Clostridium difficile infection/pseudo membranous colitis

Clostridium difficile infection/pseudo membranous colitis

Last Reviewed : 12/25/2020
Clostridium difficile infection/pseudo membranous colitis

Clostridium difficile colitis or pseudomembranous colitis is colitis (inflammation of the large intestine) resulting from infection with Clostridium difficile, a spore-forming bacterium. It causes an infectious diarrhea called C. difficileassociated diarrhea (CDAD). Latent symptoms of Clostridium difficile infection (CDI) often mimic some flu-like symptoms and may mimic disease flare-ups in people with inflammatory bowel disease–associated colitis. C. difficilereleases toxins that may cause bloating and diarrhea, with abdominal pain, which may become severe.

The colitis is thought to occur when this bacterium replaces normal gut flora that has been compromised, usually following antibiotic treatment for an unrelated infection. The disturbance of normal healthy bacteria may provide C. difficile an opportunity to overrun the intestinal microbiome. It is a type of antibiotic-associated diarrhea.

Often, mild cases of CDI may be treated by discontinuing the offending antibiotics. More serious cases require targeted antibiotic treatment. Relapses of CDI have been reported in up to 20% of cases. C. difficile infection is a growing problem in health care facilities, killing approximately 29,000 people in the United States in 2011.


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Basic information: medline plus clostridium difficile infections clostridium difficile colitis american college of gastro enterology clostridium difficile infections family clostridium difficile infections clostridium difficile ,definition clostridium difficile infections mnt clostridium difficile infections open biome about clostridium difficile infections bupa clostridium difficile infections virginia dept of health clostridium difficile clostridium difficile infections clostridium difficile –induced diarrhea (pseudomembranous colitis) health clostridium difficile infection (cdi) - including symptoms, treatment and prevention


Advanced information: patient clostridium difficile public health agency of canada fact sheet clostridium difficile infections medicine clostridium difficile infections medscape clostridium difficile infections center with digestive diseases clostridium difficile infections guidance on the management and treatment of clostridium difficile infection difficile-beyond-the-basicspatient information: antibiotic-associated diarrhea caused by clostridium difficile (beyond the basics) parameters for the management of clostridium difficile infection scott r. Steele, m.d et al dis colon rectum 2015; 58: 10–24 doi: 10.1097/dcr.0000000000000289 appendix a: disease-specific chapters chapter: clostridium difficile infection (cdi) outbreaks in public hospitals infectious disease protocol consultation on surveillance and monitoring of clostridium difficile infection in australia australian commission on safety and quality in health care,13951,en.pdf surveillance, diagnosis and management of clostridium difficile infection in ireland national clinical guideline no. 3 national clinical effectiveness committee (ncec) clostridium difficile infection in ireland



Gupta v, garg r. Probiotics. Indian j med microbiol [serial online] 2009 [cited 2016 may 26];27:202-9. Available from: bacillus coagulans gbi-30 (bc30) improves indices of clostridium difficile-induced colitis in mice by leo r fitzpatrick et al., gut pathogens20113:16 doi: 10.1186/1757-4749-3-16 clinical recognition and diagnosis ofclostridium difficile infection john g. Bartlett and dale n. Gerding clin infect dis. (2008) 46(supplement 1): s12-s18.doi: 10.1086/521863 epidemiology of clostridium difficile infection in asia by deirdre a collins,peter m hawkey and thomas v rileyantimicrobial resistance and infection control20132:21 doi: 10.1186/2047-2994-2-21


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Presentations/quiz/newspaper articles: probiotics reduce c. Difficile infection risk in hospitalized patients taking antibiotics hospitals fail to take simple measures to thwart deadly c. Diff, survey says

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