Barrett's oesophagus

Barrett's oesophagus

Last Reviewed : 12/24/2020
Barrett's oesophagus

Barrett's esophagus (British English: Barrett's oesophagus), sometimes called Barrett syndrome, Barrett esophagus, or columnar epithelium lined lower oesophagus (CELLO), refers to an abnormal change (metaplasia) in the cells of the lower portion of the esophagus. It is characterized by the replacement of the normal stratified squamous epithelium lining of the esophagus by simple columnar epithelium with goblet cells (which are usually found lower in the gastrointestinal tract). The medical significance of Barrett's esophagus is its strong association (about 0.5% per patient-year) with esophageal adenocarcinoma, a very often deadly cancer, because of which it is considered to be a premalignant condition.

The main cause of Barrett's esophagus is thought to be an adaptation to chronic acid exposure from reflux esophagitis. The incidence of esophageal adenocarcinoma has increased substantially in the Western world in recent years. The condition is found in 5–15% of patients who seek medical care for heartburn (gastroesophageal reflux disease), although a large subgroup of patients with Barrett's esophagus do not have symptoms.[1] Diagnosis requires endoscopy (more specifically, esophagogastroduodenoscopy, a procedure in which a fibreoptic cable is inserted through the mouth to examine the esophagus, stomach, and duodenum) andbiopsy. The cells of Barrett's esophagus, after biopsy, are classified into four general categories: nondysplastic, low-grade dysplasia, high-grade dysplasia, and frank carcinoma. High-grade dysplasia and early stages of adenocarcinoma can be treated by endoscopic resection and new endoscopic therapies such as radiofrequency ablation, whereas advanced stages (submucosal) are generally advised to undergo surgical treatment. Nondysplastic and low-grade patients are generally advised to undergo annual observation with endoscopy, with radiofrequency ablation as a therapeutic option. In high-grade dysplasia, the risk of developing cancer might be at 10% per patient-year or greater.

The condition is named after the Australian-born British thoracic surgeon Norman Barrett (1903–1979), who described it in 1950.


We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.


Basic information: barrett's esophagus: symptoms, causes, and treatments barrett's oesophagus barrett's oesophagus barrett's oesophagus barrett's oesophagus american society for gastro intestinal endoscopy barrett's oesophagus's oesophagus barrett's oesophagus barrett's oesophagus's-esophagus.html barrett's oesophagus barrett's oesophagus disease digestive center barrett's oesophagus barrett's oesophagus virginia mason barrett's oesophagus barrett's oesophagus barrett's oesophagus's-esophagus.aspx barrett's esophagus and esophageal cancer


Advanced information: barrett esophagus treatment & management barrett's oesophagus barrett's oesophagus barrett's oesophagus barrett's oesophagus barrett's oesophagus disease digestive center temple university hospital barrett's oesophagus university of washington barrett's oesophagus pathology aetna barrett's oesophagus american gastroenterological association medical position statement on the management of barrett’s esophagus gastroenterology 2011;140:1084 –1091 doi:10.1053/j.gastro.2011.01.030 advocate illinois masonic medical center radiofrequency ablation therapy for barrett’s esophagus cameron aj. epidemiology of barrett’s esophagus and adenocarcinoma. diseases of the esophagus. 2002;15:106–108. current management of barrett’s oesophagus by sharif a anwar, senthooran kathirgama kanthan and amjid ali riaz bjmp 2009:2(4) 8-14 barrett's oesophagus barrett's oesophagus


Research: radiofrequency ablation in barrett's esophagus with dysplasia by nicholas j. shaheen, m.d., m.p.h et al., n engl j med 2009; 360:2277-2288may 28, 2009doi: 10.1056/nejmoa0808145 the association between alcohol and reflux esophagitis, barrett's esophagus, and esophageal adenocarcinoma by lesley a. anderson et al., the association between alcohol and reflux esophagitis, barrett's esophagus, and esophageal adenocarcinoma by anderson, lesley a. et al. gastroenterology , volume 136 , issue 3 , 799 – 805 barrett’s esophagus by mark d. shalauta, m.d., university of california, san diego, school of medicine, san diego, california am fam physician. 2004 may 1;69(9):2113-2118.

dietz judite, chaves-e-silva sílvia, meurer luíse, sekine setsuo, souza andréa ribeiro de, meine gilmara coelho. short segment barrett's esophagus and distal gastric intestinal metaplasia. arq. gastroenterol. [internet]. 2006 june [cited 2016 may 14] ; 43( 2 ): 117-120. available from: &lng=en. barrett's oesophagus and adenocarcinoma by christine pj caygill et al..,world journal of surgical oncology20042:12 doi: 10.1186/1477-7819-2-12 acg clinical guideline: diagnosis and management of barrett’s esophagus by nicholas j. shaheen , md, mph, facg am j gastroenterol advance online publication, 3 november 2015; doi: 10.1038/ajg.2015.322 endoscopic risk factors for neoplastic progression in patients with barrett’s oesophagus by angela bureo gonzalez et al., published online before print march 2, 2016, doi:10.1177/2050640616635509united european gastroenterology journal march 2, 20162050640616635509 diagnosis and treatment of barrett's oesophagus by yean cheant lim and rebecca c. fitzgerald br med bull (2013) 107 (1): 117-132.doi: 10.1093/bmb/ldt025 gastroenterology research and practice
volume 2014 (2014), article id 408470, 6 pages research article:influence of life style factors on barrett’s oesophagus by a. horna strand and t. franzén west indian med. j. vol.55 no.3 mona june 2006 original articles: a caribbean perspective on barretts oesophagus by np williams microrna-196a & microrna-101 expression in barrett's oesophagus in patients with medically and surgically treated gastro-oesophageal reflux by sebastien haiart et al.,bmc research notes20114:41 doi: 10.1186/1756-0500-4-41 exercise and the prevention of oesophageal cancer (epoc) study protocol: a randomized controlled trial of exercise versus stretching in males with barrett's oesophagus by brooke m winzer et al.,bmc cancer201010:292 doi: 10.1186/1471-2407-10-292 activation of akt is increased in the dysplasia-carcinoma sequence in barrett's oesophagus and contributes to increased proliferation and inhibition of apoptosis: a histopathological and functional study by ian lp beales et albmc cancer20077:97 doi: 10.1186/1471-2407-7-97 barrett's oesophagus and adenocarcinoma by christine pj caygill et al world journal of surgical oncology20042:12 doi: 10.1186/1477-7819-2-12


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