Cushings disease

Cushings disease

Last Reviewed : 12/25/2020
Cushings disease

Cushing's disease is a cause of Cushing's syndrome characterised by increased secretion of adrenocorticotropic hormone (ACTH) from the anterior pituitary (secondary hypercortisolism). This is most often as a result of a pituitary adenoma (specifically pituitary basophilism) or due to excess production of hypothalamus CRH (Corticotropin releasing hormone) (tertiary hypercortisolism/hypercorticism) that stimulates the synthesis of cortisol by the adrenal glands. Pituitary adenomas are responsible for 80% of endogenous Cushing's syndrome, when excluding Cushing's syndrome from exogenously administered corticosteroids.

This should not be confused with ectopic Cushing syndrome or exogenous steroid use.


We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.


Basic information: medline plus cushing's syndrome mayoclinic symptoms and causes healthline cushing's syndrome nhs uk cushing's syndrome web md cushing's syndrome national institute for diabetes and digestive and kidney disorders cushing's syndrome better health cushing's syndrome msd manuals (professional version) cushing syndrome newyork times cushing disease cleveland clinic cushing's syndrome la tests online cushing syndrome


Advanced information: medicine net cushing's syndrome patient cushing's syndrome medscape iatrogenic cushing syndrome family practise notebook cushing's syndrome american family physician cushing's disease: clinical manifestations and diagnostic evaluation



Prajapati o p, verma a k, mishra a, agarwal g, agarwal a, mishra s k. Bilateral adrenalectomy for cushing's syndrome: pros and cons. Indian j endocr metab [serial online] 2015 [cited 2016 sep 25];19:834-40. Available from: : aulinas a, ramírez m-j, barahona m-j, valassi e, resmini e, mato e, et al. (2015) dyslipidemia and chronic inflammation markers are correlated with telomere length shortening in cushing’s syndrome. Plos one 10(3): e0120185. Doi:10.1371/journal.pone.0120185 aldo schenone giugni, shylaja mani, subramanian kannan, and betul hatipoglu, “exophthalmos: a forgotten clinical sign of cushing's syndrome,” case reports in endocrinology, vol. 2013, article id 205208, 3 pages, 2013. Doi:10.1155/2013/205208 carlotta pozza, chiara graziadio, elisa giannetta, andrea lenzi, and andrea m. Isidori, “management strategies for aggressive cushing's syndrome: from macroadenomas to ectopics,” journal of oncology, vol. 2012, article id 685213, 9 pages, 2012. Doi:10.1155/2012/685213 sahut-barnola i, de joussineau c, val p, lambert-langlais s, damon c, et al. (2010) cushing’s syndrome and fetal features resurgence in adrenal cortex–specific prkar1a knockout mice. Plos genet 6(6): e1000980. Doi:10.1371/journal.pgen.1000980 bangaru mly, woodliff j, raff h, kansra s (2010) growth suppression of mouse pituitary corticotroph tumor att20 cells by curcumin: a model for treating cushing’s disease. Plos one 5(4): e9893. Doi:10.1371/journal.pone.0009893 widespread reductions of white matter integrity in patients with long-term remission of cushing's disease by steven j.a. Van der werffet al., neuroimage: clinical volume 4, 2014, pages 659–667 insights on accelerated skeletal repair in cushing's disease by so-young kim et al., bone reports volume 2, june 2015, pages 32–35


Other articles: pet md hyperadrenocorticism in dogs pet education cushing’s syndrome in dogs cushing's disease (hyperadrenocorticism) in dogs dog owners guide cushing's syndrome vca animal hospitals cushing’s disease in dogs merck veterinary manual hyperadrenocorticism international cat care hyperadrenocorticism (cushing's disease) pet doctors cushing's syndrome dog time cushing’s disease: a quality of life issue
read more at vet street hyperadrenocorticism (cushing's disease) in dogs


Other helpful resources(support groups): national adrenal disease foundation


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