churg-strauss-syndrome
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Churg strauss syndrome

Churg strauss syndrome

Last Reviewed : 12/24/2020
Churg strauss syndrome

Eosinophilic granulomatosis with polyangiitis (EGPA; also known as Churg-Strauss syndrome [CSS] or allergic granulomatosis) is a rare autoimmune condition that causes inflammation of small and medium-sized blood vessels (vasculitis) in persons with a history of airway allergic hypersensitivity (atopy).

It usually manifests in three stages. The early (prodromal) stage is marked by airway inflammation; almost all patients experience asthma and/or allergic rhinitis. The second stage is characterized by abnormally high numbers of eosinophils (hypereosinophilia), which causes tissue damage, most commonly to the lungs and the digestive tract. The third stage consists of vasculitis, which can eventually lead to cell death and can be life-threatening.

This condition is now called "eosinophilic granulomatosis with polyangiitis" to remove all eponyms from the vasculitides. To facilitate the transition, it was referred to as "eosinophilic granulomatosis with polyangiitis (Churg-Strauss)" for a period of time starting in 2012. Prior to this it was known as "Churg-Strauss syndrome", named after Drs. Jacob Churg and Lotte Strausswho, in 1951, first published about the syndrome using the term "allergic granulomatosis" to describe it. It is a type ofsystemic necrotizing vasculitis.

Effective treatment of EGPA requires suppression of the immune system with medication. This is typically glucocorticoids, followed by other agents such as cyclophosphamide or azathioprine.

 

We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.

 

Basic information:

Http://www.mayoclinic.org/home/ovc-20232243 mayoclinic churg-strauss syndrome

Http://www.webmd.com/rheumatoid-arthritis/churg-strauss-syndrome#1 web md what is churg-strauss syndrome?

Http://www.vasculitis.org.uk/about-vasculitis/churg-strauss-syndrome vasculitis.org churg-strauss syndrome

Http://www.aaaai.org/conditions-and-treatments/related-conditions/churg-strauss-syndrome american academy of allergy,asthma and immunology churg-strauss syndrome

Http://my.clevelandclinic.org/health/articles/churg-strauss-syndrome cleveland clinic churg-strauss syndrome

Http://www.orpha.net/consor/cgi-bin/oc_exp.php?Lng=en&expert=183 orphanet churg-strauss syndrome

 

Advanced information:

Http://emedicine.medscape.com/article/333492-overview medscape eosinophilic granulomatosis with polyangiitis (churg-strauss syndrome)

Http://www.medicinenet.com/churg-strauss_syndrome/article.htm medicine net churg-strauss syndrome

Https://rarediseases.org/rare-diseases/churg-strauss-syndrome/ national organisation for rare diseases churg-strauss syndrome

Http://patient.info/in/doctor/churg-strauss-syndrome-pro patient churg-strauss syndrome

Http://www.dermnetnz.org/topics/eosinophilic-granulomatosis-with-polyangiitis/ derm net nz churg-strauss syndrome

Https://radiopaedia.org/articles/eosinophilic-granulomatosis-with-polyangiitis radiopedia eosinophilic granulomatosis with polyangiitis

Http://www.fpnotebook.com/lung/ild/chrgstrssyndrm.htm family practise notebook churg-strauss syndrome

 

Research:

Https://www.ncbi.nlm.nih.gov/pmc/articles/pmc4337121/ fernandes gl, teixeira aa, antón ags, reis atr, de freitas acr, basílio db. Churg-strauss syndrome: a case report . Radiologia brasileira. 2014;47(4):259-261. Doi:10.1590/0100-3984.2013.1817.

Http://thorax.bmj.com/content/55/9/805.full thorax 2000;55:805-806 doi:10.1136/thorax.55.9.805 case report:churg-strauss syndrome associated with montelukast therapy by j m tuggey, h s r hosker

Http://www.nature.com/modpathol/journal/v14/n12/full/3880475a.html mod pathol 2001;14(12):1284–1293 recent advances in the diagnosis of churg-strauss syndrome by andrew churg m.d.

Http://www.scielo.br/scielo.php?Pid=s0100-39842014000400014&script=sci_arttext&tlng=en radiol bras vol.47 no.4 são paulo jul./aug. 2014 http://dx.doi.org/10.1590/0100-3984.2013.1817 case reports churg-strauss syndrome: a case report* by gabriel lacerda fernandes et al.,

Http://www.ajnr.org/content/23/2/221.full intracranial meningeal involvement in churg-strauss syndrome by aya m. Tokumaru et al., ajnr 2002 23: 221-224

Http://err.ersjournals.com/content/21/123/75 asymptomatic bilateral pulmonary embolism in churg–strauss syndrome by a. Maria et al, european respiratory review 2012 21: 75-77; doi: 10.1183/09059180.00007911

Raina s, kaul r, kaur n, chauhan ns. Eosinophilic granulomatosis with polyangitis (churg-strauss syndrome): a diagnostic rarity with an atypical presentation. Egypt rheumatol rehabil [serial online] 2014 [cited 2016 dec 29];41:187-9. Available from: http://www.err.eg.net/text.asp?2014/41/4/187/147363

Http://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/1471-2474-15-388 eosinophilic granulomatosis with polyangiitis (churg-strauss syndrome) presenting as diffuse myositis by marc-etienne parent et al., bmc musculoskeletal disorders201415:388 doi: 10.1186/1471-2474-15-388

Https://www.hindawi.com/journals/crie/2013/415810/ russell senanayake and mamoun mukhtar, “cotrimoxazole-induced hypoglycaemia in a patient with churg-strauss syndrome,” case reports in endocrinology, vol. 2013, article id 415810, 3 pages, 2013. Doi:10.1155/2013/415810

Https://www.hindawi.com/journals/crihep/2011/412524/ keiji matsui and kosuke nishijima, “a case of montelukast-induced churg-strauss syndrome associated with liver dysfunction,” case reports in hepatology, vol. 2011, article id 412524, 4 pages, 2011. Doi:10.1155/2011/412524

Https://www.hindawi.com/journals/cripu/2014/673906/ kamal kishore pandita, khalid javid bhat, sushil razdan, and r. P. Kudyar, ““peripheral neuropathy crippling bronchial asthma”: two rare case reports of churg-strauss syndrome,” case reports in pulmonology, vol. 2014, article id 673906, 3 pages, 2014. Doi:10.1155/2014/673906

Brar b k, mehta v, chopra d, kubba a. Churg-strauss syndrome. Indian j dermatol [serial online] 2009 [cited 2016 dec 29];54, suppl s1:76-7. Available from: http://www.e-ijd.org/text.asp?2009/54/5/76/45465

Http://jmedicalcasereports.biomedcentral.com/articles/10.1186/1752-1947-4-188 churg-strauss syndrome following cessation of allergic desensitization vaccination: a case report by mohammad reza masjedi et al., journal of medical case reports20104:188 doi: 10.1186/1752-1947-4-188

Kamata y, hashizume k, kaneko m, kurosaka d. A case of churg-strauss syndrome and central retinal artery occlusion with good visual recovery. Indian j ophthalmol [serial online] 2013 [cited 2016 dec 29];61:178-9. Available from: http://www.ijo.in/text.asp?2013/61/4/178/112164

Https://www.hindawi.com/journals/ijr/2009/504105/ r. A. M. Quax, a. J. G. Swaak, and m. G. A. Baggen, “churg-strauss syndrome following ptu treatment,”international journal of rheumatology, vol. 2009, article id 504105, 4 pages, 2009. Doi:10.1155/2009/504105

 

 

Other helpful resources(support groups):

Http://www.vasculitisfoundation.org/education/forms/eosinophilic-granulomatosis-with-polyangiitis-churg-strauss-syndrome/ eosinophilic granulomatosis with polyangiitis (egpa/churg-strauss syndrome)

Http://www.cssassociation.org/

Http://www.thelaurencurrietwilightfoundation.org/blog/tag/churg-strauss-syndrome/ vasculitis awareness and research

 

Related videos:

Https://www.khanacademy.org/science/health-and-medicine/circulatory-system-diseases/vasculitis/v/churg-strauss-syndrome churg-strauss syndrome

Https://www.youtube.com/watch?V=de7as-hpwko churg-strauss syndrome | circulatory system and disease | nclex-rn | khan academy

Https://www.youtube.com/watch?V=fffrrkgcrky churg strauss syndrome - animated quick review

Https://www.youtube.com/watch?V=7uoykel9yvs usmle: what you need to know about churg strauss syndrome by usmleteam

Https://www.youtube.com/watch?V=jrnygioy3wu churg strauss syndrome (rex liu, md)

Https://www.youtube.com/watch?V=i1iyl51sp8k 53__chapter two: churg strauss vasculitis, with dr. Carol a. Langford and lynn corwin

 

 

Presentations/quiz/newspaper articles:

Https://globalgenes.org/raredaily/toni-street-suffering-from-churg-strauss-syndrome/ toni street suffering from churg-strauss syndrome

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