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Chronic myeloid leukemia/ chronic granulocytic leukemia/ chronic myelogenous leukemia, cml

Chronic myeloid leukemia/ chronic granulocytic leukemia/ chronic myelogenous leukemia, cml

Last Reviewed : 12/24/2020
Chronic myeloid leukemia/ chronic granulocytic leukemia/ chronic myelogenous leukemia, cml

Chronic myeloid leukemia is a cancer of the white blood cells. It is a form of leukemia characterized by the increased and unregulated growth of predominantly myeloid cells in the bone marrow and the accumulation of these cells in the blood. It is a type of myeloproliferative disease associated with a characteristic chromosomal translocation called the Philadelphia chromosome. CML is now largely treated with targeted drugs called tyrosine kinase inhibitors (TKIs) which have led to dramatically improved long-term survival rates since the introduction of the first such agent in 2001. These drugs have revolutionized treatment of this disease and allow most patients to have a good quality of life when compared to the former chemotherapy drugs. In Western countries, CML accounts for 15-20% of all adult leukemias and 14% of leukemias overall (including the pediatric population).

 

We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.


Basic information

http://patient.info/doctor/chronic-myeloid-leukaemia-pro. Patient, chronic myeloid leukaemia
 

http://www.merckmanuals.com/professional/hematology-and-oncology/leukemias/chronic-myelogenous-leukemia-cml. Merck manual, chronic myelogenous leukemia (cml)

http://emedicine.medscape.com/article/199425-overview. Medscape, chronic myelogenous leukemia (cml)

http://www.webmd.com/cancer/lymphoma/cml-need-to-know-first. Webmd, leukemia & lymphoma
 

http://www.mayoclinic.org/diseases-conditions/chronic-myelogenous-leukemia/home/ovc-20202048. Mayoclinic, chronic myelogenous leukemia
 

http://www.healthline.com/health/chronic-myeloid-leukemia. Healthline, what is chronic myeloid leukemia?
 

https://www.nlm.nih.gov/medlineplus/ency/article/000570.htm. Medline plus, chronic myelogenous leukemia (cml)
 

http://www.cancer.net/cancer-types/leukemia-chronic-myeloid-cml. Cancer.net leukemia - chronic myeloid – cml

http://www.cancer.gov/types/leukemia/patient/cml-treatment-pdq. Nih, national cancer institute, chronic myelogenous leukemia

http://www.cancercouncil.com.au/chronic-myeloid-leukaemia/. Cancer council nsw, is chronic myeloid leukemia?

Advanced information

http://www.esmo.org/guidelines/haematological-malignancies/chronic-myeloid-leukemia. Chronic myeloid leukemia: esmo clinical practice guidelines

http://www.omim.org/entry/608232. Omim, leukemia, chronic myeloid; cml

http://www.scielo.br/scielo.php?pid=s0104-42302013000300006&script=sci_arttext&tlng=en. Scielo, chronic myeloid leukemia
 

http://ehoonline.biomedcentral.com/articles/10.1186/2162-3619-2-5. Biomed central, the relative efficacy of imatinib, dasatinib and nilotinib for newly diagnosed chronic myeloid leukemia: a systematic review and network meta-analysis

Experimental hematology & oncology20132:5

Doi: 10.1186/2162-3619-2-5



research

http://bmcmedicine.biomedcentral.com/articles/10.1186/1741-7015-9-99. Biomed central, advances in the treatment of chronic myeloid leukemia
 

http://www.futuremedicine.com/doi/book/10.2217/9781780842738. Future medicine, advances in the treatment of chronic myeloid leukemia

http://www.sciencedirect.com/science/article/pii/s2212137415200188. Science direct, receptor tyrosine kinases: characterisation, mechanism of action and therapeutic interests for bone cancers

journal of bone oncology. 2015;4(1)1-12 doi 10.1016/j.jbo.2015.01.001
 

http://jmedicalcasereports.biomedcentral.com/articles/10.1186/1752-1947-1-121. Biomed central, minimal change nephrotic syndrome after stem cell transplantation: a case report and literature review, journal of medical case reports20071:121

Doi: 10.1186/1752-1947-1-121

http://www.mjhid.org/index.php/mjhid/index. Mediterranean journal of hematology and infectious diseases,

http://www.mdpi.com/2227-9067/2/2/146. Secondary malignant neoplasms following haematopoietic stem cell transplantation in childhood, children 2015, 2(2), 146-173; doi:10.3390/children2020146


other articles

http://www.cancerresearchuk.org/about-cancer/type/cml/. Cancer research uk, chronic myeloid leukaemia (cml)

http://www.biology-pages.info/c/cml.html. Chronic myelogenous leukemia (cml)


http://atlasgeneticsoncology.org/anomalies/acmlid2117.html. Atlas of genetics and cytogenetics in oncology and haematology, atypical chronic myeloid leukemia (acml)



other related articles
http://www.genome.jp/kegg-bin/show_pathway?hsa05220. Kegg, chronic myeloid leukemia

https://www.mycancergenome.org/content/disease/chronic-myeloid-leukemia/bcr-abl1. My cancer genome, bcr-abl1 in chronic myeloid leukemia

https://www.nccn.org/patients/guidelines/cml/. Nccn guidelines


https://www.dnalc.org/view/15994-the-chronic-myeloid-leukemia-cml-mutation.html. Dna learning center the chronic myeloid leukemia (cml) mutation




other helpful resources

http://www.leukaemia.org.au/blood-cancers/leukaemias/chronic-myeloid-leukaemia-cml. Leukaemia foundation, chronic myeloid leukaemia (cml)

http://www.macmillan.org.uk/cancerinformation/cancertypes/leukaemiachronicmyeloid/cml.aspx. Macmillan support, chronic myeloid leukaemia (cml)

http://www.cmlsupport.org.uk/. Cml support

https://www.cml-foundation.org/. International chronic myeloid leukemia foundation (icmlf)

http://www.cmladvocates.net/. Cml advocates


related videos

http://www.cancercenter.com/leukemia/types/tab/chronic-myeloid-leukemia/. Cancer center, chronic myeloid leukaemia (cml)


https://www.youtube.com/watch?v=d2ijpav65mg. Youtube, chronic myelogenous leukemia

https://www.youtube.com/watch?v=st6msb-rve0. Youtube, khan academy medicine, chronic myelogenous leukemia

https://www.youtube.com/watch?v=ut4pngxfbiu. Youtube, leukemia cancer, chronic myelogenous leukemia

https://www.youtube.com/watch?v=mgqyy57utvu. Youtube, mayo clinic, chronic myeloid leukemia


presentation/quiz/newspaper

http://www.nejm.org/doi/full/10.1056/nejmoa022457#t=articlediscussion. The new england journal of medicine, imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
 

https://www.jci.org/articles/view/41246. Journal of clinical investigation, chronic myeloid leukemia: mechanisms of blastic transformation
 

http://www.gcsmc.org/download/journal/2013_2/2.pdf. Chronic myeloid leukemia in children, patel et al.gcsmc, j med sci vol(ii) no (ii)


http://www.sciencedirect.com/science/article/pii/s2221618915000402. Sciencedirect, diagnosis of chronic myeloid leukemia from acute intracerebral hemorrhage: a case report, http://dx.doi.org/10.1016/j.joad.2015.03.004

http://www.bcshguidelines.com/documents/cml_bcr-abl_270707.pdf. Recommendation for management of bcr-abl positive cml

http://blog.sciencenet.cn/upload/blog/file/2009/7/20097198916820310.pdf. Cml, a case report, y. –x ru et al. Doi: 10. 1080/01913120902786961

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