.info/in/health/cushings-syndrome-leaflet patient cushing's syndrome

http://emedicine.medscape.com/article/117365-overview medscape iatrogenic cushing syndrome

http://www.fpnotebook.com/endo/adrenal/cshngsds.htm family practise notebook cushing's syndrome

http://www.aafp.org/afp/2000/0901/p1119.html american family physician cushing's disease: clinical manifestations and diagnostic evaluation

 

Research:

Prajapati o p, verma a k, mishra a, agarwal g, agarwal a, mishra s k. Bilateral adrenalectomy for cushing's syndrome: pros and cons. Indian j endocr metab [serial online] 2015 [cited 2016 sep 25];19:834-40. Available from: http://www.ijem.in/text.asp?2015/19/6/834/167544

http://europepmc.org/backend/ptpmcrender.fcgi?accid=pmc4370384&blobtype=pdf : aulinas a, ramírez m-j, barahona m-j, valassi e, resmini e, mato e, et al. (2015) dyslipidemia and chronic inflammation markers are correlated with telomere length shortening in cushing’s syndrome. Plos one 10(3): e0120185. Doi:10.1371/journal.pone.0120185

https://www.hindawi.com/journals/crie/2013/205208/ aldo schenone giugni, shylaja mani, subramanian kannan, and betul hatipoglu, “exophthalmos: a forgotten clinical sign of cushing's syndrome,” case reports in endocrinology, vol. 2013, article id 205208, 3 pages, 2013. Doi:10.1155/2013/205208

https://www.hindawi.com/journals/jo/2012/685213/ carlotta pozza, chiara graziadio, elisa giannetta, andrea lenzi, and andrea m. Isidori, “management strategies for aggressive cushing's syndrome: from macroadenomas to ectopics,” journal of oncology, vol. 2012, article id 685213, 9 pages, 2012. Doi:10.1155/2012/685213

http://europepmc.org/backend/ptpmcrender.fcgi?accid=pmc2883593&blobtype=pdf sahut-barnola i, de joussineau c, val p, lambert-langlais s, damon c, et al. (2010) cushing’s syndrome and fetal features resurgence in adrenal cortex–specific prkar1a knockout mice. Plos genet 6(6): e1000980. Doi:10.1371/journal.pgen.1000980

http://europepmc.org/backend/ptpmcrender.fcgi?accid=pmc2854133&blobtype=pdf bangaru mly, woodliff j, raff h, kansra s (2010) growth suppression of mouse pituitary corticotroph tumor att20 cells by curcumin: a model for treating cushing’s disease. Plos one 5(4): e9893. Doi:10.1371/journal.pone.0009893

http://www.sciencedirect.com/science/article/pii/s2213158214000187 widespread reductions of white matter integrity in patients with long-term remission of cushing's disease by steven j.a. Van der werffet al., neuroimage: clinical volume 4, 2014, pages 659–667 http://dx.doi.org/10.1016/j.nicl.2014.01.017

http://www.sciencedirect.com/science/article/pii/s2352187215000054 insights on accelerated skeletal repair in cushing's disease by so-young kim et al., bone reports volume 2, june 2015, pages 32–35 http://dx.doi.org/10.1016/j.bonr.2015.03.001

 

Other articles:

http://www.petmd.com/dog/conditions/endocrine/c_dg_hyperadrenocorticism pet md hyperadrenocorticism in dogs

http://pets.webmd.com/dogs/cushings-syndrome-dogs pet education cushing’s syndrome in dogs

http://www.peteducation.com/article.cfm?c=2+2114&aid=416 cushing's disease (hyperadrenocorticism) in dogs

http://www.canismajor.com/dog/cushings.html dog owners guide cushing's syndrome

http://www.vcahospitals.com/main/pet-health-information/article/animal-health/cushings-disease-in-dogs/545 vca animal hospitals cushing’s disease in dogs

http://www.merckvetmanual.com/mvm/endocrine_system/the_adrenal_glands/hyperadrenocorticism.html merck veterinary manual hyperadrenocorticism

http://icatcare.org/advice/cat-health/hyperadrenocorticism-cushings-disease international cat care hyperadrenocorticism (cushing's disease)

http://www.petdoctors.co.uk/pet-advice/dogs/medical-conditions-and-surgery/cushings-disease/ pet doctors cushing's syndrome

http://dogtime.com/dog-health/general/788-dogs-with-cushings-disease-aaha dog time cushing’s disease: a quality of life issue
read more at http://dogtime.com/dog-health/general/788-dogs-with-cushings-disease-aaha#qvutp9ctuhvx7eul.99

http://www.vetstreet.com/care/hyperadrenocorticism-cushings-disease-in-dogs vet street hyperadrenocorticism (cushing's disease) in dogs

 

Other helpful resources(support groups):

http://www.nadf.us/adrenal-diseases/cushings-syndrome/ national adrenal disease foundation

 

Related videos:

https://www.youtube.com/watch?v=1osiatrto2k cushing's syndrome - made easy

https://www.youtube.com/watch?v=sig78qotucs cushing syndrome

https://www.youtube.com/watch?v=2-5xabjakpe cushing syndrome

https://www.youtube.com/watch?v=xnhvcar8f_o cushings syndrome and the dexamethasone suppression test

https://www.youtube.com/watch?v=niqkatzsjte cushings syndrome

https://www.youtube.com/watch?v=c8yn4njbl7w 3-cushing syndrome

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