acetaminophen-toxicity
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Acetaminophen Toxicity

Acetaminophen Toxicity

Last Reviewed : 12/23/2020
Acetaminophen Toxicity

Paracetamol toxicity is caused by excessive use or overdose of the analgesic drug paracetamol (called acetaminophen in North America). Mainly causing liver injury, paracetamol toxicity is one of the most common causes of poisoning worldwide.

The signs and symptoms of paracetamol toxicity begins within hours of overdose, and consists of nausea, vomiting, pallor, and sweating. Treatment is aimed at removing the paracetamol from the body and replacing glutathione. Activated charcoal can be used to decrease absorption of paracetamol if the patient presents for treatment soon after the overdose; the antidote acetylcysteine acts as a precursor for glutathione, helping the body regenerate enough to prevent damage to the liver.

 

We researched this topic for you and found the following best online resources. They are categorized into basic, advanced, and research level based on the extent of information you need. You will be taken to the respective websites by pressing on the links below.

 

 

Basic Information:

http://emedicine.medscape.com/article/820200-overview. Medscape. Acetaminophen Toxicity

http://www.msdmanuals.com/professional/injuries-poisoning/poisoning/acetaminophen-poisoning. MSD manuals. Acetaminophen poisoning By Gerald F. O’Malley, DO, Rika O’Malley, MD.

https://www.nlm.nih.gov/medlineplus/ency/article/002598.htm. Medline Plus. Acetaminophen overdose.

http://www.rch.org.au/clinicalguide/guideline_index/Paracetamol_Poisoning/. The Royal Childrens Hospital Melbourne. Paracetamol Poisoning.

https://www.acep.org/Clinical---Practice-Management/Focus-On--Acetaminophen-Toxicity-and-Treatment/. AECP (American College of Emergency Physicians) . Acetaminophen Toxicity and Treatment

http://patient.info/doctor/paracetamol-poisoning. Patient. Paracetamol poisoning .

https://www.mcgill.ca/criticalcare/teaching/files/toxicology/acetaminophen. McGill Critical Care Medicine. Acetaminophen Toxicity

http://www.ahcmedia.com/articles/129616-acetaminophen-toxicity. AHC Media. Acetaminophen Toxicity .

http://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307266/all/Acetaminophen_Poisoning. Emergency Central. Acetaminophen poisoning .

http://www.wikiwand.com/en/Paracetamol_toxicity. Wikiwand. Acetaminophen Toxicity .

 

Advanced Information:

http://www.nejm.org/doi/full/10.1056/NEJM199710163371602#t=abstract. NEJM (New England Journal of Medicine). Acetaminophen Toxicity in an Urban County Hospital

http://www.jbc.org/content/274/15/10349.full#content-block. JBC (Journal of Biological Chemistry). Acetaminophen Toxicity . OPPOSITE EFFECTS OF TWO FORMS OF GLUTATHIONE PEROXIDASE by Oleg Mirochnitchenko, Miriam Weisbrot-Lefkowitz, Kenneth Reuhl, Laishun Chen?, Chung Yang? and Masayori Inouye.

 

Research:

https://www.jci.org/articles/view/59755. American Society of Clinical Investigation. The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation by Mitchell R. McGill,1 Matthew R. Sharpe,2 C. David Williams,1 Mohammad Taha,2 Steven C. Curry,3 and Hartmut Jaeschke1.

http://www.worldwidejournals.com/ijar/file.php?val=December_2013_1385987027_62b5c_144.pdf. Worldwide Journals. Acute Paracetamol Toxicity - A Case Report by Dr. Sameer Kulkarni.

 

Related Topics:

http://pediatrics.aappublications.org/content/108/4/1020. AAP gateway (American Academy of Pediatrics). Acetaminophen Toxicity in Children.

http://dmd.aspetjournals.org/content/31/12/1499.full. ASPET Journals (American Society for Pharmacology and Experimental Therapeutics ). ACETAMINOPHEN-INDUCED HEPATOTOXICITY by Laura P. James, Philip R. Mayeux and Jack A. Hinson

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131010. PLOS One. Comparison of Bile Acids and Acetaminophen Protein Adducts in Children and Adolescents with Acetaminophen Toxicity by Laura James etal.

http://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-11-125. BIOmed Central. Ringer's lactate improves liver recovery in a murine model of acetaminophen toxicity by Runkuan Yang etal.

 

Other Articles:

https://www.mja.com.au/journal/2008/188/5/guidelines-management-paracetamol-poisoning-australia-and-new-zealand-explanation. MJA (Medical Journal of Australia). Guidelines for the management of paracetamol poisoning in Australia and New Zealand — explanation and elaboration

http://qjmed.oxfordjournals.org/content/95/9/609. Oxford University Press. Paracetamol toxicity: epidemiology, prevention and costs to the health-care system by C.L. SHEEN, J.F. DILLON, D.N. BATEMAN, K.J. SIMPSON, T.M. MACDONALD.

http://www.upi.com/Health_News/2015/08/17/Researchers-Acetaminophen-toxic-at-lower-levels-than-thought/8721439825741/. UPI (United Press International). Researchers: Acetaminophen toxic at lower levels than thought.

http://www.prnewswire.com/news-releases/research-highlights-risk-for-acetaminophen-toxicity-from-use-of-over-the-counter-and-prescription-pain-medications-253931861.html. PR news wire. Research Highlights Risk for Acetaminophen Toxicity from Use of Over the Counter and Prescription Pain Medications

http://rnjournal.com/journal-of-nursing/a-mouthful-of-death-acetaminophen-overdose. RN Journal. A Mouthful of Death: Acetaminophen Overdose

 

Other Helpful Resources:

http://www.biochemj.org/content/399/3/455. Biochemical Journal. Mice deficient in Cu, Zn-superoxide dismutase are resistant to acetaminophen toxicity.

 

 

Presentations

https://www.aacc.org/~/media/files/meetings-and-events/resources-from-past-events/conferences/2013/professional-practice/april-28/gc_toxicology_case_studies_apr_28_2013.pdf?la=en. Toxicology Case Studies Acetaminophen and Liver Function by Alison Woodworth, PhD

http://www.slideshare.net/alanisaad/acetaminophen-poisoning. slideshare. Acetaminophen poisoning in children.

http://www.powershow.com/view/801d3-ZWU1M/Acetaminophen_Toxicity_powerpoint_ppt_presentation. Powershow. Acetaminophen Toxicity .

 

 

 

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