clostridium-difficile-infectionpseudo-membranous-colitis
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Clostridium difficile infection/pseudo membranous colitis

Clostridium difficile infection/pseudo membranous colitis

Last Reviewed : 12/25/2020
Clostridium difficile infection/pseudo membranous colitis

Clostridium difficile colitis or pseudomembranous colitis is colitis (inflammation of the large intestine) resulting from infection with Clostridium difficile, a spore-forming bacterium. It causes an infectious diarrhea called C. difficileassociated diarrhea (CDAD). Latent symptoms of Clostridium difficile infection (CDI) often mimic some flu-like symptoms and may mimic disease flare-ups in people with inflammatory bowel disease–associated colitis. C. difficilereleases toxins that may cause bloating and diarrhea, with abdominal pain, which may become severe.

The colitis is thought to occur when this bacterium replaces normal gut flora that has been compromised, usually following antibiotic treatment for an unrelated infection. The disturbance of normal healthy bacteria may provide C. difficile an opportunity to overrun the intestinal microbiome. It is a type of antibiotic-associated diarrhea.

Often, mild cases of CDI may be treated by discontinuing the offending antibiotics. More serious cases require targeted antibiotic treatment. Relapses of CDI have been reported in up to 20% of cases. C. difficile infection is a growing problem in health care facilities, killing approximately 29,000 people in the United States in 2011.

 

We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.

 

Basic information:

https://www.nlm.nih.gov/medlineplus/clostridiumdifficileinfections.html medline plus clostridium difficile infections

http://www.webmd.com/digestive-disorders/clostridium-difficile-colitis clostridium difficile colitis

http://patients.gi.org/topics/c-difficile-infection/ american college of gastro enterology clostridium difficile infections

http://familydoctor.org/familydoctor/en/diseases-conditions/clostridium-difficile-infection.printerview.all.html family doctor.org clostridium difficile infections

http://www.mayoclinic.org/diseases-conditions/c-difficile/basics/definition/con-20029664 clostridium difficile ,definition

http://www.nhs.uk/conditions/clostridium-difficile/pages/introduction.aspx clostridium difficile infections

http://www.medicalnewstoday.com/articles/172329.php mnt clostridium difficile infections

http://www.openbiome.org/about-cdiff/ open biome about clostridium difficile infections

http://www.bupa.co.uk/health-information/directory/c/clostridium-difficile-infection bupa clostridium difficile infections

https://www.vdh.virginia.gov/epidemiology/surveillance/hai/cdiff.htm virginia dept of health clostridium difficile

http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/infectious-disease/clostridium-difficile-infection/ clostridium difficile infections

http://www.msdmanuals.com/professional/infectious-diseases/anaerobic-bacteria/clostridium-difficile-%e2%80%93induced-diarrhea clostridium difficile –induced diarrhea (pseudomembranous colitis)

http://www.sahealth.sa.gov.au/wps/wcm/connect/public+content/sa+health+internet/health+topics/health+conditions+prevention+and+treatment/infectious+diseases/clostridium+difficile+infection+cdisa health clostridium difficile infection (cdi) - including symptoms, treatment and prevention

 

Advanced information:

http://patient.info/health/clostridium-difficile-leaflet patient clostridium difficile

http://www.phac-aspc.gc.ca/id-mi/cdiff-eng.php public health agency of canada fact sheet clostridium difficile infections

http://www.medicinenet.com/clostridium_difficile_colitis/article.htm medicine met.com clostridium difficile infections

http://emedicine.medscape.com/article/186458-overview medscape clostridium difficile infections

http://www.cdd.com.au/pages/disease_info/clostridium_difficle.html center with digestive diseases clostridium difficile infections

https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/321891/clostridium_difficile_management_and_treatment.pdfupdated guidance on the management and treatment of clostridium difficile infection

http://www.uptodate.com/contents/antibiotic-associated-diarrhea-caused-by-clostridium difficile-beyond-the-basicspatient information: antibiotic-associated diarrhea caused by clostridium difficile (beyond the basics)

https://www.fascrs.org/sites/default/files/downloads/publication/practice_parameter_clostridium_difficile_infection.pdfpractice parameters for the management of clostridium difficile infection scott r. Steele, m.d et al dis colon rectum 2015; 58: 10–24 doi: 10.1097/dcr.0000000000000289

http://www.health.gov.on.ca/en/pro/programs/publichealth/oph_standards/docs/cdi_chapter.pdf appendix a: disease-specific chapters chapter: clostridium difficile infection (cdi) outbreaks in public hospitals infectious disease protocol

http://www.safetyandquality.gov.au/wp-content/uploads/2015/05/surveillance-and-monitoring-of-cdi-in-australia-april-2015.pdf consultation on surveillance and monitoring of clostridium difficile infection in australia australian commission on safety and quality in health care

http://www.hpsc.ie/a-z/gastroenteric/clostridiumdifficile/guidelines/file,13951,en.pdf surveillance, diagnosis and management of clostridium difficile infection in ireland national clinical guideline no. 3 national clinical effectiveness committee (ncec) clostridium difficile infection in ireland

 

Research:

Gupta v, garg r. Probiotics. Indian j med microbiol [serial online] 2009 [cited 2016 may 26];27:202-9. Available from: http://www.ijmm.org/text.asp?2009/27/3/202/53201

http://gutpathogens.biomedcentral.com/articles/10.1186/1757-4749-3-16 bacillus coagulans gbi-30 (bc30) improves indices of clostridium difficile-induced colitis in mice by leo r fitzpatrick et al., gut pathogens20113:16 doi: 10.1186/1757-4749-3-16

http://cid.oxfordjournals.org/content/46/supplement_1/s12.long clinical recognition and diagnosis ofclostridium difficile infection john g. Bartlett and dale n. Gerding clin infect dis. (2008) 46(supplement 1): s12-s18.doi: 10.1086/521863

https://aricjournal.biomedcentral.com/articles/10.1186/2047-2994-2-21 epidemiology of clostridium difficile infection in asia by deirdre a collins,peter m hawkey and thomas v rileyantimicrobial resistance and infection control20132:21 doi: 10.1186/2047-2994-2-21

 

Related videos:

https://www.youtube.com/watch?v=rt-sm9fldh4 clostridium difficile

https://www.youtube.com/watch?v=zwetpvtbizy clostridium difficile or “c. Diff” - how it spreads, symptoms & prevention

https://www.youtube.com/watch?v=r5ks8cdagr0 clostridium difficile toxins

https://www.youtube.com/watch?v=xubxodqxvg0 clostridium difficile

https://www.youtube.com/watch?v=j9j8rqg2j2q medical school - clostridium difficile infection

https://www.youtube.com/watch?v=dv9nxhnlmts cliff and c. Diff - smelling the diagnosis

 

Presentations/quiz/newspaper articles:

http://www.healio.com/infectious-disease/gastrointestinal-infections/news/online/%7b599823d6-0789-4b85-88f4-7e47cc63ba39%7d/probiotics-reduce-c-difficile-infection-risk-in-hospitalized-patients-taking-antibiotics probiotics reduce c. Difficile infection risk in hospitalized patients taking antibiotics

http://www.huffingtonpost.com/news/clostridium-difficile-infection/ hospitals fail to take simple measures to thwart deadly c. Diff, survey says

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