aplastic-anemia
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Aplastic anemia

Aplastic anemia

Last Reviewed : 12/24/2020
Aplastic anemia

Aplastic anemia, also spelled aplastic anaemia, is a rare disease in which the bone marrow and the hematopoietic stem cells that reside there are damaged. This causes a deficiency of all three blood cell types (pancytopenia): red blood cells (anemia), white blood cells (leukopenia), and platelets (thrombocytopenia). Aplastic refers to inability of the stem cells to generate mature blood cells.

It is most prevalent in people in their teens and twenties, but is also common among the elderly. It can be caused by exposure to chemicals, drugs, radiation, immune disease, and heredity. However, in about half the cases, the cause is unknown.

The definitive diagnosis is by bone marrow biopsy; normal bone marrow has 30–70% blood stem cells, but in aplastic anemia, these cells are mostly gone and replaced by fat.

First line treatment for aplastic anemia consists of immunosuppressive drugs, typically either anti-lymphocyte globulin or anti-thymocyte globulin, combined with corticosteroids and ciclosporin. Hematopoietic stem cell transplantation is also used, especially for patients under 30 years of age with a related, matched marrow donor.

 

We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.

 

Basic information:

http://www.mayoclinic.org/diseases-conditions/aplastic-anemia/basics/definition/con-20019296 definition aplastic anemia

http://www.webmd.com/a-to-z-guides/aplastic-anemia aplastic anemia

https://www.nhlbi.nih.gov/health/health-topics/topics/aplastic national heart lung and blood institute aplastic anemia

https://www.nlm.nih.gov/medlineplus/ency/article/000554.htm medline plus aplastic anemia

http://www.hopkinsmedicine.org/kimmel_cancer_center/types_cancer/aplastic_anemia.html johnhopkins medicine aplastic anemia

http://www.healthline.com/health/idiopathic-aplastic-anemia health line aplastic anemia

https://www.msdmanuals.com/professional/hematology-and-oncology/anemias-caused-by-deficient-erythropoiesis/aplastic-anemia msd manuals aplastic anemia

https://labtestsonline.org/understanding/conditions/anemia/start/5 labtests online aplastic anemia

http://www.cumc.columbia.edu/hematology-oncology/patient_care/blood-bone-marrow-transplantation/aplastic-anemiacolumbia university medical center aplastic anemia

http://www.nytimes.com/health/guides/disease/idiopathic-aplastic-anemia/overview.html new york times aplastic anemia

https://my.clevelandclinic.org/health/diseases_conditions/aplastic-anemia aplastic anemia - bone marrow program overview

http://www.stanfordchildrens.org/en/topic/default?id=aplastic-anemia-in-children-90-p02312 aplastic anemia in children

http://www.everydayhealth.com/aplastic-anemia/ aplastic anemia

http://www.mountsinai.org/patient-care/health-library/diseases-and-conditions/aplastic-anemia#treatment aplastic anemia

http://chealth.canoe.com/condition/getcondition/aplastic-anemia aplastic anemia

http://umm.edu/health/medical/ency/articles/idiopathic-aplastic-anemia aplastic anemia

 

Advanced information:

http://emedicine.medscape.com/article/198759-overview aplastic anemia

http://patient.info/doctor/aplastic-anaemia patient aplastic anemia

http://rarediseases.org/rare-diseases/acquired-aplastic-anemia/ nord aplastic anemia

https://www.onkopedia-guidelines.info/en/onkopedia/guidelines/aplastic-anemia-diagnostics-and-therapy-of-acquired-aplastic-anemia/@@view/html/index.html onkopedia guidelines aplastic anemia

http://www.danafarberbostonchildrens.org/conditions/blood-disorders/aplastic-anemia.aspx dana farber,boston childrens cancer and blood disorder center childhood aplastic anemia

http://www.bloodjournal.org/content/bloodjournal/120/6/1185.full.pdf?sso-checked=true how i treat acquired aplastic anemia by phillip scheinberg and neal s. young. blood, 9 august 2012 volume 120, number 6 ; doi 10.1182/blood-2011-12-274019

https://www.kch.nhs.uk/doc/pl%20-%20647.1%20-%20aplastic%20anaemia.pdf king college hospital {nhs} aplastic anaemia

http://www.apiindia.org/pdf/pg_med_2008/chapter-36.pdf aplastic anemia

https://secure.ssa.gov/poms.nsf/lnx/0423022929 di 23022.929 aplastic anemia

http://www.bcshguidelines.com/documents/final_bcsh_aa_guidelines.pdf guidelines for the diagnosis and management of adult aplastic anaemia by sally b. killick et al.

http://www.daviddarling.info/encyclopedia/a/aplastic_anemia.html the world of david darling aplastic anemia

http://pedemmorsels.com/aplastic-anemia/ pediatric em morales aplastic anemia

http://www.cinj.org/sites/cinj/files/documents/december2015aplasticanemiamonth.pdf rutgery cancer institute of new jersy aplastic anemia

http://radiopaedia.org/articles/aplastic-anaemia radiopedia aplastic anemia

https://pedclerk.bsd.uchicago.edu/page/aplastic-anemia pediatric clerkship the university of chicago aplastic anemia

https://www.cibmtr.org/datamanagement/trainingreference/manuals/datamanagement/documents/pre-hsct%20aplastic%20anemia%20data%20form_2028.pdf center for international blood and marrow transplant research center instructions for aplastic anemia pre-hsct data (form 2028)

http://www.isdbweb.org/documents/file/1244_11.pdf the epidemiology of acquired aplastic anemia by neal s. young and david w. kaufman haematologica | 2008; 93(4) doi: 10.3324/haematol.12855

 

Research:

http://www.nejm.org/doi/full/10.1056/nejmoa1414799 original article:somatic mutations and clonal hematopoiesis in aplastic anemia by tetsuichi yoshizato et al n engl j med 2015; 373:35-47july 2, 2015doi: 10.1056/nejmoa1414799,

http://www.cancernetwork.com/myelodysplastic-syndromes/diagnosis-and-management-aplastic-anemia-and-myelodysplastic-syndrome diagnosis and management of aplastic anemia and myelodysplastic syndrome review article | september 03, 2002 | myelodysplastic syndromes by ronald l. paquette, md - see more at: http://www.cancernetwork.com/myelodysplastic-syndromes/diagnosis-and-management-aplastic-anemia-and-myelodysplastic-syndrome#sthash.cis7lxfx.dpuf

http://annals.org/article.aspx?articleid=715207 acquired aplastic anemia by neal s. young, md ann intern med. 2002;136(7):534-546. doi:10.7326/0003-4819-136-7-200204020-00011

http://icmr.nic.in/ijmr/2013/march/0307.pdf cytogenetic profile of aplastic anaemia in indian children by vineeta gupta, akash kumar, isha saini & ajit kumar saxena indian j med res 137, march 2013, pp 502-506

http://www.haematologica.org/content/93/4/518 epidemiology of aplastic anemia: a prospective multicenter study by eva montané, luisa ibáñez, xavier vidal, elena ballarín, ramon puig, nuria garcía, joan-ramon laporte haematologica april 2008 93: 518-523; doi:10.3324/haematol.12020

http://www.nature.com/bmt/journal/v48/n2/full/bmt2012224a.html review:bone marrow transplantation (2013) 48, 180–182; doi:10.1038/bmt.2012.224; published online 26 november 2012 treatment of aplastic anaemia in elderly patients aged >60 years by a tichelli and j c w marsh.

http://www.sciencedirect.com/science/article/pii/s2352003515000167 case report:aplastic anemia presenting as bleeding of gingiva: case report and dental considerations by arpita rai et al the saudi journal for dental research volume 7, issue 1, january 2016, pages 69–72 doi:10.1016/j.sjdr.2015.04.004

http://www.scielo.br/scielo.php?script=sci_arttext&pid=s0100-879x2000000500010 long-term outcome of 25 children and adolescents with severe aplastic anemia treated with antithymocyte globulin by c.r. de-medeiros et al.,http://dx.doi.org/10.1590/s0100-879x2000000500010 braz j med biol res, may 2000, volume 33(5) 553-558

http://cid.oxfordjournals.org/content/52/6/726.full decreased infection-related mortality and improved survival in severe aplastic anemia in the past two decades by jessica m. valdez et al., clin infect dis. (2011) 52 (6):726-735.doi: 10.1093/cid/ciq245

http://www.indianpediatrics.net/may2013/may-489-491.htm prevalence of parvovirus b 19 infection in children with aplastic anemia by vineeta gupta, isha saini and gopal nath* indian pediatr 2013;50: 489-491

http://cancerci.biomedcentral.com/articles/10.1186... primary research open access:reduced il-33 plasma levels in aplastic anemia by ming sun,hai-feng ma,ye-yun che and xin cuir cancer cell international201515:118 doi: 10.1186/s12935-015-0270-5

http://theoncologist.alphamedpress.org/content/1/6... aplastic anemia, pediatric aspects by blanche p. alter the oncologist december 1996 vol. 1 no. 6 361-366

 

Other articles:

http://www.petmd.com/cat/conditions/cardiovascular/c_ct_anemia_aplastic pet md anemia due to bone marrow failure (or toxicity) in cats

http://www.vcahospitals.com/main/pet-health-information/article/animal-health/ferrets-problems/980 vca hospitals aplastic anemia

 

Other helpful resources(support groups):

http://www.aamds.org/node/52 aplastic anemia and mds international foundation

http://www.aamac.ca/e/ aplastic anemia and myelidysplasia association of canada

http://www.theaat.org.uk/ aplastic anemia trust

https://www.justgiving.com/aplastic

 

Related videos:

https://www.youtube.com/watch?v=w8-jx1dtg0u johns hopkins medicine | aplastic anemia

https://www.youtube.com/watch?v=ve8rz19d_oo aplastic anemia

https://www.youtube.com/watch?v=2vjigro7yag aplastic anemia

https://www.youtube.com/watch?v=1yxjw5_sy5y aplastic anemia

https://www.youtube.com/watch?v=rlbzpg3envi aplastic anaemia : definition, aetiology, clinical features, diagnosis, treatment, prognosis (hd)

https://www.youtube.com/watch?v=2tsogz_k39a what is aplastic anemia causes, signs and symptoms for nursing students

https://www.youtube.com/watch?v=us1n0qknhzw what's new in aplastic anemia treatment?

 

Presentations/quiz/newspaper articles:

https://www.sciencedaily.com/releases/2016/02/160224133419.htm researchers fight aplastic anemia using a therapy designed to delay ageing,date:february 24, 2016 source:centro nacional de investigaciones oncologicas (cnio)

https://fhs.mcmaster.ca/medicine/hematology/docs/aplastic-anemia_one-of-the-states-of-bone-marrow-failure.pdfaplastic anemia,one of the states of bone marrow failure by marion s. sternbach, md,frcp(c), facp

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