Congenital rubella syndrome

Congenital rubella syndrome

Last Reviewed : 12/25/2020
Congenital rubella syndrome

Congenital rubella syndrome (CRS) can occur in a developing fetus of a pregnant woman who has contracted rubella, usually in the first trimester. If infection occurs 0–28 days before conception, the infant has a 43% chance of being affected. If the infection occurs 0–12 weeks after conception, the chance increases to 51%. If the infection occurs 13–26 weeks after conception, the chance is 23% of the infant being affected by the disease. Infants are not generally affected if rubella is contracted during the third trimester, or 26–40 weeks after conception. Problems rarely occur when rubella is contracted by the mother after 20 weeks of gestation and continues to disseminate the virus after birth.

It was discovered in 1941 by Australian Norman McAlister Gregg.

The molecular basis for the causation of congenital rubella syndrome are not yet completely clear, but in vitro studies with cell lines showed that rubella virus has an apoptotic effect on certain cell types. There is evidence for a p53-dependent mechanism.


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Basic information: congenital rubella syndrome congenital rubella syndrome congenital rubella syndrome congenital rubella syndrome congenital rubella syndrome congenital rubella syndrome congenital rubella syndrome


Advanced information: congenital rubella syndrome congenital rubella syndrome world health organisation congenital rubella syndrome congenital rubella syndrome congenital rubella syndrome congenital rubella syndrome congenital rubella syndrome unprotected people reports: rubella infant dies of congenital rubella syndrome sogc clinical practice guidelines rubella in pregnancy no. 203, february 2008 congenital rubella syndrome neuropsychological functioning and implications illustrated by a case study by jude nicholas, clinical psychologist, norway chapter 15: congenital rubella syndrome by susan reef, md; susan redd vpd surveillance manual, 4th edition, 2008 congenital rubella syndrome: chapter 15-1


Research: control of rubella and congenital rubella syndrome (crs) in developing countries, part 1:burden of disease from crs by f.t. Cutts et al., bulletin of the world health organization, 1997, 75 (1): 55-68 congenital rubella syndrome author: doctor elisabeth robert-gnansia robert-gnansia e, congenital rubella syndrome. Orphanet encyclopedia, november 2004

Vijayalakshmi p, kakkar g, samprathi a, banushree r. Ocular manifestations of congenital rubella syndrome in a developing country. Indian j ophthalmol [serial online] 2002 [cited 2016 may 4];50:307-11. Available from: rev panam salud publica vol.14 n.5 washington nov. 2003 special report : rubella and congenital rubella syndrome: global update by susan e. Robertson et al., congenital rubella syndrome in iran by jila sadighi,hasan eftekhar andkazem mohammad bmc infectious diseasesbmc series ¿ open, inclusive and trusted20055:44 doi: 10.1186/1471-2334-5-44 congenital rubella syndrome and autism spectrum disorder prevented by rubella vaccination - united states, 2001-2010 by brynn e berger,ann marie navar-boggan and saad b omer bmc public healthbmc series – open, inclusive and trusted201111:340 doi: 10.1186/1471-2458-11-340 passive immunisation (giving antibodies) for preventing rubella (german measles) after contact with it by young mk, cripps aw, nimmo gr, van driel m cochrane elimination of endemic measles, rubella, and congenital rubella syndrome from the western hemispherethe us experience by mark j. Papania, md, mph et al.,jjama pediatr. 2014;168(2):148-155. Doi:10.1001/jamapediatrics.2013.4342 congenital rubella syndrome: it still exists in india by satheesh k. Bhandary et al., journal of clinical and diagnostic research. 2012 april, vol-6(2): 301-302 elimination of rubella and congenital rubella syndrome in the americas by carlos castillo-solórzano et al., j infect dis. (2011) 204 (suppl 2):s571-s578.doi: 10.1093/infdis/jir472 burden of congenital rubella syndrome (crs) in india: a systematic review by pooja dewan and piyush gupta journal of tropical medicine
volume 2013 (2013), article id 956234, 5 pages research article:congenital rubella syndrome in fiji, 1995–2010 by sheetalpreet singh et al. pathogenesis of congenital rubella virus infection in human fetuses: viral infection in the ciliary body could play an important role in cataractogenesis by thong van nguyen et al., ebiomedicine volume 2, issue 1, january 2015, pages 59–63 doi:10.1016/j.ebiom.2014.10.021 images in cardiovascular medicine:congenital rubella syndrome presenting in adulthood with fatigue by varun gupta, md et al., circulation.2013; 128: 2542-2545doi: 10.1161/circulationaha.113.001955 congenital rubella syndromedmajor review by robert s. Duszak, o.d. Optometry (2009) 80, 36-43 teratogen update: congenital rubella by william s. Webster teratology 58:13–23 (1998) challenges for congenital rubella syndrome by dr. D. S. Divekar et al., anestesia pediatrica e neonatale,vol.10,n.2,november-december 2012 j. Pediatr. (rio j.) Vol.83 no.5 porto alegre sept./oct. 2007 original article: impact of rubella vaccination strategy on the occurrence of congenital rubella syndrome by tatiana miranda lanzieri et al., journal of immunology and infectious diseases volume 2 | issue 1 hydrocephalus in congenital rubella syndrome: a case report by tiwari c et al.

Shetty g, kalyanshetti r, khan hu, hegde p. Blueberry muffin rash at birth due to congenital rubella syndrome. Indian j paediatr dermatol [serial online] 2013 [cited 2016 may 4];14:73-5. Available from:


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