Barrett's esophagus (British English: Barrett's oesophagus), sometimes called Barrett syndrome, Barrett esophagus, or columnar epithelium lined lower oesophagus (CELLO), refers to an abnormal change (metaplasia) in the cells of the lower portion of the esophagus. It is characterized by the replacement of the normal stratified squamous epithelium lining of the esophagus by simple columnar epithelium with goblet cells (which are usually found lower in the gastrointestinal tract). The medical significance of Barrett's esophagus is its strong association (about 0.5% per patient-year) with esophageal adenocarcinoma, a very often deadly cancer, because of which it is considered to be a premalignant condition.
The main cause of Barrett's esophagus is thought to be an adaptation to chronic acid exposure from reflux esophagitis. The incidence of esophageal adenocarcinoma has increased substantially in the Western world in recent years. The condition is found in 5–15% of patients who seek medical care for heartburn (gastroesophageal reflux disease), although a large subgroup of patients with Barrett's esophagus do not have symptoms.[1] Diagnosis requires endoscopy (more specifically, esophagogastroduodenoscopy, a procedure in which a fibreoptic cable is inserted through the mouth to examine the esophagus, stomach, and duodenum) andbiopsy. The cells of Barrett's esophagus, after biopsy, are classified into four general categories: nondysplastic, low-grade dysplasia, high-grade dysplasia, and frank carcinoma. High-grade dysplasia and early stages of adenocarcinoma can be treated by endoscopic resection and new endoscopic therapies such as radiofrequency ablation, whereas advanced stages (submucosal) are generally advised to undergo surgical treatment. Nondysplastic and low-grade patients are generally advised to undergo annual observation with endoscopy, with radiofrequency ablation as a therapeutic option. In high-grade dysplasia, the risk of developing cancer might be at 10% per patient-year or greater.
The condition is named after the Australian-born British thoracic surgeon Norman Barrett (1903–1979), who described it in 1950.
We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.
Basic information:
http://www.webmd.com/heartburn-gerd/guide/barretts-esophagus-symptoms-causes-and-treatments barrett's esophagus: symptoms, causes, and treatments
http://www.mayoclinic.org/diseases-conditions/barretts-esophagus/basics/definition/con-20027054 barrett's oesophagus
http://www.medicalnewstoday.com/articles/310144.php barrett's oesophagus
https://www.nlm.nih.gov/medlineplus/ency/article/001143.htm barrett's oesophagus
http://www.healthline.com/health/barretts-esophagus barrett's oesophagus
http://www.asge.org/patients/patients.aspx?id=8954 american society for gastro intestinal endoscopy barrett's oesophagus
http://www.cancerresearchuk.org/about-cancer/cancers-in-general/cancer-questions/what-is-barretts-oesophagusbarrett's oesophagus
https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/barretts-oesophagus barrett's oesophagus
http://my.clevelandclinic.org/health/diseases_conditions/hic_barretts_esophagus_qanda/hic_barretts_esophagus barrett's oesophagus
http://www.nytimes.com/health/guides/symptoms/heartburn/barrett's-esophagus.html barrett's oesophagus
https://stanfordhealthcare.org/medical-conditions/digestion-and-metabolic-health/barretts-esophagus.html barrett's oesophagus
http://www.ddc.musc.edu/public/diseases/esophagus/barretts-esophagus.html disease digestive center barrett's oesophagus
http://familydoctor.org/familydoctor/en/diseases-conditions/barretts-esophagus.html barrett's oesophagus
https://www.virginiamason.org/barrettsesophagus virginia mason barrett's oesophagus
http://www.encyclopedia.com/doc/1g2-3405200062.html barrett's oesophagus
http://www.mountsinai.org/patient-care/health-library/diseases-and-conditions/barretts-esophagus#risk barrett's oesophagus
http://www.everydayhealth.com/esophageal-cancer/barrett's-esophagus.aspx barrett's esophagus and esophageal cancer
Advanced information:
http://emedicine.medscape.com/article/171002-treatment barrett esophagus treatment & management
http://www.medicinenet.com/barretts_esophagus/article.htm barrett's oesophagus
http://www.uptodate.com/contents/barretts-esophagus-beyond-the-basics barrett's oesophagus
http://patient.info/health/barretts-oesophagus-leaflet barrett's oesophagus
http://www.orpha.net/consor/cgi-bin/oc_exp.php?lng=gb&expert=1232
http://www.oncolink.org/types/article.cfm?c=133&id=6935 barrett's oesophagus
http://www.wakehealth.edu/gastroenterology/barrett-s-esophagus.htm barrett's oesophagus
http://digestive.templehealth.org/content/barrettsesophagus.htm disease digestive center temple university hospital barrett's oesophagus
http://www.pathology.washington.edu/about/education/barretts/page2.php university of washington barrett's oesophagus pathology
http://www.aetna.com/cpb/medical/data/700_799/0728.html aetna barrett's oesophagus
http://www.gastro.org/practice/medical-position-statements/barretts_mps.pdf american gastroenterological association medical position statement on the management of barrett’s esophagus gastroenterology 2011;140:1084 –1091 doi:10.1053/j.gastro.2011.01.030
http://www.advocatehealth.com/immc-radiofrequency-ablation-therapy-for-barretts-esophagus advocate illinois masonic medical center radiofrequency ablation therapy for barrett’s esophagus
http://www.wvmedical.com/site/content/documents/gi%20handouts/barretts.pdf cameron aj. epidemiology of barrett’s esophagus and adenocarcinoma. diseases of the esophagus. 2002;15:106–108.
http://www.bjmp.org/content/current-management-barrett-s-oesophagus current management of barrett’s oesophagus by sharif a anwar, senthooran kathirgama kanthan and amjid ali riaz bjmp 2009:2(4) 8-14
http://radiopaedia.org/articles/barrett-oesophagus barrett's oesophagus
http://www.bdiap.org/git/2shepherd.htm barrett's oesophagus
Research:
http://www.nejm.org/doi/full/10.1056/nejmoa0808145#t=article radiofrequency ablation in barrett's esophagus with dysplasia by nicholas j. shaheen, m.d., m.p.h et al., n engl j med 2009; 360:2277-2288may 28, 2009doi: 10.1056/nejmoa0808145
http://www.gastrojournal.org/article/s0016-5085(08)02180-x/fulltext the association between alcohol and reflux esophagitis, barrett's esophagus, and esophageal adenocarcinoma by lesley a. anderson et al., the association between alcohol and reflux esophagitis, barrett's esophagus, and esophageal adenocarcinoma by anderson, lesley a. et al. gastroenterology , volume 136 , issue 3 , 799 – 805
http://www.aafp.org/afp/2004/0501/p2113.html barrett’s esophagus by mark d. shalauta, m.d., university of california, san diego, school of medicine, san diego, california am fam physician. 2004 may 1;69(9):2113-2118.
dietz judite, chaves-e-silva sílvia, meurer luíse, sekine setsuo, souza andréa ribeiro de, meine gilmara coelho. short segment barrett's esophagus and distal gastric intestinal metaplasia. arq. gastroenterol. [internet]. 2006 june [cited 2016 may 14] ; 43( 2 ): 117-120. available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=s0004-28032006000200011 &lng=en. http://dx.doi.org/10.1590/s0004-28032006000200011.
http://wjso.biomedcentral.com/articles/10.1186/1477-7819-2-12 barrett's oesophagus and adenocarcinoma by christine pj caygill et al..,world journal of surgical oncology20042:12 doi: 10.1186/1477-7819-2-12
http://www.spg.pt/wp-content/uploads/2015/07/3.-acg-clinical-guideline-diagnosis-and-management-of-barrets-esophagus-nov-2015.pdf acg clinical guideline: diagnosis and management of barrett’s esophagus by nicholas j. shaheen , md, mph, facg am j gastroenterol advance online publication, 3 november 2015; doi: 10.1038/ajg.2015.322
http://ueg.sagepub.com/content/early/2016/03/01/2050640616635509.full endoscopic risk factors for neoplastic progression in patients with barrett’s oesophagus by angela bureo gonzalez et al., published online before print march 2, 2016, doi:10.1177/2050640616635509united european gastroenterology journal march 2, 20162050640616635509
http://bmb.oxfordjournals.org/content/107/1/117.full diagnosis and treatment of barrett's oesophagus by yean cheant lim and rebecca c. fitzgerald br med bull (2013) 107 (1): 117-132.doi: 10.1093/bmb/ldt025
http://www.hindawi.com/journals/grp/2014/408470/ gastroenterology research and practice
volume 2014 (2014), article id 408470, 6 pages http://dx.doi.org/10.1155/2014/408470 research article:influence of life style factors on barrett’s oesophagus by a. horna strand and t. franzén
http://caribbean.scielo.org/scielo.php?pid=s0043-31442006000300004&script=sci_arttext west indian med. j. vol.55 no.3 mona june 2006 http://dx.doi.org/10.1590/s0043-31442006000300004 original articles: a caribbean perspective on barretts oesophagus by np williams
http://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0500-4-41 microrna-196a & microrna-101 expression in barrett's oesophagus in patients with medically and surgically treated gastro-oesophageal reflux by sebastien haiart et al.,bmc research notes20114:41 doi: 10.1186/1756-0500-4-41
http://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-10-292 exercise and the prevention of oesophageal cancer (epoc) study protocol: a randomized controlled trial of exercise versus stretching in males with barrett's oesophagus by brooke m winzer et al.,bmc cancer201010:292 doi: 10.1186/1471-2407-10-292
http://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-7-97 activation of akt is increased in the dysplasia-carcinoma sequence in barrett's oesophagus and contributes to increased proliferation and inhibition of apoptosis: a histopathological and functional study by ian lp beales et albmc cancer20077:97 doi: 10.1186/1471-2407-7-97
http://wjso.biomedcentral.com/articles/10.1186/1477-7819-2-12 barrett's oesophagus and adenocarcinoma by christine pj caygill et al world journal of surgical oncology20042:12 doi: 10.1186/1477-7819-2-12
Related videos:
https://www.youtube.com/watch?v=tq6a4arjfde what is barretts esophagus?-mayo clinic
https://www.youtube.com/watch?v=eqhkbpc59mu barrett's oesophagus
https://www.youtube.com/watch?v=pcpy1zrndqo long barrett's oesophagus
https://www.youtube.com/watch?v=cawu5qv_bms barrett’s esophagus – who, when and how to treat | ucla digestive disease
https://www.youtube.com/watch?v=al_pdgfdrak barrett's oesophagus
https://www.youtube.com/watch?v=wjjwbcvpiva barretts oesophagus
https://www.youtube.com/watch?v=cnxtir6dtbg dr nick musgrave - barrett's oesophagus
https://www.youtube.com/watch?v=nc7cfnd7zge focal cryoballoon ablation system for treatment of barrett's oesophagus
https://www.youtube.com/watch?v=dom0gmyhdx8 histopathology esophagus --barrett esophagus
Presentations/quiz/newspaper articles:
http://indiatoday.intoday.in/story/barretts-esophagus/1/385268.html barrett's esophagus new delhi, september 24, 2014 | updated 00:00 ist