Cushing's disease is a cause of Cushing's syndrome characterised by increased secretion of adrenocorticotropic hormone (ACTH) from the anterior pituitary (secondary hypercortisolism). This is most often as a result of a pituitary adenoma (specifically pituitary basophilism) or due to excess production of hypothalamus CRH (Corticotropin releasing hormone) (tertiary hypercortisolism/hypercorticism) that stimulates the synthesis of cortisol by the adrenal glands. Pituitary adenomas are responsible for 80% of endogenous Cushing's syndrome, when excluding Cushing's syndrome from exogenously administered corticosteroids.
This should not be confused with ectopic Cushing syndrome or exogenous steroid use.
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https://www.hindawi.com/journals/crie/2013/205208/ aldo schenone giugni, shylaja mani, subramanian kannan, and betul hatipoglu, “exophthalmos: a forgotten clinical sign of cushing's syndrome,” case reports in endocrinology, vol. 2013, article id 205208, 3 pages, 2013. Doi:10.1155/2013/205208
https://www.hindawi.com/journals/jo/2012/685213/ carlotta pozza, chiara graziadio, elisa giannetta, andrea lenzi, and andrea m. Isidori, “management strategies for aggressive cushing's syndrome: from macroadenomas to ectopics,” journal of oncology, vol. 2012, article id 685213, 9 pages, 2012. Doi:10.1155/2012/685213