Acute tubular necrosis (ATN) is a medical condition involving the death of tubular epithelial cells that form the renal tubules of thekidneys. ATN presents with acute kidney injury (AKI) and is one of the most common causes of AKI. Common causes of ATN include low blood pressure and use of nephrotoxic drugs. The presence of "muddy brown casts" of epithelial cells found in the urine during urinalysis is pathognomonic for ATN. Management relies on aggressive treatment of the factors that precipitated ATN (e.g. hydration and cessation of the offending drug). Because the tubular cells continually replace themselves, the overall prognosisfor ATN is quite good if the cause is corrected, and recovery is likely within 7 to 21 days.
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http://ajpheart.physiology.org/content/278/5/h1555 amelioration with vessel dilator of acute tubular necrosis and renal failure established for 2 days by linda c. clark, hanan farghaly, sabiha r. saba, david l. vesely american journal of physiology - heart and circulatory physiology published 1 may 2000 vol. 278 no. 5, h1555-h1564 doi: