Choriocarcinoma is a malignant, trophoblastic cancer, usually of the placenta, that arises from trophoblastic cells within the uterus. It tends to be invasive and to metastasize early and widely through both the venous and lymphatic systems. It belongs to the malignant end of the spectrum in gestational trophoblastic disease (GTD). It is also classified as a germ cell tumor and may arise in the testis or ovary. Choriocarcinoma may follow any type of pregnancy, especially likely to occur with a hydatidiform mole (molar pregnancy). About 2 to 3% of hydatidiform moles are complicated by the development of choriocarcinoma. The prognosis has markedly improved with the advent of multidrug chemotherapy. Overall, the cure rate for high-risk patients is 60 to 80%.
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