crohns-disease
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Crohns disease

Crohns disease

Last Reviewed : 12/25/2020
Crohns disease

Crohn's disease is a type of inflammatory bowel disease (IBD) that may affect any part of the gastrointestinal tract from mouth to anus. Signs and symptoms often include abdominal pain, diarrhea (which may be bloody if inflammation is severe), fever, and weight loss. Other complications may occur outside the gastrointestinal tract and include anemia, skin rashes, arthritis, inflammation of the eye, and feeling tired. The skin rashes may be due to infections as well as pyoderma gangrenosum or erythema nodosum. Bowel obstruction also commonly occurs and those with the disease are at greater risk of bowel cancer.

Crohn's disease is caused by a combination of environmental, immune and bacterial factors in genetically susceptible individuals. It results in a chronic inflammatory disorder, in which the body's immune system attacks the gastrointestinal tract possibly directed at microbial antigens. While Crohn's is an immune related disease, it does not appear to be an autoimmune disease (in that the immune system is not being triggered by the body itself). The exact underlying immune problem is not clear; however, it may be an immunodeficiency state. About half of the overall risk is related to genetics with more than 70 genes found to be involved. Tobacco smokers are two times more likely to develop Crohn's disease than nonsmokers. It also often begins after gastroenteritis. Diagnosis is based on a number of findings including biopsy and appearance of the bowel wall, medical imaging and description of the disease. Other conditions that can present similarly include irritable bowel syndrome and Behçet's disease.

There are no medications or surgical procedures that can cure Crohn's disease. Treatment options can only help with symptoms, maintain remission, and prevent relapse. In those newly diagnosed, a corticosteroid may be used for a brief period of time to quickly improve the disease with another medication such as either methotrexate or a thiopurine used to prevent recurrence. An important part of treatment is the stopping of smoking among those who do. One in five people with the disease are admitted to hospital each year, and half of those with the disease will require surgery for the disease at some point over a ten-year period. While surgery should be used as little as possible, it is necessary to address some abscesses, certain bowel obstructions, and cancers. Checking for bowel cancer via colonoscopy is recommended every few years, starting eight years after the disease has begun.

Crohn's disease affects about 3.2 per 1,000 people in Europe and North America. It is less common in Asia and Africa. It has historically been more common in the developed world. Rates have, however, been increasing, particularly in the developing world, since the 1970s. Inflammatory bowel disease resulted in 35,000 deaths in 2010 and those with Crohn's disease have a slightly reduced life expectancy. It tends to start in the teens and twenties, although it can occur at any age. Males and females are equally affected. The disease was named after gastroenterologist Burrill Bernard Crohn, who, in 1932, together with two other colleagues at Mount Sinai Hospital in New York, described a series of patients with inflammation of the terminal ileum of the small intestine, the area most commonly affected by the illness.

 

We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.

 

Basic information:

http://www.mayoclinic.org/diseases-conditions/crohns-disease/basics/definition/con-20032061 crohn's disease

http://www.webmd.com/ibd-crohns-disease/crohns-disease/ crohn's disease

http://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/crohns-disease/pages/facts.aspx national institute for diabetes and digestive and kidney diseases crohn's disease

http://www.healthline.com/health/crohns-disease health line what do you want to know about crohn's disease?

http://www.nhs.uk/conditions/crohns-disease/pages/introduction.aspx nhs uk crohn's disease

https://www.crohnsandcolitis.com/crohns/what-is-crohns-disease what is crohn's disease

https://www.crohnsandcolitis.org.uk/about-inflammatory-bowel-disease/crohns-disease crohns & colitis uk crohn's disease

http://www.crohnsandcolitis.ca/site/c.dtjrl9nujml4h/b.9012447/k.9287/crohns_disease.htm crohns & colitis canada crohn's disease

http://www.everydayhealth.com/crohns-disease/guide/ every day health crohn's disease

http://www.bupa.co.uk/health-information/directory/c/crohns-disease bupa crohn's disease

http://www.netdoctor.co.uk/conditions/digestive-health/a4907/crohns-disease/ net doctor crohn's disease

https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/crohns-disease-and-ulcerative-colitis better health crohn's disease

http://www.healthnavigator.org.nz/health-a-z/c/crohns-disease/ health navigator crohn's disease

http://my.clevelandclinic.org/health/diseases_conditions/hic_inflammatory_bowel_disease_ibd_qanda/hic_crohns_disease crohn's disease

http://www.bupa.com.au/health-and-wellness/health-information/az-health-information/crohn's-disease bupa crohn's disease

http://www.nytimes.com/health/guides/disease/crohns-disease/overview.html new york times crohn's disease

http://www.emedicinehealth.com/crohn_disease_faqs/article_em.htm emedicine health crohn's disease

https://www.fascrs.org/patients/disease-condition/crohns-disease-0 american society of colon and rectal surgeons crohn's disease

http://www.healthdirect.gov.au/crohns-disease-and-ulcerative-colitis health direct crohn's disease

https://www.hse.ie/eng/health/az/c/crohn's-disease/ health service executive crohn's disease

http://bodyandhealth.canada.com/condition/getcondition/crohns-disease body ans health.ca crohn's disease

http://www.aboutkidshealth.ca/en/healthaz/conditionsanddiseases/inflammatoryconditions/pages/crohns-disease.aspxabout kids health crohn's disease

 

Advanced information:

http://www.medicinenet.com/crohns_disease/article.htm medicine net crohn's disease

http://www.cdd.com.au/pages/disease_info/crohns_disease.html centre for digestive diseases crohn's disease

http://emedicine.medscape.com/article/172940-overview medscape crohn's disease

http://radiopaedia.org/articles/crohn-disease-1 radiopedia crohn's disease

http://patient.info/health/crohns-disease-leaflet patient crohn's disease

http://www.crohns.org.uk/crohns_disease/what-is-crohnss-disease-cd crohns.org crohn's disease

https://www.southerncross.co.nz/aboutthegroup/healthresources/medicallibrary/tabid/178/vw/1/itemid/523/crohns-disease-symptoms-diagnosis-treatment.aspx southern cross medical library crohn's disease - symptoms, diagnosis, treatment

http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/gastroenterology/crohns-disease/ crohn's disease

http://www.dermnetnz.org/systemic/crohns-skin.html dermnet nz crohn's disease

http://s3-eu-west-1.amazonaws.com/files.crohnsandcolitis.org.uk/publications/crohns-disease.pdf crohns and colitis uk crohn's disease

http://www.radiologyassistant.nl/en/p5289d9a1932db/crohns-disease.html radiology assistant crohn's disease

http://www.radiologyinfo.org/en/info.cfm?pg=crohns-disease riology info crohn's disease ad

http://www.britannica.com/science/crohn-disease britannica crohn's disease

https://www.genome.gov/25521854/learning-about-crohns-disease/ national human genome research institute crohn's disease

http://www.cdc.gov/ibd/ibd-epidemiology.htm cdc epidemiology of the ibd

 

Research:

http://www.hindawi.com/journals/cris/2013/421961/ case reports in surgery
volume 2013 (2013), article id 421961, 3 pages http://dx.doi.org/10.1155/2013/421961case report:isolated duodenal crohn's disease: a case report and a review of the surgical management by faruk karateke et al.,

http://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230x-1-8 is it crohn's disease? A severe systemic granulomatous reaction to sulfasalazine in patient with rheumatoid arthritis by leonard g quallich et al., bmc gastroenterologybmc series ¿ open, inclusive and trusted20011:8 doi: 10.1186/1471-230x-1-8

http://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230x-11-57 spontaneous remission of crohn's disease following a febrile infection: case report and literature review by stephen a hoption cann and johannes p van netten bmc gastroenterologybmc series ¿ open, inclusive and trusted201111:57 doi: 10.1186/1471-230x-11-57

http://mrmjournal.biomedcentral.com/articles/10.1186/2049-6958-5-5-312 methotrexate-induced pneumonitis in crohn's disease. Case report and review of the literature by nadia d'andrea et al., multidisciplinary respiratory medicine20105:312 doi: 10.1186/2049-6958-5-5-312

http://www.scielo.br/scielo.php?script=sci_arttext&pid=s0004-28032000000400007 arq. Gastroenterol. Vol.37 no.4 são paulo oct./nov. 2000 http://dx.doi.org/10.1590/s0004-28032000000400007 relato de casos / case reports:fatal evolution of systemic lupus erythematosus associated with crohn's disease by júlio m. Fonseca chebli et al.,

http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=s1130-01082014000600002&lng=en&tlng=en rev. Esp. Enferm. Dig. Vol.106 n.6 jun. 2014 original papers:treatment preferences of patients with crohn's disease: development of the implica questionnaire by natalia borruel et al.,

http://www.scielo.br/scielo.php?script=sci_arttext&pid=s0004-28032014000200090&lng=en&tlng=en arq. Gastroenterol. Vol.51 no.2 são paulo apr./june 2014 http://dx.doi.org/10.1590/s0004-28032014000200004 original articles:gender-related differences in clinical course of crohn’s disease in an asian population: a retrospective cohort review by siu-tong law, kin kong li

http://www.ojhas.org/issue24/2007-4-6.htm bhat ms, ashfaque m, balu k, madhusudhanan j, sendhil rk. A rare presentation of crohn's disease. Online j health allied scs. 2007;4:6

http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=s1130-01082014000700005&lng=en&tlng=en rev. Esp. Enferm. Dig. Vol.106 n.7 jul./aug. 2014 reviews:mucosal healing in crohn's disease: relevance and controversies in real life clinical practice by yago gonzález-lama et al.,

http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=s1130-01082010000500009 rev. Esp. Enferm. Dig. Vol.102 no.5 may. 2010 clinical note:crohn's disease and sweet's syndrome: an uncommon association by catalán-serra et al.,

http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=s1130-01082015001000002&lng=en&tlng=en rev. Esp. Enferm. Dig. Vol.107 n.10 oct. 2015 original papers:impact of endoscopic monitoring in postoperative crohn's disease patients already receiving pharmacological prevention of recurrence by yago gonzález-lama et al.,

http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=s1130-01082014000100006&lng=en&tlng=en rev. Esp. Enferm. Dig. Vol.106 n.1 jan. 2014 http://dx.doi.org/10.4321/s1130-01082014000100006 review:indications of capsule endoscopy in crohn's disease by marisol luján-sanchis et al

 

Other helpful resources(support groups):

http://www.ccfa.org/what-are-crohns-and-colitis/what-is-crohns-disease/?referrer=https://www.google.co.in/ crohns and colitis foundation of america

https://www.crohnsandcolitis.com.au/about-crohns-colitis/ crohns and colitis foundation of australia

https://celiac.org/celiac-disease/celiac-disease-and-crohns-disease/ celiac disease organisation

 

Other articles:

https://www.organicfacts.net/home-remedies/crohns-disease.html organic facts home remedies for crohn’s disease

 

Related videos:

https://www.youtube.com/watch?v=k0krsf80pj0 what is crohn's disease?

https://www.youtube.com/watch?v=dcdhznjrnla what is crohn's disease?

https://www.youtube.com/watch?v=ivckaxxagm4 crohn disease

https://www.youtube.com/watch?v=l94f-6b8iz4 colonoscopy of crohn's disease

https://www.youtube.com/watch?v=thzojv-chro crohn's disease (crohn disease) - symptoms & pathophysiology

https://www.youtube.com/watch?v=53u4nvfn3e4 crohn's disease: symptoms, diagnosis, treatment - gateway gastroenterology

https://www.youtube.com/watch?v=zuhpxaj8imq ibd school 102 - what is crohn's disease?

 

Presentations/quiz/newspaper articles:

http://www.dailymail.co.uk/health/article-3565467/mother-three-died-agony-crohn-s-disease-doctors-said-imagining-pain.html daily mail mother-of-three died in agony from crohn's disease after doctors said she was 'imagining most of her pain'

read more: http://www.dailymail.co.uk/health/article-3565467/mother-three-died-agony-crohn-s-disease-doctors-said-imagining-pain.html#ixzz4ajsrwuvs

http://www.newsmax.com/fastfeatures/digestive-system-diseases-crohns-disease/2016/04/20/id/725015/ newsmax digestive system diseases: 15 signs of crohn's disease

http://www.medicaldaily.com/medical-marijuana-achieves-complete-remission-crohns-disease-drug-improves-appetite-and-sleep-247783 medical daily medical marijuana achieves ‘complete remission’ of crohn's disease; drug improves appetite and sleep function, with no side effects

http://www.cbsnews.com/news/fecal-transplant-stem-cells-may-help-crohns-disease/ cbs news fecal transplant, stem cells may help crohn's disease

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